A5101541194- Helicobacter pylori-related gastroenterology studies
- Dementia and Cognitive Impairment Research
- Aging, Health, and Disability
- Clinical practice guidelines implementation
- Health Systems, Economic Evaluations, Quality of Life
- Mosquito-borne diseases and control
- Public Health and Social Inequalities
- Colorectal Cancer Screening and Detection
- Alzheimer's disease research and treatments
- Health and Medical Education
- Gastrointestinal motility and disorders
- Gastrointestinal disorders and treatments
- Gastric Cancer Management and Outcomes
- Microscopic Colitis
- Liver Disease Diagnosis and Treatment
- Ethics and bioethics in healthcare
- Esophageal and GI Pathology
- Epigenetics and DNA Methylation
- Peripheral Neuropathies and Disorders
- Pancreatic and Hepatic Oncology Research
- Medical research and treatments
- Health Policy Implementation Science
- Health Sciences Research and Education
- Genetic factors in colorectal cancer
- Inflammatory Bowel Disease
Universidad Nacional de Colombia
2015-2025
Instituto de Neurologia Y Neurocirugia
2025
Hospital Universitario Nacional de Colombia
2016-2021
Hospital General Universitario de Ciudad Real
2000
The 2021 Adult and Pediatric Anticoagulation Guidelines for patients on extracorporeal membrane oxygenation (ECMO) recommend a target partial thromboplastin time (PTT) between 60 85 seconds when unfractionated heparin (UFH) is administered as an anticoagulant. However, institutions may develop their own protocols in the absence of solid evidence regarding patient anticoagulation during ECMO support. We aimed to determine association maintenance with different PTT ranges among receiving UFH...
Objetivo: Generar recomendaciones basadas en la evidencia, para prevención primaria y secundaria, el tratamiento de las lesiones preneoplásicas diagnóstico temprano del cáncer gástrico población adulta, con propósito reducir carga enfermedad.
 Materiales métodos: El grupo desarrollador estuvo integrado por profesionales salud tomadores decisiones. Se construyeron preguntas clínicas contestables se realizó graduación los desenlaces. elaboró busqueda información MEDLINE; EMBASE CENTRAL,...
There is still doubt as to the number of species freshwater Chilean ichthyofauna, 64 % which have conservation problems.One groups that silversides genus Basilichthys.Three morphological this been described in Chile with disjoint distributions: Basilichthys semotilus, B. microlepidotus and australis; latter two overlap distribution only Aconcagua River are not easily distinguishable by meristic characters.In order evaluate effi cacy identifi cation these molecular techniques, we analyzed...
Few methodological studies address the prioritization of clinical topics for development Clinical Practice Guidelines (CPGs). The aim this study was to validate a methodology Priority Determination Topics (PDT) CPGs. Firstly, we developed an instrument PDT with 41 criteria that were grouped under 10 domains, based on comprehensive systematic search. Secondly, performed survey stakeholders involved in CPGs development, and end users guidelines, using instrument. Thirdly, pilot testing...
Biomarkers are essential for identification of individuals at high risk mild cognitive impairment (MCI) potential prevention dementia. We investigated DNA methylation in the APOE gene and apolipoprotein E (ApoE) plasma levels as MCI biomarkers Colombian subjects with controls.In total, 100 participants were included (71% women; average age, 70 years; range, 43⁻91 years). was diagnosed by neuropsychological testing, medical social history, activities daily living, symptoms neuroimaging. Using...
Introduction: Late-onset Alzheimer disease (LOAD) is the most common dementia worldwide. APOE -ɛ4 and BIN1 (Bridging Integrator 1) have been implicated in pathogenesis of this disease, but, although DNA methylation dinucleotide CpGs gene influences alterations, it has not studied Hispanics. Objective: The objective study was to evaluate 3′ intergenic region patterns a Colombian sample LOAD patients. Methods: A case-control conducted 50 individuals with age-sex matched controls determine...
Alzheimer disease risk polymorphisms have been studied in patients with dementia, but not yet explored mild cognitive impairment (MCI) our population; nor they addressed relation to variables, which can be predictive biomarkers of disease.To evaluate performance and presence the genes SORL1(rs11218304), PVRL2(rs6859), CR1(rs6656401), TOMM40(rs2075650), APOE (isoforms ε2, ε3, ε4), PICALM(rs3851179), GWAS_14q(rs11622883), BIN1(rs744373), CLU(rs227959 rs11136000) MCI healthy individuals.We...
Introduction. Cognitive disorders are a clinical and research challenge; in particular, the mild cognitive disorder (MiCD) requires diagnostic suspicion tools with adequate performance for its detection. The objective of this study was validation short test (CATest) detection MiCD population 50 years or more. Methods. A accuracy assembled performed prospective cohort. consecutive sample 200 Colombian subjects who represented whole spectrum condition interest allowed us to reach objective....
Los polimorfismos de riesgo para el desarrollo enfermedad Alzheimer (se han estudiado en pacientes con demencia, pero aún no se explorado trastorno neurocognitivo leve (TNL) nuestra población, ni considerado relación variables cognitivas, las cuales pueden ser biomarcadores predictivos enfermedad. Evaluar los desempeños cognitivos y genes SORL1(rs11218304), PVRL2(rs6859), CR1(rs6656401), TOMM40(rs2075650), APOE(isoformas ɛ2, ɛ3, ɛ4), PICALM(rs3851179), GWAS_14q(rs11622883), BIN(rs744373),...
The INECO Frontal Screening (IFS) was designed as an efficient evaluation of the executive function. IFS has shown to sensitively differentiate healthy from dementia population. Although originally created in Spanish, it is necessary validate its use a new Spanish population, since recent studies have clear differences daily same language different settings. Our objective Colombian healthy, mild cognitive impairment (MCI) and Alzheimer disease (AD) populations. Patients with AD MCI that were...
La enfermedad de Alzheimer (EA) es la más común las demencias; un problema salud pública en el Mundo, pero Colombia no hace parte prioridades del Estado. El presente ensayo aborda cómo sistema colombiano reconoce, identifica y provee servicios a los pacientes con EA, desde una óptica Justicia Social. En primera medida se evalúa información generada por academia, su correlato normativa vigente articulación. Se explora lógica utilitarista incentivo maximización ganancias aseguradores esto ha...