A5068203358- Single-cell and spatial transcriptomics
- Genetic Associations and Epidemiology
- Immune Cell Function and Interaction
- Phagocytosis and Immune Regulation
- Genomics and Phylogenetic Studies
- Chromatin Remodeling and Cancer
- Neuroscience and Neural Engineering
- Circular RNAs in diseases
- Genomics and Rare Diseases
- Cell Image Analysis Techniques
- Cancer Genomics and Diagnostics
- Molecular Communication and Nanonetworks
- Genomic variations and chromosomal abnormalities
- Cancer Mechanisms and Therapy
University Hospital Münster
2025
University of Münster
2022-2025
Universitat Autònoma de Barcelona
2021
Hepatoblastoma is the most common pediatric cancer of liver and majority cases display activating mutations in Wnt/β-catenin pathway. Understanding complex milieu tumor microenvironment has resulted promising new therapies for adult cancers, but similar approaches cancers are still lacking. We aimed to provide a comprehensive analysis hepatoblastoma unveiling its spatial architecture key signaling mechanisms. Single-cell/-nucleus RNA-seq (n=15), transcriptomics (n=22), multiplex...
Abstract Background A thorough analysis of clonal evolution commonly requires integration diverse sources data (e.g., karyotyping, next-generation sequencing, and clinical information). Subsequent to actual reconstruction evolution, detailed interpretation the results are essential. Often, however, only few tumor samples per patient available. Thus, information on development therapy effect may be incomplete. Furthermore, biallelic events—considered high relevance with respect disease...
Abstract INTRODUCTION Exploring tumor-neuronal interactions is essential for comprehending brain tumor proliferation, chemotherapy resistance, and patient survival. While glioma research has made significant strides, our understanding of in pediatric tumors, notably Embryonal Tumors with Multilayered Rosettes (ETMRs), remains limited. METHODS To elucidate ETMRs, we developed a 3D model by co-aggregating the human ETMR cell line BT-183 induced pluripotent stem cells (iPSCs) allowing them to...
Adaptive challenges that humans faced as they expanded across the globe left specific molecular footprints can be decoded in our today's genomes. Different sets of metrics are used to identify genomic regions have undergone selection. However, there fewer methods capable pinpointing allele ultimately responsible for this Here, we present PopHumanVar, an interactive online application is designed facilitate exploration and thorough analysis candidate by integrating both functional population...