A5087529598- Multicomponent Synthesis of Heterocycles
- Synthesis and biological activity
- Synthesis of Tetrazole Derivatives
- Synthesis and Characterization of Heterocyclic Compounds
- Microwave-Assisted Synthesis and Applications
- Computational Drug Discovery Methods
- Catalytic Cross-Coupling Reactions
- Synthesis and Reactions of Organic Compounds
- Catalytic C–H Functionalization Methods
- Ethnobotanical and Medicinal Plants Studies
- Catalytic Alkyne Reactions
- Crystallization and Solubility Studies
- Synthesis of Organic Compounds
- Cassava research and cyanide
- Protein Structure and Dynamics
- Synthesis and Biological Evaluation
- Nanomaterials for catalytic reactions
- Magnetic and Electromagnetic Effects
- X-ray Diffraction in Crystallography
- Oxidative Organic Chemistry Reactions
- Heat shock proteins research
- Natural Antidiabetic Agents Studies
- Chemical Synthesis and Reactions
- Synthesis of Indole Derivatives
- Organoboron and organosilicon chemistry
University of Shahrood
2016-2022
Shahid Beheshti University
2007
Multi-component reactions of aldehydes, amines, and alkynes in magnetized water as a green-promoting medium.
Inhibition of heat shock protein 90 (Hsp90) is known to be a significantly effective strategy in cancer therapy. Here, pyrazolopyranopyrimidine derivatives were characterized as new Hsp90 inhibitors. The molecules' key structure (ZINC02819805) was determined by utilizing pharmacophore model virtual screening workflow. Structural optimization then carried out on compound ZINC02819805, designed and six chosen synthesized. inhibition ATPase activity synthesized compounds revealed that para...
Background: The design of biologically-active compounds is a challenging viewpoint in medicinal chemistry, and pyranopyrazoles pyranopyrimidine play crucial role as biologicallyactive molecules. Keywords: Biologically-active compounds, catalyst-free, four-component reaction, magnetized water, pyrazolopyranopyrimidine, promoting medium.
In this work, a simple, green, and transition metal-free approach to the N -arylation of secondary amines with aryl halides in magnetized distilled water (MDW), as solvent, is introduced.
Background: The design of biologically-active compounds is a challenging viewpoint in medicinal chemistry, and pyrazoles play crucial role as molecules. Keywords: Boehmite nanoparticle, reusable catalyst, sulfamic acid, pyrazoles.
A new approach is introduced for the construction of a predictive quantitative structure-activity relationship model in which only ligand-receptor (LR) interaction features are used as relevant descriptors. This combines benefit random forest (RF) variable selection method with intrinsic capability artificial neural network (ANN). The information complex was molecular docking most descriptors were selected using RF technique and inputs ANN. proposed ANN (RF-LM-ANN) optimized then evaluated...