A5056021442- Endometrial and Cervical Cancer Treatments
- Ovarian cancer diagnosis and treatment
- Cervical Cancer and HPV Research
- Genetic factors in colorectal cancer
- Colorectal and Anal Carcinomas
- Sarcoma Diagnosis and Treatment
- Intraperitoneal and Appendiceal Malignancies
- Colorectal Cancer Screening and Detection
- Cancer Genomics and Diagnostics
- BRCA gene mutations in cancer
- Cancer-related Molecular Pathways
- Palliative Care and End-of-Life Issues
- Reproductive Biology and Fertility
- Molecular Biology Techniques and Applications
- Cancer Risks and Factors
- Uterine Myomas and Treatments
- Economic and Financial Impacts of Cancer
- Metastasis and carcinoma case studies
- Endometriosis Research and Treatment
- Angiogenesis and VEGF in Cancer
- Epigenetics and DNA Methylation
- Multiple and Secondary Primary Cancers
- Pancreatic and Hepatic Oncology Research
- Vascular Tumors and Angiosarcomas
- Body Contouring and Surgery
Billings Clinic
2007-2016
University of Oklahoma Health Sciences Center
2015
University of California, San Francisco
2015
Memorial Sloan Kettering Cancer Center
1999-2015
University of North Carolina at Chapel Hill
2015
Norton Healthcare
2015
Christiana Care Health System
2015
Washington University in St. Louis
2002-2015
Kaiser Permanente
2015
Saint Louis University
2005-2015
Endometrial cancer is the most common gynecologic malignancy in United States and frequent extracolonic tumor hereditary nonpolyposis colorectal (HNPCC). HNPCC patients have inherited defects DNA mismatch repair microsatellite instability (MSI) phenotype. Sporadic endometrial cancers also exhibit MSI, usually associated with methylation of MLH1 promoter. Germ-line MSH6 mutations, which are rare HNPCC, been reported several families multiple members affected carcinoma. We reasoned that...
Removal of the parametrial soft tissue is recommended for patients with cervical cancer undergoing radical hysterectomy. Parametrectomy results in significant morbidity. The objective study was to determine factors predictive tumor spread and define a subset at low risk disease.Patients invasive who underwent hysterectomy from 1989-2005 were examined. Analysis performed associated spread. Survival estimates determined using Kaplan-Meier method.A total 594 identified. Parametrial metastases...
Most studies of microsatellite instability (MSI) and outcomes in endometrial cancer patients have included varied histologic subtypes. Nonetheless, MSI occurs almost exclusively endometrioid tumors. The impact on with is controversial. We sought to determine whether MLH1 methylation are associated clinicopathologic variables survival a large series carcinomas the type.Tumor samples, blood, data were prospectively collected analyzed for 446 carcinomas. was determined using five National...
Increasing evidence has documented the value of positron emission tomography (PET) in oncology, but only limited data are available comparing PET findings with pathologic status regional lymph nodes patients cervical carcinoma. The objective this study was to determine sensitivity and specificity detecting node metastasis women early-stage carcinoma.The authors performed a retrospective review all Stage IA-IIA carcinoma who underwent before surgery from 1999 2004. correlated...
Xenbase (www.xenbase.org) is a model organism database integrating diverse array of biological and genomic data on the frogs, Xenopus laevis (Silurana) tropicalis. Data collected from other databases, high-throughput screens scientific literature integrated into number modules covering subjects such as community, literature, gene analysis. Gene pages are automatically assembled piped Entrez Gene, Gurdon Institute, JGI, Metazome, MGI, OMIM, PubMed, Unigene, Zfin, commercial suppliers others....
Abstract BACKGROUND The study was undertaken to determine the safety and efficacy of monoclonal, antivascular endothelial growth factor antibody bevacizumab in combination with cytotoxic chemotherapy for women platinum‐refractory ovarian cancer. METHODS A retrospective analysis who received a agent performed. Response determined by measurable disease or assessment serial cancer antigen (CA) 125 measurements. RESULTS Twenty‐three patients were identified. heavily pretreated median 7 prior...
Abstract BACKGROUND Advanced age often is considered a poor prognostic factor for cervical carcinoma. The authors investigated the patterns of care and treatment outcomes elderly women with METHODS A hospital‐based tumor registry was used to identify patients invasive carcinoma who were treated between 1986 2003. Patients divided into 2 cohorts: < 70 years ≥ years. Survival examined using Kaplan–Meier method. Single multivariate Cox proportional hazards modeling estimate hazard ratios 95%...
In Brief Background: Although the incidence of cervical dysplasia in adolescents is increasing, a paucity data exists regarding outcomes with Pap test abnormalities. We determined natural history and outcome low-grade squamous intraepithelial lesions (LSIL) high-grade (HSIL). Methods: A review all women aged 18 years or younger cytologic diagnosis LSIL HSIL between 1997 2003 was performed. Follow-up histologic samples were evaluated. The most significant abnormality recorded for each...
PURPOSE Mutations in the DNA damage response gene ATR (exon 10 A10 mononucleotide repeat) have been previously described endometrial and other cancers with defective mismatch repair. In vitro studies showed that cancer cell lines repeat tract truncating mutations a failure ATR-dependent response. Cell carrying fail to trigger Chk1 activation ionizing radiation topoisomerase inhibitors. We sought determine frequency clinicopathologic significance of patients endometrioid cancer. PATIENTS AND...
While bevacizumab has shown activity in recurrent ovarian cancer, a higher than expected incidence of bowel perforations been reported recent trials. We sought to determine factors associated with toxicity and tumor response patients relapsed cancer treated bevacizumab. A retrospective review was undertaken. Response determined radiographically through CA125 measurements. Statistical analysis performed. Sixty-two eligible were identified. The cohort had received median 5 prior chemotherapy...
Early detection of epithelial ovarian carcinoma through screening and symptom has failed to reduce mortality from this lethal malignancy. The only available strategy likely cancer is prevention. This review summarizes evidence that implementation several prevention strategies can substantially cancer. Potential recommended by the Society Gynecologic risk are discussed. Recommendations based on analysis current literature. • A key aim preventive identify treat women at hereditary increased...