A5074969026- Polyamine Metabolism and Applications
- Enzyme Structure and Function
- Polysaccharides and Plant Cell Walls
- Plant Stress Responses and Tolerance
- Trypanosoma species research and implications
- Malaria Research and Control
- Biochemical and Molecular Research
- Plant-Microbe Interactions and Immunity
- Plant responses to water stress
- Plant tissue culture and regeneration
- Cholinesterase and Neurodegenerative Diseases
- Genetics, Aging, and Longevity in Model Organisms
- Biochemical and biochemical processes
- Synthesis and Catalytic Reactions
- Metabolism, Diabetes, and Cancer
- Plant pathogens and resistance mechanisms
- Drug-Induced Hepatotoxicity and Protection
- Fungal and yeast genetics research
- Steroid Chemistry and Biochemistry
- Biotechnology and Related Fields
- Viral gastroenteritis research and epidemiology
- Analytical Chemistry and Chromatography
- Plant nutrient uptake and metabolism
- Enzyme function and inhibition
- Bacterial Genetics and Biotechnology
University of Pretoria
2011-2024
Council for Scientific and Industrial Research
2008-2011
Stellenbosch University
2003-2011
Heinrich Heine University Düsseldorf
2002
Goethe University Frankfurt
1995-1996
University of Oxford
1965
The stilbene resveratrol is a stress metabolite produced by Vitis vinifera grapevines during fungal infection, wounding or UV radiation. Resveratrol synthesised particularly in the skins of grape berries and only trace amounts are present fruit flesh. Red wine contains much higher concentration than white wine, due to skin contact fermentation. Apart from its antifungal characteristics, has also been shown have cancer chemopreventive activity reduce risk coronary heart disease. It acts as an...
local contexts in each of the respective countries.
Sorghum is particularly drought tolerant compared with other cereal crops and favoured for subsistence farming in water scarce regions of the world. This study was conducted to identify South African sorghum landraces superior tolerance a drought-tolerant breeding line (P898012). Seedlings 14 landrace accessions were initially screened by assessing percentage leaf content (LWC) during progressive deficit. Four (designated LR5, LR6, LR35, LR36) recorded higher LWC than P898012. These...
Abstract Background Anti-malarial drug resistance threatens to undermine efforts eliminate this deadly disease. The resulting omnipresent requirement for drugs with novel modes of action prompted a national consortium initiative discover new anti-plasmodial agents from South African medicinal plants. One the plants selected investigation was Dicoma anomala subsp. gerrardii , based on its ethnomedicinal profile. Methods Standard phytochemical analysis techniques, including solvent-solvent...
We have investigated the role and kinetic properties of Hxt5 glucose transporter Saccharomyces cerevisiae. The HXT5 gene was not expressed during growth yeast cells in rich medium with or raffinose. However, it became strongly induced nitrogen carbon starvation. constructed strains constitutively expressing only Hxt5, Hxt1 (low affinity) Hxt7 (high affinity), but no other transporters. Aerobic fed-batch cultures at quasi steady-state conditions, aerobic anaerobic chemostat conditions these...
Abstract Background Polygalacturonase-inhibiting proteins (PGIPs) directly limit the effective ingress of fungal pathogens by inhibiting cell wall-degrading endopolygalacturonases (ePGs). Transgenic tobacco plants over-expressing grapevine ( Vitis vinifera ) Vvpgip1 have previously been shown to be resistant Botrytis infection. In this study we characterized two these PGIP lines with known resistance phenotypes gene expression and hormone profiling in absence pathogen Results Global was...
Sorghum is indigenous to Africa and a remarkably drought tolerant cereal crop. In this study, the genetic response mechanisms involved in sorghum's tolerance progressive water deficit re-watering were investigated South African landrace (designated LR6), using cDNA microarrays comprising 35,899 transcript probes. Significant differential expression of 902 transcripts, including 128 transcripts with currently unknown functions, was altered stress re-watering. The modulated sorghum genes had...
Abstract Background Plasmodium falciparum , the causative agent of severe human malaria, has evolved to become resistant previously successful antimalarial chemotherapies, most notably chloroquine and antifolates. The prevalence strains necessitated discovery development new chemical entities with novel modes-of-action. Although much effort been invested in creation analogues based on existing drugs screening natural compound libraries, a crucial shortcoming current Plasmodial drug efforts...
Gene regulation of the malaria parasite Plasmodium falciparum has proven to be complex with evidence supporting both transcriptional [1,2] and post-transcriptional level control [3,4]. Transcriptional profiling environmentally perturbed parasites can reveal functionally related genes common regulatory mechanisms that are responsive external stimuli [2]. By interrogating microarray data derived from P. populations treated several drug classes, a subset four potentially involved parasite's...