A5025091141- Spine and Intervertebral Disc Pathology
- Musculoskeletal pain and rehabilitation
- Bone health and osteoporosis research
- Spondyloarthritis Studies and Treatments
- Bone health and treatments
- Stroke Rehabilitation and Recovery
Oulu University Hospital
2014-2021
University of Oulu
2014-2021
Modic changes (MC) are associated with low back pain (LBP), but effective treatments lacking. The aim of this randomized, placebo-controlled, double-blinded trial was to evaluate the efficacy zoledronic acid (ZA) for chronic LBP among patients MC in magnetic resonance imaging (MRI). Inclusion criteria were lasting ≥3 months, an intensity ≥6 on a 10-cm VAS or Oswestry Disability Index (ODI) ≥30%, and MRI. Patients randomized into single intravenous infusion ZA 5 mg (n = 20), placebo 20)...
Modic changes (MC) are associated with low back pain (LBP). In this study, we compared in size and type of MC, after a single intravenous infusion 5 mg zoledronic acid (ZA) or placebo, among chronic LBP patients MC on magnetic resonance imaging (MRI), evaluated whether the MRI correlate symptoms. All (N = 19 ZA, 20 placebo) had at baseline (0.23–1.5 T) one year (1.5-3 T). We level, volume all MC. The were classified into M1 (M1 (100%)), predominating (M1/2 (65:35%)) M2 (35:65%)), (M2...
The aim of the current study was to compare changes in serum biomarkers, including inflammatory mediators, signaling molecules, growth factors and markers bone turnover after a single intravenous infusion 5 mg zoledronic acid (ZA, long-acting bisphosphonate; n = 20) or placebo (n among patients with Modic (MC) chronic low back pain randomized controlled design. MCs were classified into M1, predominating M2, M2. We measured concentrations 39 biomarkers at baseline, one month year treatment....
To compare the effectiveness of group rehabilitation and individually dosed in treating chronic low back pain.Institutional intervention 2 nonrandomized groups with a 6-month post-intervention follow-up.Persons pain: 64 group-rehabilitated 66 rehabilitated.The period for all subjects was 21 days. Those being group-rehabilitated, about 10 patients per group, had common programme including 3-5 exercise day, discussions lectures neck school. Local physical therapy given if neeeded. The...