A5078963239- Pancreatic function and diabetes
- Glycosylation and Glycoproteins Research
- FOXO transcription factor regulation
- Ubiquitin and proteasome pathways
- Endoplasmic Reticulum Stress and Disease
- Peptidase Inhibition and Analysis
City of Hope
2021-2025
Beckman Research Institute
2021
The most prevalent types of lymphomas are B cell (BCL). Newer therapies for BCL have improved the prognosis many patients. However, approximately 30% with aggressive either remain refractory or ultimately relapse. These patients urgently need other options. This study shows how calcium/calmodulin-dependent protein kinase II delta (CAMKIIδ) is pivotal development. In cells, ablation CAMKIIδ inhibits both lipolysis from lipid droplets and oxidative phosphorylation (OXPHOS). With blocked,...
Abstract B-cell precursor acute lymphoblastic leukemia (BCP-ALL) with mixed-lineage gene rearrangement (MLL-r) is a poor-prognosis subtype for which additional therapeutic targets are urgently needed. Currently no multi omics data set primary MLL r patient cells exists that integrates transcriptomics, proteomics and glycomics to gain an inclusive picture of theranostic targets. Methods We have integrated i) obtain the first BCP-ALL identify molecular signatures distinguish leukemic from...