A5076295562- Parasitic Diseases Research and Treatment
- Parasites and Host Interactions
- Helminth infection and control
- High Altitude and Hypoxia
- Dermatological diseases and infestations
- Potassium and Related Disorders
- Reformation and Early Modern Christianity
- Cardiovascular and Diving-Related Complications
- Neuroscience of respiration and sleep
- Heme Oxygenase-1 and Carbon Monoxide
- Thermal Regulation in Medicine
- HIV/AIDS Research and Interventions
- HIV Research and Treatment
- Energy and Environment Impacts
- Medical Imaging and Pathology Studies
- Pediatric Pain Management Techniques
- Plant Toxicity and Pharmacological Properties
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Asthma and respiratory diseases
- Bone and Joint Diseases
- Respiratory Support and Mechanisms
- Parathyroid Disorders and Treatments
- Air Quality and Health Impacts
- Parasite Biology and Host Interactions
- Inhalation and Respiratory Drug Delivery
University Hospital of Zurich
2024
Swiss Tropical and Public Health Institute
2013-2022
University of Basel
2018-2021
The Zurich Primary HIV Infection (ZPHI) study is a longitudinal cohort established in 2002, aiming to the clinical, epidemiological, and biological characteristics of primary infection. ZPHI enrolls individuals with documented HIV-1 At baseline thereafter, socio-demographic, laboratory data are systematically collected, regular blood sampling performed for biobanking. By end December 2022, 486 people were enrolled, which 353 still undergoing active follow-up. Of participants, 86% had an...
Although trichuriasis affects millions of children worldwide, recommended drugs lack efficacy and new treatment options are urgently needed. Ivermectin has promising potential to complement the anthelminthic armamentarium. A randomized placebo-controlled trial was conducted in rural Côte d'Ivoire provide evidence on safety ascending oral ivermectin dosages preschool-aged (PSAC) school-aged (SAC) infected with Trichuris trichiura. The primary outcome cure rate (CR) for T. trichiura infection,...
Yearly, millions of children are treated globally with ivermectin mainly for neglected tropical diseases. Anatomical, physiological and biochemical differences between adults may result in changes pharmacokinetics. However, paediatric pharmacokinetic data lacking.In the framework a randomized controlled dose-finding trial rural Côte d'Ivoire, Trichuris trichiura-infected pre-school-aged (PSAC, 2-5 years) school-aged (SAC, 6-12 were assigned to 100 or 200 μg/kg 200, 400 600 ivermectin,...
Abstract Background Trichuriasis represents a major public health problem in the developing world and is regarded as neglected disease. Albendazole mebendazole, two drugs of choice against trichuriasis display only moderate cure rates, hence alternative are needed. To identify candidate compounds, vitro drug sensitivity testing currently relies on adult Trichuris muris motility assay. The objective present study was to develop simple cost-effective assay using first-stage larvae (L1)....
Chronic obstructive pulmonary disease is a global problem and available data from sub-Saharan Africa very limited.A cross-sectional facility-based pilot study among patients visitors to an urban rural primary healthcare facility was conducted in coastal Tanzania. The outcome the prevalence of chronic airflow obstruction.The final analysis included 598 participants with valid post-bronchodilator spirometry. Applying ATS/ERS spirometric criteria, obstruction found n = 24 (4%, CI95 2.7-5.9) 30...
Abstract Background The burden of chronic respiratory symptoms and functional limitations is underestimated in Africa. Few data are available on carbon monoxide (CO) poisoning sub-Saharan Africa existing derived from CO ambient air, but not biomarkers the blood. Methods Data Tanzanian Lung Health study, a cross-sectional study lung health among outpatients visitors to an urban as well rural hospital Tanzania, was analyzed describe limitations. Saturation peripheral blood with (SpCO) measured...