A5008794522- SARS-CoV-2 and COVID-19 Research
- Ship Hydrodynamics and Maneuverability
- COVID-19 Clinical Research Studies
- SARS-CoV-2 detection and testing
- Fluid Dynamics Simulations and Interactions
- Maritime Transport Emissions and Efficiency
- Advanced Multi-Objective Optimization Algorithms
- Influenza Virus Research Studies
- Metaheuristic Optimization Algorithms Research
- Chronic Lymphocytic Leukemia Research
- Scientific Research and Discoveries
- Viral gastroenteritis research and epidemiology
- Ethics in Clinical Research
- Bacillus and Francisella bacterial research
- Usability and User Interface Design
- Innovative Human-Technology Interaction
- vaccines and immunoinformatics approaches
- Cardiac Fibrosis and Remodeling
- Cholesterol and Lipid Metabolism
- Congenital Heart Disease Studies
- Antifungal resistance and susceptibility
- Granular flow and fluidized beds
- Viral Infections and Outbreaks Research
- Fluid Dynamics and Vibration Analysis
- Fluid dynamics and aerodynamics studies
Fudan University
2018-2024
Peking University
2010-2023
Peking University People's Hospital
2019-2023
George Mason University
2011-2015
Peking University Third Hospital
2010
University of Shanghai for Science and Technology
2009
Abstract The COVID-19 pandemic poses a global threat to public health and economy. continuously emerging SARS-CoV-2 variants present major challenge the development of antiviral agents vaccines. In this study, we identified that EK1 cholesterol-coupled derivative EK1, EK1C4, as pan-CoV fusion inhibitors, exhibit potent activity against infection in both lung- intestine-derived cell lines (Calu-3 Caco2, respectively). They are also effective pseudotyped B.1.1.7 (Alpha) B.1.1.248 (Gamma) well...
Continuous emergence of the Omicron variant, along with its subvariants, has caused an increasing number infections, reinfections, and vaccine-breakthrough seriously threatening human health. Recently, several new such as BA.5, BA.2.75, BA.4.6, BF.7, bearing distinct mutation profiles in their spike (S) proteins, have significantly increased capacity to evade vaccine-induced immunity shown enhanced infectivity transmissibility, quickly becoming dominant sublineages. In this study, we found S...
Abstract Numerous emerging severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2) Omicron subvariants have shown significant immune evasion capacity and caused a large number of infections, as well vaccine‐breakthrough especially in elderly populations. Recently emerged XBB was derived from the BA.2 lineage, but bears distinct mutant profile its spike (S) protein. In this study, we found that S protein drove more efficient membrane‐fusion kinetics on human lung‐derived cells (Calu‐3)....
The artificial bee colony (ABC) algorithm is a relatively new swarm intelligence-based optimization algorithm. Its simplicity of implementation, few parameter settings and promising capability make it widely used in different fields. However, has problems slow convergence due to its solution search equation. Here, equation based on combination the elite pool block perturbation scheme proposed improve performance In addition, two equations are by employed bees onlooker balance exploration...
Our previous studies have shown that cholesterol-conjugated, peptide-based pan-coronavirus (CoV) fusion inhibitors can potently inhibit human CoV infection. However, only palmitic acid (C16)-based lipopeptide drugs been tested clinically, suggesting the development of C16-based is feasible. Here, we designed and synthesized a C16-modified pan-CoV inhibitor, EK1-C16, found it inhibited infection by SARS-CoV-2 its variants concern (VOCs), including Omicron, other CoVs bat SARS-related...
The COVID-19 pandemic caused by SARS-CoV-2 infection poses a serious threat to global public health and the economy. enzymatic product of cholesterol 25-hydroxylase (CH25H), 25-Hydroxycholesterol (25-HC), was reported have potent anti-SARS-CoV-2 activity. Here, we found that combination 25-HC with EK1 peptide, pan-coronavirus (CoV) fusion inhibitor, showed synergistic antiviral We then used method modification design synthesize series 25-HC-modified peptides peptide (EK1P4HC) highly...
Along with the long pandemic of COVID-19 caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has come dilemma emerging viral variants concern (VOC), particularly Omicron and its subvariants, able to deftly escape immune surveillance otherwise protective effect current vaccines antibody drugs. We previously identified a peptide-based pan-CoV fusion inhibitor, termed as EK1, bind HR1 region in spike (S) protein S2 subunit. This effectively blocked formation six-helix bundle...
A new methodology for hydrodynamic optimization of a TriSWACH is developed, which considers the shape center hull only and its optimal results are not influenced by position configuration side hulls. In order to accelerate process optimization, practical multi-objective tool has been further developed integrating surrogate model approximate objective functions constraints. The proposed method applied optimize form with nine possible configurations reduced drag. considerable drag reduction...
A novel wedge-shaped hull form is optimized for reduced drag using a further developed practical hydrodynamic optimization tool. The features sharp entrance angle, rectilinear sides, bottom edges, triangular waterplane and linear aftward taper from deep bow to shallow transom. involves two modifications of the form, one smooth out edge with rounded corner other generate bulbous bow. In order perform hull, Non-Uniform Rational BSpline (NURBS)-based surface modification tool, NURBS mesh...
A fast and reliable liquid chromatography coupled with atmospheric pressure chemical ionization tandem mass spectrometry (LC-APCI-MS/MS) method was developed validated for the quantification of voriconazole in human plasma. The proposed a linear range 50-10,000 ng/ml, total run time 1.5 min. This successfully used to support routine therapeutic drug monitoring voriconazole.
Simple analytical relations that can readily be applied to verify a critical aspect of numerical predictions fully nonlinear free-surface flows around ship hulls steadily advancing in calm water are given. The do not involve the flow field equations; is, they only based on boundary conditions at hull surface and free surface. These have predominant influence hulls. exact for inviscid flows, methods solve either Laplace equation (potential-flow methods) or Euler equations (CFD Euler-flow...
Objective To analyze the main factors affecting compliance of subjects in anti-hypertension drug clinical trials and explore methods management. Methods 18 Peking University People's Hospital from May 2007 to Dec. 2013 were summarized. The causes drop-out analyzed. Results Among 614 cases, there 44 drop-outs.13 drop-outs appeared 6 international multi-center trials.The rate cases due personal reasons was 71% factor influencing drop-out. Drug environment 18% 11%,...