A5010844346- Innovative Microfluidic and Catalytic Techniques Innovation
- Microfluidic and Capillary Electrophoresis Applications
- Manufacturing Process and Optimization
- Oxidative Organic Chemistry Reactions
- Process Optimization and Integration
- Scientific Computing and Data Management
- Analytical Chemistry and Chromatography
Nawi Graz
2022-2024
University of Graz
2022-2024
Research Center Pharmaceutical Engineering (Austria)
2022-2024
Autonomous flow reactors are becoming increasingly utilized in the synthesis of organic compounds, yet complexity chemical reactions and analytical methods remains limited. The development a modular platform which uses rapid NMR FTIR measurements, combined with chemometric modeling, is presented for efficient timely analysis reaction outcomes. This tested four variable single-step (nucleophilic aromatic substitution), to determine most effective optimization methodology. self-optimization...
Abstract Flow processing offers many opportunities to optimize reactions in a rapid and automated manner, yet often requires relatively large quantities of input materials. To combat this, the use flexible slug flow reactor, equipped with two analytical instruments, for low‐volume optimization experiments are reported. A Buchwald–Hartwig amination toward drug olanzapine, 6 independent optimizable variables, is optimized using three different approaches: self‐optimization, design experiments,...
To automate and democratize model-based experimental design for flow chemistry applications, we report the development of open-source software, Optipus. Reaction models are built in an iterative automated fashion, rapid reaction development.
Flow processing offers many opportunities to optimize reactions in a rapid and automated manner, yet often requires relatively large quantities of input materials. To combat this, we report the use flexible droplet flow reactor, equipped with two analytical instruments, for low-volume optimization experiments. A Buchwald-Hartwig amination toward drug olanzapine, 6 independent optimizable variables, was optimized using three different approaches: self-optimization, design experiments kinetic...