A5015478589- Bacterial Identification and Susceptibility Testing
- Antimicrobial Resistance in Staphylococcus
- Antibiotic Resistance in Bacteria
- Bacterial Infections and Vaccines
- Bacterial biofilms and quorum sensing
- Antibiotic Use and Resistance
- Pneumonia and Respiratory Infections
- Genomics and Phylogenetic Studies
- Respiratory viral infections research
- Mycobacterium research and diagnosis
- Neonatal and Maternal Infections
- Cardiac, Anesthesia and Surgical Outcomes
- Syphilis Diagnosis and Treatment
- Streptococcal Infections and Treatments
- HIV/AIDS drug development and treatment
- Reproductive tract infections research
- Biosensors and Analytical Detection
- Patient Satisfaction in Healthcare
- Oral microbiology and periodontitis research
- Pharmaceutical Practices and Patient Outcomes
- HIV/AIDS Research and Interventions
- Antibiotics Pharmacokinetics and Efficacy
- Vibrio bacteria research studies
- Antimicrobial agents and applications
- HIV Research and Treatment
The University of Melbourne
2019-2025
Peter Doherty Institute
2019-2025
University of Oxford
2022
Centre for Human Genetics
2022
Museum of Heilongjiang Province
2021
Pinderfields Hospital
2018
Campden BRI (United Kingdom)
1990
Pairwise single nucleotide polymorphisms (SNPs) are a cornerstone of genomic approaches to the inference transmission multidrug-resistant (MDR) organisms in hospitals. However, impact many key analytical on these inferences has not yet been systematically assessed. This study aims make such systematic assessment.We conducted 15-month prospective (2-month pilot phase, 13-month implementation phase), across four hospital networks including eight hospitals Melbourne, VIC, Australia. Patient...
Abstract Vancomycin-resistant Enterococcus faecium (VREfm) is a major nosocomial pathogen. Identifying VREfm transmission dynamics permits targeted interventions, and while genomics increasingly being utilised, methods are not yet standardised or optimised for accuracy. We aimed to develop standardized genomic method identifying putative links. Using comprehensive epidemiological data from cohort of 308 infection colonization cases, we compared multiple approaches quantifying genetic...
Journal Article A conductance‐based surface disinfection test for food hygiene Get access J. T. Holah, Holah Campden Food and Drink Research Association, Chipping Campden, Gloucestershire GL55 6LD, UK Search other works by this author on: Oxford Academic Google Scholar C. Higgs, Higgs S. Robinson, Robinson D. Worthington, Worthington H. Spenceley Letters in Applied Microbiology, Volume 11, Issue 5, 1 November 1990, Pages 255–259, https://doi.org/10.1111/j.1472-765X.1990.tb00175.x Published:...
Current microbiological methods lack the resolution to accurately identify multidrug-resistant organism (MDRO) transmission, however, whole genome sequencing can highly-related patient isolates providing opportunities for precision infection control interventions. We investigated feasibility and potential impact of a prospective multi-centre genomics workflow hospital control.We conducted implementation study across eight Australian hospitals over 15 months (2017,2018), collecting all...
Infections caused by multidrug-resistant organisms (MDROs) are difficult to treat and often life threatening place a burden on the healthcare system. Minimizing transmission of MDROs in hospitals is global priority with genomics proving be powerful tool for identifying MDROs. To optimize utility prospective infection control surveillance, results must available real time, reproducible simple communicate clinicians. Traditional reference-based approaches suffer from several limitations...
Abstract Objectives: To conduct a pilot study implementing combined genomic and epidemiologic surveillance for hospital-acquired multidrug-resistant organisms (MDROs) to predict transmission between patients estimate the local burden of MDRO transmission. Design: Pilot prospective multicenter study. Setting: The was conducted in 8 university hospitals (2,800 beds total) Melbourne, Australia (population 4.8 million), including 4 acute-care, 1 specialist cancer care, 3 subacute-care hospitals....
Healthcare associated infections caused by vancomycin-resistant Enterococcus faecium (VREfm) have a major impact on health outcomes. VREfm is difficult to treat because of intrinsic and acquired resistance many clinically used antimicrobials, with daptomycin being one the few last line therapeutic options for treating multidrug-resistant VREfm. The emergence daptomycin-resistant therefore serious clinical concern. Despite this, that patient outcomes not clearly defined knowledge mechanisms...
Streptococcus pneumoniae is a major human pathogen and can cause range of conditions from asymptomatic colonization to invasive pneumococcal disease (IPD). The epidemiology distribution IPD-causing serotypes in Australia has undergone large changes following the introduction 7-valent conjugate vaccine (PCV) 2005 13-valent PCV 2011. In this study, provide contemporary understanding IPD causing population Victoria, Australia, we aimed examine structure prevalence antimicrobial resistance using...
Among genes present in all group A streptococci (GAS), those encoding M-fibril and T-pilus proteins display the highest levels of sequence diversity, giving rise to two primary serological typing schemes historically used define strain. new genotyping scheme for pilin adhesin backbone is developed and, when combined with emm typing, provides an account global GAS strain population. Cluster analysis based on nucleotide similarity assigns most T-serotypes discrete clusters, yet established...
Streptococcus pneumoniae is a major human pathogen with high burden of disease. Non-invasive isolates (those found in non-sterile sites) are thought to be key source invasive sterile and reservoir anti-microbial resistance (AMR) determinants. Despite this, pneumococcal surveillance has almost exclusively focused on isolates. We aimed compare contemporaneous non-invasive isolate populations understand how they interact identify differences AMR gene distribution. used combination whole-genome...
Oral azithromycin given during labour reduces carriage of bacteria responsible for neonatal sepsis, including Staphylococcus aureus. However, there is concern that this may promote drug resistance.Here, we combine genomic and epidemiological data on S. aureus isolated from mothers babies in a randomized intra-partum trial (PregnAnZI) to describe bacterial population dynamics resistance mechanisms.Participants both arms the trial, who carried day 3 28 samples post-intervention, were included....
Abstract Background Multidrug-resistant organisms (MDROs) disproportionately affect hospitalized patients due to the combination of comorbidities, frequent antimicrobial use, and in-hospital MDRO transmission. Identification transmission by hospital microbiology laboratories is difficult limitations existing typing methods. Methods We conducted a prospective multicenter genomics implementation study (8 hospitals, 2800 beds) from 24 th April 18 June 2017 in Melbourne, Australia. Clinical...
ABSTRACT Background Pairwise single nucleotide polymorphisms (SNPs) are a cornerstone for genomic approaches to multidrug-resistant organisms (MDROs) transmission inference in hospitals. However, the impact of key analysis parameters on these inferences has not been systematically analysed. Methods We conducted multi-hospital 15-month prospective study, sequencing 1537 MDRO genomes comparison; methicillin-resistant Staphylococcus aureus , vancomycin-resistant Enterococcus faecium and...
Carbapenemase-producing Enterobacterales (CPE) are an emerging public health concern globally as they resistant to a broad spectrum of antibiotics. Colonisation with CPE typically requires patients be managed under ‘contact precautions’, which creates additional physical bed demands in healthcare facilities. This study examined the potential impact revised isolation guidelines introduced late 2023 Victoria, Australia, that relaxed requirement for indefinite CPE-colonised contact precautions,...
Background: Current microbiological methods lack the resolution to accurately identify multidrug-resistant organism (MDRO) transmission, however, whole genome sequencing can highly-related patient isolates providing opportunities for precision infection control interventions. We investigated feasibility and potential impact of a prospective multi-centre genomics workflow hospital control.Methods: conducted implementation study across eight Australian hospitals over 15 months (2017-2018),...
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1392 Chronic heart failure -Treatment higher EF, CO, and GFR, lower SVR plasma renin activity without lowering BP.The CD group also showed significant downregulation of genes related to inflammation apoptosis pathways in both the kidney compared untreated.Both L-CD H-CD increased cGMP levels for 2 hours after drug injection those more prolonged increases than group.BP was unchanged but BP tended be 18 this not significant.Plasma NT-proBNP did show any change following similar BP.No adverse...