A5034903697- Bone Tissue Engineering Materials
- PI3K/AKT/mTOR signaling in cancer
- Lung Cancer Treatments and Mutations
- Melanoma and MAPK Pathways
- Thyroid Cancer Diagnosis and Treatment
- Cancer Research and Treatments
- Pancreatic and Hepatic Oncology Research
- Glycosylation and Glycoproteins Research
- Cancer-related Molecular Pathways
- Cancer Cells and Metastasis
- Chronic Myeloid Leukemia Treatments
- Advanced X-ray Imaging Techniques
- Vitamin D Research Studies
- Protein Kinase Regulation and GTPase Signaling
- MicroRNA in disease regulation
- Cancer, Hypoxia, and Metabolism
- TGF-β signaling in diseases
- Genetics, Bioinformatics, and Biomedical Research
- Neuroblastoma Research and Treatments
- Ferroptosis and cancer prognosis
- Orthopaedic implants and arthroplasty
- Endoplasmic Reticulum Stress and Disease
- Genetic Syndromes and Imprinting
- Bone and Dental Protein Studies
- Soft tissue tumor case studies
Cornell University
2017-2019
Brigham and Women's Hospital
2010-2011
Harvard University
2010-2011
Dana-Farber Cancer Institute
2010-2011
Massachusetts General Hospital
2011
Broad Institute
2010-2011
Massachusetts Institute of Technology
2010
We previously identified a region of recurrent amplification on chromosome 22q11.21 in subset primary lung adenocarcinomas. Here we show that CRKL, encoding for an adaptor protein, is amplified and overexpressed non-small cell cancer (NSCLC) cells harbor amplifications. Overexpression CRKL immortalized human airway epithelial promoted anchorage-independent growth tumorigenicity. Oncogenic activates the SOS1-RAS-RAF-ERK SRC-C3G-RAP1 pathways. Suppression NSCLC amplifications induced death....
Although autophagy is generally considered a prosurvival mechanism that preserves viability, there evidence it could drive an alternative programmed cell death pathway in cells with defects apoptosis. Because the inhibition of autophagic activity promotes resistance to both chemotherapy and external beam radiation papillary thyroid cancer (PTC), we determined if RAD001, potent activator autophagy, improves efficacy either therapy. We found RAD001 increased expression level light chain 3-II,...
Skeletal metastases, the leading cause of death in advanced breast cancer patients, depend on tumor cell interactions with mineralized bone extracellular matrix. Bone mineral is largely composed hydroxyapatite (HA) nanocrystals physicochemical properties that vary significantly by anatomical location, age, and pathology. However, it remains unclear whether regions typically targeted metastatic feature distinct HA materials properties. Here we combined high-resolution X-ray scattering...
Low tumoral expression of mitogen-inducible gene-6 (Mig-6) is associated with papillary thyroid cancer (PTC) recurrence after thyroidectomy. We hypothesize that Mig-6 behaves as a tumor suppressor in PTC. and promoter methylation status were compared 31 PTC specimens matched normal tissue from the same patient. The impact loss gain function on nuclear factor κ-light-chain-enhancer activated B cells (NF-κB) activation, global tyrosine kinase phosphorylation, cellular invasion was determined...
Abstract Tyrosine kinases (TKs) are frequently, aberrantly activated in human cancers. Moreover, they could be easily inhibited by small molecules and thereby represent excellent therapeutic targets. Here, to understand the role of TK signaling cancer development maintenance, identify novel inhibitor based strategies, we have systematically profiled tyrosine kinase activation events In our previously published study, developed a high-throughput, multiplex antibody-based assay capable...
Abstract Tyrosine kinases (TKs) are frequently, aberrantly activated in human cancers. Moreover, they could be easily inhibited by small molecules and thereby represent excellent therapeutic targets. Here, our project aims to systematically identify activated, essential TKs In previously published study, we have developed a high-throughput, multiplex antibody-based assay capable of identifying tyrosine regardless their mode activation. Using this approach, profiled 130 established cancer...