A5044076448- MRI in cancer diagnosis
- Advanced MRI Techniques and Applications
- Glioma Diagnosis and Treatment
- Lanthanide and Transition Metal Complexes
- Radiomics and Machine Learning in Medical Imaging
- Fetal and Pediatric Neurological Disorders
- Extracellular vesicles in disease
- Immune cells in cancer
- Advanced Neuroimaging Techniques and Applications
- Phagocytosis and Immune Regulation
Lund University
2018-2025
Objectives Early diagnostic separation between glioblastoma (GBM) and solitary metastases (MET) is important for patient management but remains challenging when based on imaging only. The objective of this study was to assess whether amide proton transfer weighted (APTw) MRI alone or combined with dynamic susceptibility contrast (DSC) parameters, including cerebral blood volume (CBV), flow (CBF), leakage parameter (K2) measurements, can differentiate GBM from MET. Methods APTw DSC-MRI were...
We investigated multivoxel proton magnetic resonance spectroscopy (1H-MRS) biometrics for preoperative differentiation and prognosis of patients with brain metastases (MET), low-grade glioma (LGG) high-grade (HGG). In total, 33 (HGG, 14; LGG, 9; 10 MET) were included. 1H-MRS imaging (MRSI) data assessed neurochemical profiles metabolites N-acetyl aspartate (NAA) + NAAG(NAA), Cr PCr(total creatine, tCr), Glu Gln(Glx), lactate (Lac), myo-inositol(Ins), GPC PCho(total choline, tCho), total...
Glioblastoma presents a formidable clinical challenge because of its complex microenvironment. Here, we characterized tumor-associated foam cells (TAFs), type lipid droplet–loaded macrophage, in human glioblastoma. Through extensive analyses patient tumors, together with vitro and vivo investigations, found that TAFs exhibit distinct protumorigenic characteristics related to hypoxia, mesenchymal transition, angiogenesis, impaired phagocytosis, their presence correlates worse outcomes for...
Purpose Radiological assessment of primary brain neoplasms, both high (HGG) and low grade tumors (LGG), based on contrast-enhancement alone can be inaccurate. We evaluated the radiological value amide proton transfer weighted (APTw) MRI as an imaging complement for pre-surgical diagnosis tumors. Methods Twenty-six patients were prospectively; (22 males, 4 females, mean age 55 years, range 26–76 years) underwent at 3T using T1-MPRAGE pre- post-contrast administration, conventional T2w, FLAIR,...
The aim was to evaluate volume, diffusion, and perfusion metrics for better presurgical differentiation between high-grade gliomas (HGG), low-grade (LGG), metastases (MET). For this retrospective study, 43 patients with histologically verified intracranial HGG (n = 18), LGG 10), MET 15) were chosen. Preoperative magnetic resonance data included pre- post-gadolinium contrast-enhanced T1-weighted fluid-attenuated inversion recover, cerebral blood flow (CBF), volume (CBV), fractional...
Tumor-related hyperintensities in high b-value diffusion-weighted imaging (DWI) are radiologically important the workup of gliomas. However, white matter may also appear as hyperintense, which conflate interpretation. To investigate whether DWI with spherical b-tensor encoding (STE) can be used to suppress and enhance conspicuity glioma unrelated matter. Twenty-five patients a tumor at least one pathology-related hyperintensity on underwent conventional MRI 3 T. The was performed both linear...