A5023273885- Bioinformatics and Genomic Networks
- Genetic Associations and Epidemiology
- SARS-CoV-2 and COVID-19 Research
- COVID-19 epidemiological studies
- Advanced Proteomics Techniques and Applications
- Health, Environment, Cognitive Aging
- Atrial Fibrillation Management and Outcomes
- MicroRNA in disease regulation
- Trace Elements in Health
- Physiological and biochemical adaptations
- Viral Infections and Outbreaks Research
- Gene expression and cancer classification
- Genomics, phytochemicals, and oxidative stress
- Congenital heart defects research
- Iron Metabolism and Disorders
- Metabolomics and Mass Spectrometry Studies
- COVID-19 Clinical Research Studies
- Cancer Cells and Metastasis
- TGF-β signaling in diseases
- Cancer-related molecular mechanisms research
- RNA modifications and cancer
- Scottish History and National Identity
- COVID-19 Pandemic Impacts
- Cardiovascular Disease and Adiposity
- Drug Transport and Resistance Mechanisms
Norwegian University of Science and Technology
2019-2024
In breast cancer, activation of bone morphogenetic protein (BMP) signaling and elevated levels BMP-antagonists have been linked to tumor progression metastasis. However, the simultaneous upregulation BMPs their antagonist, fact that both promote aggressiveness seems contradictory is not fully understood.We analyzed transcriptomes metastatic 66cl4 non-metastatic 67NR cell lines 4T1 mouse mammary model search for factors CRISPR/Cas9 gene editing was used mechanistic studies in same lines....
Many breast cancer patients are diagnosed with small, well-differentiated, hormone receptor-positive tumors. Risk of relapse is not easily identified in these patients, resulting overtreatment. To identify metastasis-related gene expression patterns, we compared the transcriptomes non-metastatic 67NR and metastatic 66cl4 cell lines from murine 4T1 mammary tumor model. The transcription factor nuclear factor, erythroid 2-like 2 (NRF2, encoded by NFE2L2) was constitutively activated cells...
High secretion of the metabolites citrate and spermine is a unique hallmark for normal prostate epithelial cells, reduced in aggressive cancer. However, identity genes controlling this biological process mostly unknown. In study, we have created gene signature 150 connected to prostate. We computationally integrated metabolic measurements with multiple transcriptomics datasets from public domain, including 3826 tissue samples The accuracy validated by its enrichment compartments. highlights...
Abstract Background While invasive social distancing measures have proven efficient to control the spread of pandemics failing wide-scale deployment vaccines, they carry vast societal costs. The development a diagnostic methodology for identifying COVID-19 infection through simple testing was reality only few weeks after novel virus officially announced. Thus, we were interested in exploring ability regular non-symptomatic people reduce cases and thereby offer non-pharmaceutical tool...
ABSTRACT Genetic research into Atrial Fibrillation (AF) and Myocardial Infarction (MI) has predominantly concentrated on contrasting afflicted individuals with their healthy counterparts. However, this approach lacks granularity, overlooking the subtleties within patient populations. In study, we explore distinction between AF MI patients experiencing only single events to those recurrent events. Integrating hospital records, questionnaire data, clinical measurements, genetic data from more...
Genetic research into atrial fibrillation (AF) and myocardial infarction (MI) has predominantly focused on comparing afflicted individuals with their healthy counterparts. However, this approach lacks granularity, thus overlooking subtleties within patient populations. In study, we explore the distinction between AF MI patients who experience only a single disease event those experiencing recurrent events. Integrating hospital records, questionnaire data, clinical measurements, genetic data...
Disease networks offer a potential road map of connections between diseases. Several studies have created disease where diseases are connected either based on shared genes or Single Nucleotide Polymorphism (SNP) associations. However, it is still unclear to which degree SNP-based empirical, co-observed within different, general, adult study population spanning over long time period. We phenome-wide association network (PheNet) from large using the UK biobank studies. Importantly,...
Using abundance measurements of 1,490 proteins from four separate populations three-spined sticklebacks, we implemented a system-level approach to correlate proteome dynamics with environmental salinity and temperature the fish's population morphotype. We identified robust accurate fingerprints that classify salinity, temperature, morphotype, sample origin, observing specific functions are enriched in these fingerprints. Highly apparent represented all include ion transport, proteostasis,...
ABSTRACT Using abundance measurements of 1,490 proteins from four separate populations three-spined sticklebacks, we implemented a system-level approach to correlate proteome dynamics with environmental salinity and temperature the fish’s population morphotype. We identified sets robust accurate fingerprints that predict salinity, temperature, morphotype sample origin, observing specific functions are enriched in these fingerprints. Highly apparent represented all include ion transport,...
While invasive social distancing measures have proven efficient to control the spread of pandemics in absence a vaccine, they carry vast societal costs. Guided by finding that large households function as hubs for propagation COVID-19, we developed data-driven individual-based epidemiological network-model assess intervention efficiency targeted testing larger households. For an outbreak with reproductive number R = 1.5, find weekly just 15% largest is capable forcing below unity. case 1.2,...
Abstract Background Disease networks offer a potential road map of connections between diseases. Several studies have created disease where diseases are connected either based on shared genes or Single Nucleotide Polymorphisms (SNP) associations. However, it is still unclear to which degree SNP-based empirical co-observed within different, general, adult study population spanning over long time period. Methods We create network (PheNet) from large using the UK biobank phenome-wide...
Abstract Background: Disease networks offer a potential road map of connections between diseases. Several studies have created disease where diseases are connected either based on shared genes or Single Nucleotide Polymorphism (SNP) associations. However, it is still unclear to which degree SNP-based empirical co-observed within different, general, adult study population spanning over long time period. Methods: We create network (PheNet) from large using the UK biobank phenome-wide...
Abstract Background Secretion of the metabolites citrate and spermine into prostate lumen is a unique hallmark for normal epithelial cells. However, identity genes controlling secretion remains mostly unknown despite their obvious relevance progression to aggressive cancer. Materials & Methods In this study, we have correlated simultaneous measurement citrate/spermine transcriptomics data. We refined these gene correlations in 12 cancer cohorts containing 2915 tissue samples create novel...