A5003482741- Sarcoma Diagnosis and Treatment
- Bone Tumor Diagnosis and Treatments
- Musculoskeletal synovial abnormalities and treatments
- Reconstructive Surgery and Microvascular Techniques
- Oral and Maxillofacial Pathology
- Bone fractures and treatments
- Orthopedic Surgery and Rehabilitation
- Soft tissue tumor case studies
- Medical and Biological Sciences
- Orthopaedic implants and arthroplasty
- Musculoskeletal Disorders and Rehabilitation
- Cancer Diagnosis and Treatment
- Advanced Radiotherapy Techniques
- Anatomy and Medical Technology
- Vascular Tumors and Angiosarcomas
- Bone health and osteoporosis research
- COVID-19 and healthcare impacts
- Inflammatory Myopathies and Dermatomyositis
- Orthopedic Infections and Treatments
- Bone health and treatments
- Diversity and Career in Medicine
- Forensic Anthropology and Bioarchaeology Studies
- 3D Printing in Biomedical Research
- Neuroendocrine Tumor Research Advances
- Management of metastatic bone disease
The Maria Sklodowska-Curie National Research Institute of Oncology
2018-2024
University College London
2017-2021
Royal National Orthopaedic Hospital
2017-2021
Royal National Orthopaedic Hospital NHS Trust
2017-2021
Clinical Orthopaedics and Related Research
2020
University of Pennsylvania
2020
Centrum Onkologii
2018
Medical University of Warsaw
2016
Inflammatory myofibroblastic tumor (IMT) is a rare neoplasm with intermediate malignancy characterized by propensity for recurrence but low metastatic rate.Diagnostic challenges arise from the diverse pathological presentation, variable symptomatology, and lack of different imaging features.However, IMT identified fusion anaplastic lymphoma kinase (ALK) gene, which present in approximately 70% cases, various partners, including ran-binding protein 2 (RANBP2), allows confirmation...
Abstract Purpose: Tenosynovial giant cell tumor (TGCT) is a locally aggressive neoplasm caused by dysregulation of the colony-stimulating factor 1 (CSF1) gene and overexpression CSF1 ligand. Surgery standard care for most patients, but there are limited treatment options patients with TGCT not amenable to surgery. This study evaluates vimseltinib, an investigational, oral, switch-control tyrosine kinase inhibitor designed selectively potently inhibit receptor. Patients Methods:...
Osteosarcoma is the most common primary malignant bone tumor in adults and usually located long bones. Standard treatment consists of perioperative chemotherapy radical surgical resection. Limb-sparing surgery using a variety reconstructive techniques remains gold standard.In our study, we retrospectively analyzed 90 adult patients operated at institution between 2000 2017 for extremity osteosarcoma that underwent limb-sparing reconstruction with megaprosthesis. Sixty-one resection distal...
To validate the reliability and implementation of an objective diagnostic method for giant cell tumour bone (GCTB). H3-3A gene mutation testing was performed using two different methods, Sanger sequencing immunohistochemical (IHC) assays. A total 214 patients, including 120 with GCTB 94 other cell-rich lesions, participated in study. IHC anti-histone H3.3 G34W G34V antibodies were on formalin-fixed, paraffin-embedded tissues, which previously decalcified EDTA if needed. The sensitivity...
Solitary fibrous tumors (SFT) are rare mesenchymal neoplasms that account for less than 2% of all soft tissue masses. In the latest WHO 2020 Classification Soft Tissue Tumors, extrameningeal SFT was listed as intermediate (rarely metastasizing) or malignant neoplasms. Due to lack characteristic clinical features, their diagnosis and treatment remain challenging. The pathogenesis is often associated with presence fusions NAB2-STAT6 gene on 12q13 chromosome. Cytoplasmic CD34 positive staining...
1 BACKGROUND: COVID-19 pandemic had a major impact on the healthcare system globally. This work aims to evaluate local treatment in bone sarcoma treated single, high-throughput institution. 2 METHODS: We have analyzed outcomes (i.e., possibility of limb sparing surgery) all patients between January 2016 and November 2022 main reference center Poland. Patients 2016-2019 period were regarded as "pre-pandemic" group, 2020-2022 - "pandemic". Mann-Whitney U Chi-square tests used statistical...
From the Column Editor, Although Dr. San Baw developed and designed his own ivory hip arthroplasty prosthesis, he was not first to use for this procedure. Prof. Themistocles Glück used an ball socket joint replace femoral head of a patient in Germany 1891—its earliest known use. In 1927, Ernest W. Hey Groves replaced ankylosed with stemmed replacement—a design similar contemporary resurfacing prostheses [1, 3, 7]. But unlike Groves, team continued materials throughout their careers. fact,...
<div>AbstractPurpose:<p>Tenosynovial giant cell tumor (TGCT) is a locally aggressive neoplasm caused by dysregulation of the <i>colony</i>-<i>stimulating factor 1</i> (<i>CSF1</i>) gene and overexpression CSF1 ligand. Surgery standard care for most patients, but there are limited treatment options patients with TGCT not amenable to surgery. This study evaluates vimseltinib, an investigational, oral, switch-control tyrosine kinase inhibitor...
<div>AbstractPurpose:<p>Tenosynovial giant cell tumor (TGCT) is a locally aggressive neoplasm caused by dysregulation of the <i>colony</i>-<i>stimulating factor 1</i> (<i>CSF1</i>) gene and overexpression CSF1 ligand. Surgery standard care for most patients, but there are limited treatment options patients with TGCT not amenable to surgery. This study evaluates vimseltinib, an investigational, oral, switch-control tyrosine kinase inhibitor...
<p>Supplement to CSF1R Inhibition in Patients With Advanced Solid Tumors or Tenosynovial Giant Cell Tumor: A Phase 1 Study of Vimseltinib. Contains supplementary methods, tables, and figures.</p>
<p>Supplement to CSF1R Inhibition in Patients With Advanced Solid Tumors or Tenosynovial Giant Cell Tumor: A Phase 1 Study of Vimseltinib. Contains supplementary methods, tables, and figures.</p>
Background. Delay in the diagnosis and treatment of bone tumors continues to be a common problem. Prolonged can significantly reduce chances successful disease. Accordingly, aim this study was assess delay primary tumors, identify most symptoms analyze course diagnostic therapeutic path.Material methods. Thirty-two (K=18; M=14) patients treated surgically for were included retrospective study. Patient records analyzed. defined as time from onset initial referral an orthopedic oncology...
Primary malignant bone tumours, or sarcomas, are rare and represent a major diagnostic therapeutic challenge. According to the EUROCARE database, they do not exceed 0.2% of all malignancies. American Cancer Society, over 40% primary tumours in adults chondrosarcomas followed by osteosarcoma (28%), chordoma (10%) Ewing sarcoma (8%), histiocytic sarcoma/fibrosarcoma (4%), remaining percentages is distributed among several types tumours. In children adolescents ( < 20 years), accounts for 56%,...
Background.The problem of atypical fractures, such as subtrochanteric or diaphyseal femoral associated with long-term treatment bisphosphonates (BPs) has recently been given increasingly more attention.These fractures develop stress and are characterised by cortical thickening a transverse slightly oblique fracture line.The use documented to reduce the risk osteo porotic fractures.However, an increasing number papers verify safety benefits administration these drugs over than 3-5...