Cancer-associated fibroblasts, which are densely found in tumor tissue, express high levels of fibroblast activation protein (FAP), and FAP inhibitors (FAPIs) labeled with radionuclides can be used the diagnosis treatment cancer. In this study, role 68Ga-DOTA-FAPI-04 PET/CT imaging primary, metastatic, recurrent cancers was investigated.A total 42 patients (16 females, 26 males; mean age, 58.5 years; range, 31-84 years) 22 different types malignant diseases were included study. performed 1...

Growing research suggests that digital flashcards may facilitate students' technical vocabulary learning efforts. The primary purpose of this quasi-experimental study was to compare the effect (DFs) and wordlists on as well explore perceptions regarding use DFs. Using convenience sampling method, conducted with a total 57 undergraduate pharmacy students. Data were collected using pre-treatment survey, two tests, post-treatment survey. results indicated (1) students learned more through DFs;...

We investigated the level of sympathetic hyperactivity in response to stress exposure an acute myocardial infarction (AMI) model and contribution oxidative nitrosative damage this phenomenon. Stress was induced by 20-day administration different emotional factors: daylight/darkness exposure, overcrowding, isolation, new hierarchy, tilting cage restriction water or food. AMI surgically. Heart rate (HR) heart variability (HRV) measurements were done before after AMI. Oxidant parameters...

Background In the present study, nitric oxide (NO) was investigated to see if it mediated effects of nebivolol on apoptosis in rat myocardial infarction (MI) model. Methods and Results Rats were divided into 3 groups: sham operated (sham-control), MI-induced (MI-control) treated (MI-nebivolol). The initial dose administrated intravenously (iv) within 10 min post-MI reperfusion continued orally for 28 days. NO assessed either early (2nd day) or sub-acute (28th period MI by histologic,...

Epilepsy is one of the most common chronic neurological disorders with a high prevalence. Epileptic people and their family members suffer more from social stigma than disorder itself. Among various complex reasons knowledge awareness about epilepsy are two important factors underlying discriminatory attitudes towards epileptic people. Community pharmacists play major role in care these patients. In this study we mainly aimed to gain insights into (AKA) both healthy individuals an urban...

Aging is an important risk factor for erectile dysfunction (ED). Both calorie restriction (CR) and physical exercise (PE) have been established as a non-medical method the improvement of detrimental changes in aging. It well documented that both CR PE influence on sympathetic parasympathetic systems; however, there are few studies non-adrenergic non-cholinergic pathways. This study aims to investigate NO-mediated mechanisms corpus cavernosum aged rats.3 15 month-old rats were divided into...

Ventricular remodeling (VR) which develops after myocardial infarction (MI) plays an important role in progressive left ventricular dysfunction. We aimed to investigate the of nebivolol treatment on VR a MI rat ischemia-reperfusion model.Rats were divided into 3 groups 12 each: sham operated (sham-control), MI-induced (MI-control) and treated (MI-nebivolol). Left (LV) diameters, volumes, diastolic filling parameters evaluated by echocardiography. On 28th day, recording systemic LV pressures...

Amaç: Çoklu ilaç kullanımına bağlı olarak gelişen ilaç-ilaç etkileşimleri (DDI) advers reaksiyonlarının en önemli nedenidir.İlaç hatalarından bir tanesi sayılan DDI önlenebilir.Sağlık profesyonellerinin tıbbi ve pratik bilgilerinin yanında kullanacakları entegre bilgisayarlı etkileşimi kontrol sistemleri, tek başlarına yeterli olmamakla beraber olası etkileşimlerin azaltılması için sağlık personeline yardımcı olabilir.Bu çalışmada ayaktan pediatri hastalarına reçete edilen klaritromisin ile...

Like in other industries, the competition among companies pharma industry is high. Therefore pharmaceutical have to design their strategies order achieve competitive advantage. Brand loyalty a powerful tool development of brands. Physicians play major role selection drugs consume and can also be considered as consumer. This descriptive study examines factors that influence physicians’ choices medication for patients. Data was collected using survey administered specialists trainees from...

Despite several proposed mechanisms for the pathophysiology of cardiorenal syndrome (CRS), exact mechanism remains unclear. Nitrosative stress has been argued as a key recently. Nebivolol is beta-blocker with nitric oxide (NO)-releasing effect. In present study, NO-mediated effects two different treatment regimes nebivolol in CRS were studied.Rats divided into: sham-operated (sham-control), myocardial infarction (MI)-induced, (MI-control) early nebivolol-treated (MI-neb1) and late (Mı-neb2)...

Radiolabeled bisphosphonates have found wide clinical use in nuclear medicine for palliative therapy of bone metastases. 177Lu-EDTMP was used to relieve metastatic pain patients with breast or prostate cancer. The therapeutic efficacy at 1-, 3-, 6-, and 8-weeks post-therapy evaluated using Standard Pain Scoring Assessment Criteria. In addition, toxicity terms hematological parameters the Common Terminology Criteria Adverse Events V4.0.A fully automated synthesis achieved this study high...

New series of [(2-chloroethyl)ureido] benzoic acids (compounds 3-8) and nitric oxide releasing derivatives acid esters 9-14) were synthesized as potential anti-cancer agents. These compounds screened for their anti-proliferative activities on A549 (human lung carcinoma) cells cytotoxic effects L929 (mouse fibroblast) cells. The 3-8 exhibited mild (cell viability from 100% to 85% -- 90% only) whereas they had very little towards carcinoma On the other hand, 10, 11, 13 some growth inhibition...

A new series of 6-acyl-3-alkyl-5-methyl-2(3H)-benzoxazolones have been obtained starting from 5-methyl-2(3H)-benzoxazolone. All the compounds characterized by IR, ¹H-NMR and mass spectroscopy. The were screened for analgesic anti-inflammatory activities ulcerogenic effect. <i>in vitro</i> antioxidant capacity synthesized tested nitric oxide radical scavenging assay. Most showed antiinflammatory activity. Among them,...

With its suitable nuclear decay characteristics and large-scale production feasibility with adequate specific activity, 177Lu is regarded as an excellent radionuclide for developing bone pain palliation agent. Ethylenediamine-tetramethylene phosphonic acid (EDTMP) a preferred carrier molecule radiolanthanides, such 177Lu. The present paper describes the synthesis of EDTMP development ready-to-use kit preparation 177Lu-EDTMP quality control in accordance safety criteria required medicinal...

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at glance that was extracted from about 200 leading journals. To access of an article which published elsewhere, please select “Full Text” option. The original trackable via the “References”

Background and objective: Heart failure (HF) is a common complication of cardiovascular disease, which leads to functional cardiac abnormalities. Beta-blockers are commonly used reduce mortality in HF patients; however, they associated with an increased risk erectile dysfunction (ED). Nebivolol third-generation beta-blocker also having Nitric oxide (NO) releasing effect. NO plays key role penile erection. The aim this study was investigate the NO-mediated effects nebivolol on ED HF. Material...