For many hematological malignancies (HMs) survival among older patients is compromised. We want to test the most up-to-date age-group-specific differences in five malignancies, Hodgkin lymphoma (HL), multiple myeloma (MM), chronic lymphocytic leukemia (CLL), acute myeloid (AML) and myeloproliferative diseases (MPD) Sweden (SE) compared these Denmark, Finland Norway. analysis we apply a recently published metric for comparing visualizing relative using data from NORDCAN database between 1972...

Familial clustering of lung cancer (LC) is related to shared smoking habits but the contribution other potential factors such as sex or histology not well known, and these are subjects present study in Sweden. Family relationships (from Multigeneration register) diagnosed cancers Cancer registry) were obtained from national registers 1961 2021. The overall familial risk for LC was constant 1990s male decreased while female doubled at same time when incidence doubled. mother-daughter pairs...

Cancers of the head and neck (HN) are heterogeneous tumors with incidence rates varying globally. In Northern Europe oral oropharyngeal cancers most common individual types. Survival for HN varies by tumor type but them survival trends not well known over extended periods time.

Background: Chronic lymphocytic leukemia (CLL) is a common hematological malignancy with highly variable clinical presentation. Many patients never require any treatment but for the others, chemotherapy, immunochemotherapy, and newer targeted therapies have changed landscape. Diagnostic age influences applied treatment, we thus wanted to analyze age-specific survival trends through 50 years up 2020s. Methods: We used 1- 5-year relative from NORDCAN database, data Denmark (DK), Finland (FI),...

Before the course of Alzheimer’s disease fully manifests itself and largely impairs a patient’s cognitive abilities, its progression has already lasted for considerable time without being noticed. In this project, we mapped development spatial orientation impairment in an active place avoidance task—a highly sensitive test mild hippocampal damage. We tested vision, anxiety performance at four age levels 4, 6, 9, 12 months across male female TgF-344 AD rats carrying human genes presenilin-1...

Abstract Backround We wanted to characterize conditional survival in prostate cancer (PC) Sweden around and after 2005 when the vast increase incidence due opportunistic testing for specific antigen (PSA) culminated. hypothesize that analyzing data during time period may help interpret trends. focus on stage‐specific analysis using order define periods deaths most commonly occurred. Methods Data PC patients were obtained from Swedish registry of 1‐, 2.5‐ 5‐year relative between years 2004...

Diagnostic age is an important determinant of cancer survival but the methods generally used to analyze age-group-specific are not developed for ready visualization differences. We aim at developing a novel metric comparing and visualizing data over different cancers, sexes, periods countries. The describes mean absolute deviation between age-groups. can be in two variations, one showing variation its 95% confidence intervals other highlighting individually each age-groups distinguishing...

Abstract Esophageal cancer (EC) and gastric (GC) are fatal cancers with a relatively late age of onset. Age is negative risk factor for survival in many our aim was to analyze age‐specific EC GC using the recently updated NORDCAN database. data originate from Danish, Finnish, Norwegian, Swedish nationwide registries covering years 1972 through 2021 inviting comparison 50‐year trends between countries. Relative 1‐ 5‐year 5/1‐year conditional (i.e., those who were alive Year 1 survive...

Thyroid cancer (TC) is diagnosed in several histological types which differ their clinical characteristics and survival. We aim to describe how they influence TC survival Sweden.

Abstract Background Survival in breast cancer (BC) has developed favorably but late recurrences are still a problem. Methods We model survival data from the NORDCAN database and analyze 1‐, 5‐, 10‐year relative 5/1‐ 10/5‐year conditional BC Denmark (DK), Finland (FI), Norway (NO), Sweden (SE) between 1971 2020. Conditional measures those who had survived year 1 to reach 5 (5/1), or 10 (10/5). Results Almost all metrics were best for SE countries improved course of time approaching levels...

Viral hepatitis, which appears most frequently at birth or during childhood, is a disease whose transmission routes include tears, bile, sexual fluids, sweat, milk, urine, feces, and saliva. The aim of the present study was to analyze specificity immunochromatographic ELISA diagnostic tests for hepatitis B surface antigen compare them with PCR testing.The sample made up 140 men 60 women referred Urmia Medical University hospital undergo testing HBV diagnosis. test performed using Pioneer...

Abstract The hippocampus plays a crucial role in the formation and retrieval of spatial memory across mammals episodic humans. Episodic memories can be retrieved irrespective subject’s awake behavioral state independently its actual context. However, nature hippocampal network activity during such out-context has not been described so far. Theoretically, context-independent suggests shift representations from coding current context to remembered environment. In this study we show rats that...

The incidence of prostate cancer (PC) increased vastly as a result prostate-specific antigen (PSA) testing. Survival in PC improved the PSA-testing era, but changes clinical presentation have hampered interpretation underlying causes.We analyzed survival trends using data from NORDCAN database for Denmark (DK), Finland (FI), Norway (NO) and Sweden (SE) by analyzing 1-, 5- 10-year relative conditional over course 50 years (1971-2020).In pre-PSA FI SE marginally NO not DK. PSA testing began...

Abstract Retrieval of stored network activity pattern has been shown as a competitive transition from one attractor state to another, orchestrated by local theta oscillation. However, the fine nature this process that is considered substrate memory recall not clear. We found hippocampal characterized hyperactivity in CA3 place cell population, associated with an “overexpression” retrieved pattern. The overexpression was based on recruitment cells same (recalled) spatial representation low...

Colorectal cancer is currently the third leading cause of cancer-related deaths and recently, alternative splicing has risen as its important regulator potential treatment target. In present study, we analyzed gene expression MBNL family regulators in various stages colorectal development, together with MBNL-target events FOXP1 EPB41L3 genes tumor-related CD44 variants.Samples tumor tissue non-malignant mucosa from 108 patients were collected. After RNA isolation reverse transcription,...

Background: Despite treatment having improved through intensive surgical procedures and chemotherapy—and more recently, targeted therapies—ovarian cancer is the most fatal female cancer. As such, we wanted to analyze age-specific survival trends for ovarian in Denmark, Finland, Norway Sweden over past 50 years, with a special aim of comparing development between age groups. Methods: We modelled data from NORDCAN database 1-, 5- conditional 5/1-year relative (between years 1 5) 1972 2021....

Background: Lung cancer (LC) is often diagnosed at a late stage in relatively old persons whose survival may be compromised because of limited treatment. Our aim was to carry out an age-specific study on LC Denmark (DK), Finland (FI), Norway (NO) and Sweden (SE) through half century (1972-2021). Nordic data were compared with the US Surveillance, Epidemiology End Results (SEER) database Methods: Relative 1- 5-year extracted from NORDCAN subjected modelling by generalized additive models for...

La hepatitis viral aparece más frecuentemente al nacer o durante la infancia y es una enfermedad cuyas vías de transmisión incluyen lágrimas, bilis, fluidos sexuales, sudor, leche, orina, heces saliva. El objetivo del presente estudio fue analizar especificidad inmunocromatografía prueba ELISA para el antígeno superficie B compararlas con PCR. muestra estuvo compuesta por 140 hombres 60 mujeres referidos hospital Escuela Medicina Universidad Urmia diagnóstico VHB medio realizada kit Pioneer...

Abstract Hippocampus plays a crucial role in formation and retrieval of spatial memory across mammals episodic humans. Episodic as well memories can be retrieved irrespectively subject’s awake behavioral state independently its actual context. The nature hippocampal network activity during such out-context has not been described so far, though. Theoretically, context-independent suggests shift from the representations coding actual- to remembered In this study we show rats that CA3 neuronal...