A5046536980- Membrane Separation and Gas Transport
- Covalent Organic Framework Applications
- Synthesis and properties of polymers
- Metal-Organic Frameworks: Synthesis and Applications
- Membrane Separation Technologies
- Fuel Cells and Related Materials
- Electrospun Nanofibers in Biomedical Applications
- Carbon Dioxide Capture Technologies
- Nanoparticle-Based Drug Delivery
- Muon and positron interactions and applications
- Zeolite Catalysis and Synthesis
- Simulation-Based Education in Healthcare
- Phagocytosis and Immune Regulation
- Injection Molding Process and Properties
- Advanced biosensing and bioanalysis techniques
- Dielectric materials and actuators
- Graphene research and applications
- Web Data Mining and Analysis
- Retinoids in leukemia and cellular processes
- Hydrogels: synthesis, properties, applications
- Radioactive element chemistry and processing
- Monoclonal and Polyclonal Antibodies Research
- Personal Information Management and User Behavior
- HER2/EGFR in Cancer Research
- Gas Dynamics and Kinetic Theory
Massachusetts Institute of Technology
2019-2024
University of California, San Diego
2023
University of Connecticut
2021
Vanderbilt University
2016
University at Buffalo, State University of New York
2015
Instytut Farmaceutyczny
2013
Albany College of Pharmacy and Health Sciences
2013
University of California, Irvine Medical Center
2012
Shanxi University
2011
Albany Research Institute
2011
Mixed-matrix membranes (MMMs) formed by dispersing metal–organic framework (MOF) particles in polymers have attracted significant attention because these composite systems can potentially surpass the separation performance of pure alone. However, improvements are often unrealized poor interfacial compatibility between MOF and polymer, which results defects. From a practical perspective, strategies needed to address defects so that MMMs be deployed real-world processes. fundamental reliably...
Polymer membranes with ultrahigh CO2 permeabilities and high selectivities are needed to address some of the critical separation challenges related energy environment, especially in natural gas purification postcombustion carbon capture. However, very few solution-processable, linear polymers known today that access these types characteristics, all structures achieve their performance through design rigid backbone chemistries concomitantly increase chain stiffness interchain spacing, thereby...
An optimized acid hydrolysis method was developed to yield carboxylic acid-functionalized PIM-1 (PIM-COOH) with >89% conversion in 48 h using a postpolymerization reaction of PIM-1. Physical characterization and PIM-COOH revealed that the average size free volume elements decreased relative Compared PIM-1, showed significant increase CO2- H2-based selectivities corresponding decrease permeabilities sorption capacities for all gases considered. The dual-mode model, time-lag method,...
Unmodified or as a poly[lactide-co-glycolide] nanoparticle, tetraiodothyroacetic acid (tetrac) acts at the integrin αvβ3 receptor on human cancer cells to inhibit tumor cell proliferation and xenograft growth. To study in vitro pharmacodynamics of tetrac formulations absence conjunction with other chemotherapeutic agents, we developed perfusion bellows culture system. Cells were grown polymer flakes exposed various concentrations tetrac, nano-tetrac, resveratrol, cetuximab, combination for...
Thyroid hormone induces tumor cell and blood vessel proliferation via a surface receptor on heterodimeric integrin αvβ3. We investigated the role of thyroid hormone-induced internalization nuclear αv monomer. Physiological concentration thyroxine (free T4, 10–10 M), but not 3,5,3'-triiodo-L-thyronine (T3), induced cellular translocation monomer in human non-small-cell lung cancer (H522) ovarian carcinoma (OVCAR-3) cells. T4 did complex with during its internalization. The was phosphorylated...
In this work, we demonstrate controlled drug delivery from low-temperature-sensitive liposomes (LTSLs) mediated by photothermal heating multibranched gold nanoantennas (MGNs) in triple-negative breast cancer (TNBC) cells vitro. The unique geometry of MGNs enables the generation mild hyperthermia (∼42 °C) converting near-infrared light to heat and effectively delivering doxorubicin (DOX) LTSLs cells. We confirmed cellular uptake using both fluorescence confocal Z-stack imaging transmission...
Abstract Gas‐separation polymer membranes display a characteristic permeability–selectivity trade‐off that has limited their industrial use. The most comprehensive approach to improving performance is devise strategies simultaneously increase fractional free volume, narrow volume distribution, and enhance sorption selectivity, but generalizable methods for such approaches are exceedingly rare. Here, we present an in situ crosslinking solid‐state deprotection method access previously...
No AccessJournal of UrologyAdult Urology1 Apr 2012High Fidelity Simulation Based Team Training in Urology: A Preliminary Interdisciplinary Study Technical and Nontechnical Skills Laparoscopic Complications Management Jason Y. Lee, Phillip Mucksavage, Cecilia Canales, Elspeth M. McDougall, Sharon Lin LeeJason Lee Division Urology, St. Michael's Hospital, Toronto, Ontario, Canada , MucksavagePhillip Mucksavage Department University California Irvine Medical Center, Orange, CanalesCecilia...
Ceramide is a member of the sphingolipid family bioactive molecules demonstrated to have profound, diverse biological activities. potential chemotherapeutic agent via induction apoptosis. Exposure ceramide activates extracellular-signal-regulated kinases (ERK)1/2- and p38 kinase-dependent apoptosis in human ovarian cancer OVCAR-3 cells, concomitant with an increase expression COX-2 p53 phosphorylation. Blockade cyclooxygenase-2 (COX-2) activity by siRNA or NS398 correspondingly inhibited...
Partially fluorinated polymers often exhibit exceptional membrane-based separation performance for a variety of gas pairs. While many transport studies focus on the incorporation aliphatic fluorine groups (e.g., −CF3) polymer backbone, few have systematically investigated structure–property relationships aromatic groups. Here, effect and solid-state morphology is compared structural analogues 6FDA-based polyimides that contain either hydrogen or functional diamine monomer. Both displayed...
Bottlebrush polymers with flexible backbones and rigid side chains have shown ultrahigh CO2 permeability plasticization resistance for membrane-based gas separations. To date, this class of has only been studied polydisperse chains. Herein, we report transport properties a methoxy (OMe) functionalized polymer synthesized via ring-opening metathesis polymerization (ROMP) uniform side-chain lengths ranging from n = 2 to 5 repeat units elucidate the role both length dispersity on resistance. As...
Nonaqueous fluidic transport and ion solvation properties under nanoscale confinement are poorly understood, especially in conduction for energy storage conversion systems. Herein, metal-organic frameworks (MOFs) aprotic electrolytes studied as a robust platform molecular-level insights into electrolyte behaviors confined spaces. By employing computer simulations, along with spectroscopic electrochemical measurements, we demonstrate several phenomena that deviate from the bulk, including...
Hydrocarbon and perfluorinated polymers display distinct thermodynamic partitioning characteristics. These differences enable perfluoropolymers to outperform hydrocarbon for many membrane-based gas separations, but the mechanism in which fluorine affects sorption selectivity is still not well understood. To bridge existing gap our fundamental understanding of polymers, this study investigates across a range temperatures, pressures, species four polyimides containing varying content. Observed...
Polyvinyl alcohol (PVA)/laponite (LP) nanocomposite coatings were fabricated via a facile one-step coassembly process. The formed nanocoatings contain high concentration of LP nanosheets, which can be well aligned along the substrate surface during Due to highly orientated structure, flexible exhibit ultra-high transparency and superior mechanical properties, also act as excellent gas barriers. Such exceptional candidates for variety applications, such food packaging.
Antigen presenting cell (APC) gene delivery is a promising avenue for modulating immunological outcomes toward desired state. Recently, our group developed methodology to elicit targeted and elevated levels of APC-mediated delivery. During these initial studies, we observed APC-specific structure-function relationships with the vectors used during that differ from current non-APC lines, thus, emphasizing need re-evaluate vector-associated parameters in context APC transfer. Thus, describe...
Abstract Gas‐separation polymer membranes display a characteristic permeability–selectivity trade‐off that has limited their industrial use. The most comprehensive approach to improving performance is devise strategies simultaneously increase fractional free volume, narrow volume distribution, and enhance sorption selectivity, but generalizable methods for such approaches are exceedingly rare. Here, we present an in situ crosslinking solid‐state deprotection method access previously...
Abstract The optimum one-step method for preparing comb-like surfactants with poly(styrene-co-maleic anhydride) (SMA) as backbone was investigated to achieve a commercial way manufacture. side chain molecule introduced into reaction system while the radical copolymerization of styrene (St) and maleic anhydride (MA) in anhydrous inhibitor-free tetrahydrofuran (THF) finished. precipitation purification process SMA traditional grafting-onto route passed over. A series various chain,...
This study details the enhancement of CO2 selectivity in ring-opening metathesis polymerization (ROMP) polymers that contain nitrile moieties and micropore-generating ladder side chains. A material, CN-ROMP homopolymer, with nitriles chains was originally targeted synthesized; however, its low molecular weight backbone rigidity precluded film formation. As a result, an alternative method pursued wherein copolymers were synthesized using norbornene (N) (NN). Herein, we report investigation...