A5071996594- Orthopaedic implants and arthroplasty
- Total Knee Arthroplasty Outcomes
- Orthopedic Infections and Treatments
- Sarcoma Diagnosis and Treatment
- Bone Tumor Diagnosis and Treatments
- Management of metastatic bone disease
- Bone and Joint Diseases
- Hip disorders and treatments
- Oral and Maxillofacial Pathology
- Knee injuries and reconstruction techniques
- Bone fractures and treatments
- Bone health and treatments
- Microscopic Colitis
- Venous Thromboembolism Diagnosis and Management
- Clostridium difficile and Clostridium perfringens research
- Cardiac tumors and thrombi
- Musculoskeletal synovial abnormalities and treatments
- Nerve Injury and Rehabilitation
- Hip and Femur Fractures
- Economic and Environmental Valuation
- Orthopedic Surgery and Rehabilitation
- Reconstructive Surgery and Microvascular Techniques
- Spondyloarthritis Studies and Treatments
- Surgical site infection prevention
- Blood transfusion and management
Healthpoint
2023-2024
Khalifa University of Science and Technology
2023-2024
Queen Mary University of London
2019-2024
Edward Via College of Osteopathic Medicine
2024
Royal London Hospital
2016-2022
Barts Health NHS Trust
2016-2021
Imperial College London
2019
Stanford University
2018
Creative Research Enterprises (United States)
2017-2018
Hillingdon Hospitals NHS Foundation Trust
2018
Aims The purpose of this study was to compare the long-term results primary total hip arthroplasty (THA) in young patients using either a conventional (CPE) or highly cross-linked (HXLPE) polyethylene liner terms functional outcome, incidence osteolysis, radiological wear and rate revision. Methods We included all between ages 45 65 years who, January 2000 December 2001, had undergone THA for osteoarthritis at our hospital CPE HXLPE acetabular 28 mm cobalt-chrome femoral head. From 160...
Nucleic acid amplification testing (NAAT) is increasingly being adopted for diagnosis of Clostridium difficile infection (CDI). Data from 3 states conducting population-based CDI surveillance showed increases ranging 43% to 67% in incidence attributable changing toxin enzyme immunoassays NAAT. requires adjustment methods.
Surgical resection margins are reportedly the most important predictor of survival and local recurrence with sacral chordomas. We examined relevance invasion surrounding posterior pelvic musculature (piriformis gluteus maximus) at initial diagnosis to after sacrectomy. retrospectively reviewed 18 patients histologically verified chordoma seen our institution between 1998 2005. There were 14 men four women a mean age 65.1 years (range, 31-78 years). The average overall followup was 4.4 0.5-10...
Segmental resection of malignant bone disease in the femoral diaphysis with subsequent limb reconstruction is a major undertaking. This retrospective review 23 patients who had undergone salvage by endoprosthetic replacement for primary tumour between 1989 and 2005. There were 16 males seven females, mean age 41.3 years (10 to 68). The overall follow-up was 97 months (3 240), 120 (42 240) living patients. cumulative patient survival 77% (95% confidence interval 63% 95%) at ten years....
The best method of reconstruction after resection malignant tumours the tibial diaphysis is unknown. In absence any long-term studies analysing results intercalary endoprosthetic replacement, we present a retrospective review 18 patients who underwent limb salvage using diaphyseal replacement following excision bone tumour. There were ten men and eight women with mean age 42.5 years (16 to 76). Mean follow-up was 58.5 months (20 141) for all 69.3 12 still alive. Cumulative patient survival...
The increasing prevalence of obesity has resulted in a marked increase the number total hip arthroplasties (THAs) carried out patients with high body mass index (BMI). THA morbidly obese is often technically challenging owing to associated co-morbidities and anatomical factors. Furthermore, long-term clinical functional outcomes procedure these are not clear. aim this systematic review was compare failure rate versus non-obese patients. A literature search PubMed, EMBASE PubMed Central...
Endoprosthetic replacement of the distal tibia and ankle joint for a primary bone tumour is rarely attempted technically challenging procedure. We report outcome six patients treated between 1981 2007. There were four males two females, with mean age 43.5 years (15 to 75), follow-up 9.6 (1 27). No patient developed local recurrence or metastasis. Two went on have below-knee amputation persistent infection after 16 months 31). The who retained their endoprosthesis had musculoskeletal society...
We undertook a retrospective review of 33 patients who underwent total femoral endoprosthetic replacement as limb salvage following excision malignant bone tumour. In 22 this was performed primary procedure resection for disease. Revision to required in 11 failed segmental or allograft reconstruction. There were with tumours, and three had metastatic lesions. The mean age the 31 years (5 68). follow-up 4.2 (9 months 16.4 years). At five survival implants 100%, removal endpoint 56% where...
Between 1988 and 2006, 18 patients had a custom-made endoprosthetic replacement of the distal humerus for bone tumours at our institution. There were 11 primary malignant neoplasms, six secondary deposits, one benign aggressive tumour. The mean follow-up was 4.4 years (1 to 18.2). Complications occurred in nine included aseptic loosening three (16.6%), local recurrence two (11%), infection neuropraxia radial nerve (5.5%) peri-prosthetic fracture (5.5%). Excision inadequate four (22%), all...
Dedifferentiated chordoma is a rare and aggressive variant of the conventional tumour in which an area undergoes transformation to high-grade lesion, typically fibrous histiocytoma, fibrosarcoma, rarely, osteosarcoma or rhabdomyosarcoma. The dedifferentiated component dictates overall survival, with smaller areas dedifferentiation carrying more favourable prognosis. Although it commonly diagnosed recurrences following radiotherapy, there have been few reports spontaneous development. We...
The long term biological effects of wear products following total hip arthroplasty (THA) are unclear. However, the indications for THA expanding, with increasingly younger patients undergoing procedure. This prospective, randomised study compared two groups after being to receive one different bearing surfaces: metal-on-polyethylene (MoP) n = 22 and metal-on-metal (MoM) 23. We investigated relationship between three variables: surface (MoP vs MoM), whole blood levels chromium (Cr) cobalt...
Total knee arthroplasty (TKA) in patients affected by poliomyelitis is technically challenging owing to abnormal anatomical features including articular and metaphyseal angular deformities, external rotation of the tibia, excessive valgus alignment, bone loss, narrowness femoral tibial canals, impaired quadriceps strength, flexion contractures, genu recurvatum ligamentous laxity. Little information available regarding results complications TKA this group patients. We carried out a systematic...
Background Addressing bone loss in revision TKA is challenging despite the array of options to reconstruct deficient bone. Biologic reconstruction using morselized loosely-packed graft potentially allows for augmentation residual stock while offering physiologic load transfer. However it unclear whether reconstructions are durable. Questions/purposes We therefore sought determine (1) survivorship and complications, (2) function, (3) radiographic findings cementless combination with osseous...