A5072328168- Pancreatic and Hepatic Oncology Research
- Cardiac, Anesthesia and Surgical Outcomes
- Peptidase Inhibition and Analysis
- Enhanced Recovery After Surgery
- Diversity and Career in Medicine
- Pancreatitis Pathology and Treatment
- Clinical Nutrition and Gastroenterology
- Surgical Simulation and Training
- Cell Adhesion Molecules Research
- Tissue Engineering and Regenerative Medicine
- Gastric Cancer Management and Outcomes
- Hospital Admissions and Outcomes
- Radiopharmaceutical Chemistry and Applications
- Colorectal Cancer Surgical Treatments
- Gallbladder and Bile Duct Disorders
- Monoclonal and Polyclonal Antibodies Research
- Colorectal Cancer Screening and Detection
- Cancer Genomics and Diagnostics
- Diet and metabolism studies
- Thyroid Cancer Diagnosis and Treatment
- RNA modifications and cancer
- Galectins and Cancer Biology
- Innovations in Medical Education
- Anesthesia and Pain Management
- RNA Interference and Gene Delivery
Brigham and Women's Hospital
2016-2025
Harvard University
2015-2025
VA Boston Healthcare System
2012-2024
Boston Medical Center
2020-2021
Boston University
2020-2021
Beth Israel Deaconess Medical Center
2020
New York University
2020
University of California, San Diego
2018
Dana-Farber Cancer Institute
2009-2010
Massachusetts Institute of Technology
1989-2010
Objective To analyze the impact of a conservative strategy management in patients with necrotizing pancreatitis, reserving intervention for documented infection or late complications organized necrosis. Summary Background Data The role surgery sterile pancreatic necrosis remains controversial. Although approach is being increasingly used, few studies have evaluated this when applied to entire spectrum pancreatitis. Methods authors reviewed 1,110 consecutive acute pancreatitis managed at...
We previously reported that organ failure occurs in 50% of patients with necrotizing pancreatitis, extended pancreatic necrosis (greater than necrosis) is not associated an increased prevalence or infected necrosis, and the similar sterile necrosis. AIMS To analyze these relations a larger group to evaluate other factors might have prognostic significance.We reviewed 1,110 consecutive cases acute pancreatitis between January 1, 1995, 2000. Necrosis was documented by contrast-enhanced CT. A...
Abstract Purpose: We tested the hypotheses that Src tyrosine kinase overactivity represents a chemoresistance mechanism and inhibition may enhance gemcitabine cytotoxicity in pancreatic adenocarcinoma cells. Experimental Design: Pancreatic cells PANC1, MiaPaCa2, Capan2, BxPC3, PANC1GemRes, stably gemcitabine-resistant subline of were exposed to combinations inhibitor 4-amino-5-(4-chlorophenyl)-7-(t-butyl)pyrazolo[3,4-d]pyrimidine (PP2). expression, phosphorylation (Tyr-416), activity...
<h3>Importance</h3> Socioeconomic variables including sex, race, ethnicity, marital status, and insurance status are associated with survival in pancreatic cancer. It remains unknown exactly how these influence survival, whether they affect stage at presentation or receipt of treatment independently outcomes. <h3>Objectives</h3> To investigate the relationship between socioeconomic factors odds resection early-stage, resectable adenocarcinoma to determine same were patients who underwent...
Abstract Accumulating evidence suggests an important role for cyclooxygenase-2 (COX-2) in the pathogenesis of a wide range malignancies. Here we tested hypothesis that COX-2 product prostaglandin E2 (PGE2) increases cellular invasive potential by inducing matrix metalloproteinase-2 (MMP-2) expression and activity through extracellular signal-regulated kinase (ERK)/Ets-1-dependent mechanism pancreatic cancer. PANC-1 MIAPaCa-2 cancer cells were treated with PGE2 or rofecoxib, selective...
To determine the impact of work hour limitations imposed by 405 (Bell) Regulations as perceived general surgery residents in New York State.New Accreditation Council for Graduate Medical Education (ACGME) requirements on resident duty hours are scheduled to undergo nationwide implementation July 2003. State regulations stipulating similar have already been enacted York.A statewide survey enrolled residencies was administered.Most respondents reported compliance with their residency programs,...
Although autophagy is generally considered a prosurvival mechanism that preserves viability, there evidence it could drive an alternative programmed cell death pathway in cells with defects apoptosis. Because the inhibition of autophagic activity promotes resistance to both chemotherapy and external beam radiation papillary thyroid cancer (PTC), we determined if RAD001, potent activator autophagy, improves efficacy either therapy. We found RAD001 increased expression level light chain 3-II,...
Enhanced Recovery After Surgery (ERAS®) protocols are the cornerstone of improved recovery after colorectal surgery. Their implementation leads to reduced morbidity and shorter hospital stays while attenuating surgical stress response. Multimodal analgesia is an important part ERAS protocols. We compared contrasted from 15 institutions test our hypothesis that there a fundamental consensus among them.ERAS for open laparoscopic surgery were different healthcare facilities. examined each...
RNA interference (RNAi), mediated by small interfering (siRNA), silences genes with a high degree of specificity and potentially represents general approach for molecularly targeted anticancer therapy. The aim this study was to evaluate the ability systemically administered siRNA silence gene expression in vivo assess effect on tumor growth using murine pancreatic adenocarcinoma xenograft model.Carcinoembryonic antigen-related cell adhesion molecule 6 (CEACAM6) is widely overexpressed human...