A5074101823- Child and Adolescent Psychosocial and Emotional Development
- Birth, Development, and Health
- Stress Responses and Cortisol
- Mental Health Research Topics
- Identity, Memory, and Therapy
- Hypothalamic control of reproductive hormones
- Anxiety, Depression, Psychometrics, Treatment, Cognitive Processes
- Early Childhood Education and Development
- Health, Environment, Cognitive Aging
- Neuroendocrine regulation and behavior
- Functional Brain Connectivity Studies
- Child Abuse and Trauma
- Health disparities and outcomes
- Genetics, Aging, and Longevity in Model Organisms
- Epigenetics and DNA Methylation
- Bipolar Disorder and Treatment
- Ethics in medical practice
- Nutritional Studies and Diet
- Educational and Psychological Assessments
- Intergenerational Family Dynamics and Caregiving
- Obesity, Physical Activity, Diet
- Maternal Mental Health During Pregnancy and Postpartum
- Personality Traits and Psychology
- Genetic Associations and Epidemiology
- Empathy and Medical Education
University of California, San Francisco
2021-2025
Langley Porter Psychiatric Hospital and Clinics
2024
Angeles University Foundation
2022
University of Illinois Urbana-Champaign
2018-2020
University of Illinois Chicago
2017-2019
Temple University
2012-2016
Temple College
2015-2016
University of Washington
2016
Columbia University
2016
Harvard University
2016
Aging | doi:10.18632/aging.204434. Ake T. Lu, Alexandra M. Binder, Joshua Zhang, Qi Yan, Alex P. Reiner, Simon R. Cox, Janie Corley, Sarah E. Harris, Pei-Lun Kuo, Ann Z. Moore, Stefania Bandinelli, James D. Stewart, Cuicui Wang, Elissa J. Hamlat, S. Epel, Joel Schwartz, Eric A. Whitsel, Adolfo Correa, Luigi Ferrucci, Riccardo Marioni, Steve Horvath
Extensive comorbidity between depression and anxiety has driven research to identify unique shared risk factors. This study prospectively examined the specificity of three interpersonal stressors (emotional abuse, emotional neglect, relationally oriented peer victimization) as predictors depressive versus symptoms in a racially diverse community sample adolescents. We expanded on past by examining hopelessness mediator relationships these symptoms. Participants included 225 adolescents (55%...
Evidence suggests that early pubertal timing may operate as a transdiagnostic risk factor (i.e., shared across syndromes of psychopathology) for both genders. The current study examined associations between and dimensional psychopathology, structured different levels three organizational models: 1) DSM-based syndrome model, 2) traditional model internalizing externalizing factors, 3) bifactor (p-factor) which includes general psychopathology well internalizing- externalizing- specific...
Abstract Background Given associations linking early life adversity, pubertal timing, and biological aging, we examined the direct indirect effects of trauma on adult aging (via age menarche). Methods Participants were premenopausal women ( N = 183). Path models evaluated whether predicted timing thereby, epigenetic acceleration (indexed via four clocks: Horvath DNAm Age, Hannum PhenoAge, GrimAge). Secondary analyses explored type (abuse neglect) chronic stress status (caregiver child with...
For more than 20 years, researchers have attempted to identify diagnostic and prognostic biomarkers for psychiatric disorders including schizophrenia, major (unipolar) depression, bipolar disorder.Advocates of this research contend that identifying such will aid in the diagnosis these disorders, as well possible development effective medications treat them.Currently, there are no tests available.This is largely due multi-factorial nature disorders.Biomarker testing individuals also...
Adolescence marks the emergence of sex differences in internalizing symptoms and disorders, with girls at increased risk for depression anxiety during pubertal transition. However, mechanisms through which puberty confers psychopathology girls, but not boys, remain unclear. We examined two indicators (pubertal status timing) as predictors development emotion regulation styles (rumination emotional clarity) depressive disorders a three-wave study 314 adolescents. Path analyses indicated that...
Background Major depressive disorder often is characterized by a lack of cognitive and emotional flexibility, resulting in an impaired ability to adapt situational demands. Adolescence important period risk for the first onset depression, yet relatively little known about whether aspects inflexibility, such as rumination deficits attentional shifting, could confer development during this time. Method In present study, sample 285 never-depressed adolescents completed self-report behavioral...
Importance Nutritive compounds play critical roles in DNA replication, maintenance, and repair, also serve as antioxidant anti-inflammatory agents. Sufficient dietary intakes support genomic stability preserve health. Objective To investigate the associations of patterns, including essential nutrients added sugar, diet quality scores established new nutrient indices with epigenetic age a diverse cohort Black White women at midlife. Design, Setting, Participants This cross-sectional study...
Abstract Background The current study examined if early adversity was associated with accelerated biological aging, and effects were mediated by the timing of puberty. Methods In mid-life, 187 Black 198 White ( M age = 39.4, s.d. 1.2) women reported on abuse at first menstruation (menarche). Women provided saliva blood to assess epigenetic telomere length, C-reactive protein. Using structural equation modeling, we created a latent variable aging using protein as indicators, indicators...
ABSTRACT The “geroscience hypothesis” posits that slowing the physiological processes of aging would lead to delayed disease onset and longer healthspan lifespan. This shift from a focus on solely treating existing process is toward prevention, including risk factors found in social environment. Although geroscience traditionally has focused molecular cellular drivers biological aging, more fundamental causes may be exposome—the complex array human environmental exposures shape health...
Although early adversity is strongly related to lifelong health disparities, it unclear how might confer risk across generations. To investigate, we tested the hypothesis that mothers' childhood was associated with their epigenetic aging and of children examined whether associations differed for Black White mothers. Dyads (N = 215) mothers (52% White, 48% Black, Mage 39.2, SD 1.1) 215, 55% female, 8.3, 4.0, range 2-17) provided saliva samples assay Horvath clock pace calculated from...
Deep brain stimulation (DBS) is well suited to target disorders with network dysregulation, as the case in many neuropsychiatric diseases. While DBS a well-established therapy for Parkinson’s disease, essential tremor, dystonia, and medically refractory epilepsy, it actively being studied clinical trials including treatment-refractory major depressive disorder (MDD). Due nature of symptomology participant characteristics, special care must be taken design implementation testing disorders. In...
This study prospectively examined pubertal timing and peer victimization as interactive predictors of depressive symptoms in a racially diverse community sample adolescents. We also expanded on past research by assessing body esteem mechanism which confer risk for depression. In all, 218 adolescents (53.4% female, 49.3% African American, 50.7% Caucasian) completed both baseline assessment follow-up approximately 8 months later. Early maturing Caucasian girls late American experienced the...
Background Recurrent depressive episodes during adolescence result in significant impairment and increased risk for subsequent adverse outcomes throughout the life span. Evidence suggests that early pubertal timing predicts onset of (particularly girls); however, it is not known if prospectively recurrent youth. Methods At baseline, 603 youth (56% female, at baseline: M age = 12.09, SD 2.35) reported on their development. Youth parents completed a semistructured diagnostic interview to...
ABSTRACT Objective Although exposure to abuse in early life predicts earlier pubertal timing, especially for girls, it is unclear if this association generalizes nonabuse stressors. In addition, the impact of race on stress-maturation remains unknown. To address these issues, we examined whether moderates effects adversity timing and tempo using a longitudinal study design. Methods cohort 9- 10-year-old Black White (areolar pubic hair) maturation was assessed annually 7 years. adulthood, 368...
Importance Low childhood socioeconomic status (SES) is a social hallmark of aging that contributes to adult health disparities and earlier morbidity mortality. Childhood perceptions stress are associated with child outcomes may contribute premature biological into adulthood. Objective To describe the association SES perceived midlife insulin resistance epigenetic age explore whether late adolescent adiposity mediates observed associations. Design, Setting, Participants The longitudinal...
Subjective social status (SSS), an individual's assessment of their own in relation to others, is associated with health and mortality independently objective SES; however, no studies have tested whether SSS influences epigenetic aging. The current study examines if age acceleration both Black White women, SES measured during childhood adulthood. For 9- 10-year-old girls, parental education annual household income was obtained. At ages 39–42, 361 participants (175 Black, 186 White) reported...