A5056424577- Animal Virus Infections Studies
- SARS-CoV-2 and COVID-19 Research
- COVID-19 Clinical Research Studies
- RNA regulation and disease
- RNA Interference and Gene Delivery
- Viral gastroenteritis research and epidemiology
- interferon and immune responses
- RNA and protein synthesis mechanisms
Houston Methodist
2024
Mahidol University
2021-2022
Updated and revised versions of COVID-19 vaccines are vital due to genetic variations the SARS-CoV-2 spike antigen. Furthermore, that safe, cost-effective, logistic-friendly critically needed for global equity, especially middle- low-income countries. Recombinant protein-based subunit against have been reported using receptor-binding domain (RBD) prefusion trimers (S-2P). Recently, a new version trimers, named HexaPro, has shown possess two RBD in “up” conformation, its physical property, as...
Abstract Updated and revised versions of COVID-19 vaccines are vital due to genetic variations the SARS-CoV-2 spike antigen. Furthermore, that safe, cost-effective, logistically friendly critically needed for global equity, especially middle low income countries. Recombinant protein-based subunit against have been reported with use receptor binding domain (RBD) prefusion trimers (S-2P). Recently, a new version trimers, so called “HexaPro”, has shown its physical property possess two RBD in...
Abstract The COVID-19 mRNA vaccines demonstrated the power of medicines. Despite advancements in sequence design, evidence regarding preferential use synonymous codons on cellular stress and innate immune responses is lacking. To this end, we developed a proprietary codon optimality matrix to re-engineer coding sequences three luciferase reporters. We demonstrate that optimal mRNAs elicited dramatic increases activities compared non-optimal sequences. Notably, transfecting an RNA affects...
Abstract Next-generation COVID-19 vaccines are critical due to the ongoing evolution of SARS-CoV-2 virus and waning duration neutralizing antibody response against current vaccines. The mRNA mRNA-1273 BNT162b2 were developed using linear transcripts encoding prefusion-stabilized trimers (S-2P) wildtype spike, which have shown a reduced activity variants concern B.1.617.2 B.1.1.529. Recently, new version spike trimer, termed VFLIP has been suggested possess native-like glycosylation, greater...