A5036260030- Zebrafish Biomedical Research Applications
- RNA Research and Splicing
- Single-cell and spatial transcriptomics
- Congenital heart defects research
- MicroRNA in disease regulation
Nantong University
2021-2022
The pMN domain is a restricted in the ventral spinal cord, defined by expression of olig2 gene. Though it known that progenitor cells can sequentially generate motor neurons and oligodendrocytes, lineages these progenitors are controversial how their progeny generated not well understood. Using single-cell RNA sequencing, here, we identified previously unknown heterogeneity among with distinct fates molecular signatures zebrafish. Notably, characterized two neuron using bioinformatic...
Abstract The pMN domain is a restricted in the ventral spinal cords, defined by expression of olig2 gene. fate determination progenitors highly temporally and spatially regulated, with motor neurons oligodendrocyte progenitor cells (OPCs) developing sequentially. Insight into heterogeneity molecular programs currently lacking. With zebrafish model, we identified multiple states neural using single-cell sequencing: proliferating progenitors, common for both OPCs, precursors either or OPCs. We...