A5055577517- Career Development and Diversity
- Education Systems and Policy
- Reflective Practices in Education
- Diverse Educational Innovations Studies
- Counseling Practices and Supervision
- Higher Education and Employability
- Asymmetric Synthesis and Catalysis
- Teacher Education and Leadership Studies
- Synthesis of β-Lactam Compounds
- Synthetic Organic Chemistry Methods
- Genomics and Chromatin Dynamics
- Phenothiazines and Benzothiazines Synthesis and Activities
- Collaborative Teaching and Inclusion
- Antibiotics Pharmacokinetics and Efficacy
- Education and Technology Integration
- Student Assessment and Feedback
- Teacher Professional Development and Motivation
- Higher Education Learning Practices
- CRISPR and Genetic Engineering
- Education and Critical Thinking Development
- Epigenetics and DNA Methylation
- Human Resource Development and Performance Evaluation
- Pharmacological Receptor Mechanisms and Effects
- Advanced Computational Techniques and Applications
- RNA Research and Splicing
University of Michigan
2020-2025
Institute of Human Genetics
2024
Syracuse University
2022
Royal College of Surgeons in Ireland
2017
Sunderland Royal Hospital
2011
City Hospital
2011
Wright State University
1991-2010
Eli Lilly (United States)
1983-1996
University of South Carolina
1993-1995
Indiana University of Pennsylvania
1986-1988
ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTChemistry of cephalosporin antibiotics. XXI. Conversion penicillins to cephalexinRobert R. Chauvette, Pamela A. Pennington, Charles W. Ryan, Robin D. G. Cooper, Felicitas L. Jose, Ian Glaiby Wright, Earle M. Van Heyningen, and George HuffmanCite this: J. Org. Chem. 1971, 36, 9, 1259–1267Publication Date (Print):May 1, 1971Publication History Published online1 May 2002Published inissue 1...
ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTChemistry of Cephalosporin Antibiotics. II. Preparation a New Class Antibiotics and the Relation Structure to ActivityRobert R. Chauvette, Edwin H. Flynn, Bill G. Jackson, E. Lavagnino, Robert B. Morin, Richard A. Mueller, P. Pioch, W. Roeske, C. Ryan, John L. Spencer, Earle. Van HeyningenCite this: J. Am. Chem. Soc. 1962, 84, 17, 3401–3402Publication Date (Print):September 1, 1962Publication History Published online1 May 2002Published inissue 1...
Abstract Chromatin architecture, a key regulator of gene expression, can be inferred using chromatin contact data from chromosome conformation capture, or Hi-C. However, classical Hi-C does not preserve multi-way contacts. Here we use long sequencing reads to map genome-wide contacts and investigate higher order organization in the human genome. We hypergraph theory for representation analysis, quantify structures neonatal fibroblasts, biopsied adult B lymphocytes. By integrating with...
ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTCannabinoids. 3. Synthetic approaches to 9-ketocannabinoids. Total synthesis of nabiloneRobert A. Archer, W. B. Blanchard, William Day, Douglas Johnson, E. R. Lavagnino, C. Ryan, and Jack BaldwinCite this: J. Org. Chem. 1977, 42, 13, 2277–2284Publication Date (Print):June 1, 1977Publication History Published online1 May 2002Published inissue 1 June...
ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTChemistry of cephalosporin antibiotics. XIII. Deacetoxycephalosporins. Synthesis cephalexin and some analogsCharles W. Ryan, R. L. Simon, Earle M. Van HeyningenCite this: J. Med. Chem. 1969, 12, 2, 310–313Publication Date (Print):March 1, 1969Publication History Published online1 May 2002Published inissue 1 March 1969https://doi.org/10.1021/jm00302a026RIGHTS & PERMISSIONSArticle Views386Altmetric-Citations41LEARN ABOUT THESE METRICSArticle Views...
ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTThe Synthesis and Anticholinergic Activity of Ester Amide Derivatives 2-Substituted PiperidinesC. W. RYAN C. AINSWORTHCite this: J. Org. Chem. 1961, 26, 5, 1547–1550Publication Date (Print):May 1, 1961Publication History Published online1 May 2002Published inissue 1 1961https://pubs.acs.org/doi/10.1021/jo01064a058https://doi.org/10.1021/jo01064a058research-articleACS PublicationsRequest reuse permissionsArticle Views305Altmetric-Citations29LEARN...
A new technique for investigating kinetics in and transport between two liquid phases is described. The interface of known area established on the sinter a Stokes diffusion cell. Transport to controlled by across sinter. rate reaction can be sinter, at interface, slow transfer or homogeneous either phase. Each these cases described theoretically. Results are reported hydrolysis p-methylbenzyl chloride methyl nicotinate water/CCl4 water/isopropyl myristate. Reasonable agreement with theory...
Polycomb repressive complex 1 (PRC1) modifies chromatin through catalysis of histone H2A lysine 119 monoubiquitination (H2AK119ub1). RING1 and RNF2 interchangeably serve as the catalytic subunit within PRC1. Pathogenic missense variants in PRC1 core components reveal functions these proteins that are obscured knockout models. While Ring1a models remain healthy, microcephaly neuropsychiatric phenotypes associated with a pathogenic variant implicate unappreciated functions. Using an vitro...
ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTSynthesis of 5-(tert-alkyl)resorcinolsS. J. Dominianni, C. W. Ryan, and DeArmittCite this: Org. Chem. 1977, 42, 2, 344–346Publication Date (Print):January 1, 1977Publication History Published online1 May 2002Published inissue 1 January 1977https://pubs.acs.org/doi/10.1021/jo00422a037https://doi.org/10.1021/jo00422a037research-articleACS PublicationsRequest reuse permissionsArticle Views457Altmetric-Citations30LEARN ABOUT THESE METRICSArticle Views...
Every human somatic cell inherits a maternal and paternal genome, which work together to give rise cellular phenotypes. However, the allele-specific relationship between gene expression genome structure through cycle is largely unknown. By integrating haplotype-resolved genome-wide chromosome conformation capture, mature nascent mRNA, protein binding data from B lymphoblastoid line, we investigate this both globally locally. We introduce 4D Nucleome, enabling detailed analysis of mechanisms...
ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTChemistry of cephalosporin antibiotics. 22. Chemistry and biological activity 3-alkoxymethyl cephalosporinsJohn A. Webber, George William Huffman, R. E. Koehler, Charles Franklin Murphy, W. Ryan, Earle M. Van Heyningen, Robert T. VasileffCite this: J. Med. Chem. 1971, 14, 2, 113–116Publication Date (Print):February 1, 1971Publication History Published online1 May 2002Published inissue 1 February...
ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTSynthesis and Anticholinergic Activity of Ester Derivatives Substituted 3-PyrrolidinolsC. W. Ryan C. AinsworthCite this: J. Org. Chem. 1962, 27, 8, 2901–2905Publication Date (Print):August 1, 1962Publication History Published online1 May 2002Published inissue 1 August 1962https://pubs.acs.org/doi/10.1021/jo01055a043https://doi.org/10.1021/jo01055a043research-articleACS PublicationsRequest reuse permissionsArticle Views391Altmetric-Citations15LEARN...
This study reassessed the presence or absence of sex differences and investigated stability self-esteem as measured by Coopersmith's Self-esteem Inventory over 6 mo. for Grades 2 to 12. The subjects were 591 students, 296 male 295 female, enrolled in an urban central Maine school district. No found on any subscales total scale score either pretest posttests grade. Significant correlations, small moderate size, all grades two scales, general self self. results implications are discussed.
Improved syntheses of twotrans-3,4-dimethyl-4-(3-hydroxyphenyl)piperidine opioid antagonists from 1,3-dimethyl-4-piperidinone are described. The 1,3-dimethyl-4-arylpiperidinol 23 was selectively dehydrated in a two step process to the 1,3-dimethyl-4-aryl-1,2,3,6-tetrahydropyridine 26 by cis-thermal elimination corresponding alkyl carbonate derivative at 190 degrees C. In presence basic nitrogen, success found be critically dependent upon nature group, with Et, i-Bu, and i-Pr being preferred...
This study examined the role of career counselors in infusing systems thinking into occupational advising. The authors conducted a qualitative review and analysis selected literature on analyzed trends for adaptation to counseling practice. suggests that need infuse approaches professional practice, example, use language assists client exploring plans. also identified various new right‐brain directed (Pink, 2006; Shutt, 2008) sessions. Results implications are discussed.
Leadership approaches, or styles, practised by managers in free societies over the last 100 years have shifted from highly directive, authoritarian, to more non‐directive, participative. This study surveyed labour and management of a defence industry computer software company compare (n=35) technical employee (n=143) perceptions preferred style as measured Leader Behaviour Descriptive Questionnaire (LBDQ) Form XII. Subjects were asked rate their ideal leader response items on LBDQ....