A5014692092- Immune Cell Function and Interaction
- T-cell and B-cell Immunology
- Immunotherapy and Immune Responses
- Cancer Immunotherapy and Biomarkers
- Viral-associated cancers and disorders
- IL-33, ST2, and ILC Pathways
University of Zurich
2023-2024
University Hospital of Basel
2020-2021
University of Basel
2020-2021
University of Salzburg
2020
Analysis of CD4 + T cell heterogeneity in the lung uncovers a Bcl6-dependent subset that supports mucosal antibody production.
Epstein Barr virus (EBV) contributes to around 2% of all tumors worldwide. Simultaneously, more than 90% healthy human adults persistently carry EBV without clinical symptoms. In most carriers it is thought that virus-induced tumorigenesis prevented by cell-mediated immunity. Specifically, memory CD8+ T cells recognize EBV-infected during latent and lytic infection. Using a symptomatic primary infection model, similar infectious mononucleosis (IM), we found EBV-induced tissue-resident (TRMs)...
Humanized mouse models have been developed to study cell-mediated immune responses human pathogens in vivo. How immunocompetent T cells are selected a murine thymus such humanized mice remains poorly explored. To gain insights into this mechanism, we investigated the differentiation of compartments MHC class II-deficient immune-compromised (humanized Ab0 mice). We observed strong reduction CD4+ T-cell development but despite had no disadvantage during Epstein-Barr virus (EBV) infection....
Abstract Influenza is a severe and acute respiratory pathogen, significant cause for morbidity, particularly in young children the elderly. Following influenza infection, clonally expanded T cells take up permanent residence lung where they are poised to rapidly respond challenge infection. The non-circulating status of these tissue resident memory (TRM) makes them an attractive target vaccination. While many studies have characterized CD8 TRM cells, less known about heterogeneity protective...
Immune homeostasis in peripheral tissues is, to a large degree, maintained by the differentiation and action of regulatory T cells (Treg) specific for tissue Ags. Using novel mouse model, we have studied naive CD4+ into Foxp3+ Treg response cutaneous Ag (OVA). We found that expression OVA resulted fatal autoimmunity prevention generation. Inhibiting mTOR activity with rapamycin rescued generation cells. When varied level modulate TCR signaling, low concentrations promoted cells, whereas high...
Abstract Epstein Barr virus (EBV) contributes to around 2% of all tumors worldwide. Simultaneously, more than 90% healthy human adults persistently carry EBV without clinical symptoms. In most carriers it is thought that virus-induced tumorigenesis prevented by cell-mediated immunity. Specifically, memory CD8 + T cells recognize EBV-infected during latent and lytic infection. Using a symptomatic primary infection model, similar infectious mononucleosis (IM), we found induced tissue resident...