A5090251579- Air Quality and Health Impacts
- Occupational exposure and asthma
- Climate Change and Health Impacts
- Occupational and environmental lung diseases
- Immune cells in cancer
- Nanoparticles: synthesis and applications
- 3D Printing in Biomedical Research
- Cancer, Stress, Anesthesia, and Immune Response
- Biomarkers in Disease Mechanisms
- Inflammasome and immune disorders
- Cell Image Analysis Techniques
- Inflammatory mediators and NSAID effects
- Heme Oxygenase-1 and Carbon Monoxide
- Peptidase Inhibition and Analysis
- Tryptophan and brain disorders
- Trauma and Emergency Care Studies
- Cancer Research and Treatments
- Image Processing Techniques and Applications
- Protease and Inhibitor Mechanisms
- Tea Polyphenols and Effects
- Animal testing and alternatives
- NF-κB Signaling Pathways
- Additive Manufacturing and 3D Printing Technologies
- Histone Deacetylase Inhibitors Research
- Microplastics and Plastic Pollution
Örebro University
2017-2024
Karlstad University
2014-2022
Due to their exceptional properties and cost effectiveness, polyamides or nylons have emerged as widely used materials, revolutionizing diverse industries, including industrial 3D printing additive manufacturing (AM). Powder-based AM technologies employ tonnes of polyamide microplastics produce complex components every year. However, the lack comprehensive toxicity assessment particulate polyamide-associated chemicals, especially in light global crisis, calls for urgent action. This study...
Malignant tumors, including breast cancers, are frequently infiltrated with innate immune cells and tumor-associated macrophages (TAMs) represent the major inflammatory component in stroma of many tumors. In this study, we examined immunoreactivity macrophage markers CD68 CD163 as well hormone receptors estrogen receptor α (ERα), progesterone (PR), β1 (ERβ1), human epidermal growth factor 2 (HER-2), matrix metalloproteinase 9 (MMP‑9), urokinase-type plasminogen activator (uPAR)...
Additive manufacturing (AM) or industrial 3D printing uses cutting-edge technologies and materials to produce a variety of complex products. However, the effects unintentionally emitted AM (nano)particles (AMPs) on human cells following inhalation, require further investigations. The physicochemical characterization AMPs, extracted from filter Laser Powder Bed Fusion (L-PBF) printer iron-based materials, disclosed their complexity, in terms size, shape, chemistry. Cell Painting, high-content...
Abstract Background The inflammatory responses are central components of diseases associated with particulate matter (PM) exposure, including systemic such as cardiovascular (CVDs). aim this study was to determine if exposure PM, respirable dust or quartz in the iron foundry environment mediates responses, focusing on NLRP3 inflammasome and novel established markers CVDs. Methods dust, metals were determined 40 workers at two separate occasions per worker. In addition, blood samples...
To study the association between inhalation of particulate matter or quartz in Swedish iron foundries and effects on NLRP3 inflammasome activation.Particle exposure measurements were performed during an eight-hour work day for 85 foundry workers at three foundries. Personal sampling was used measurement respirable dust stationary to obtain inhalable PM10. The markers, interleukin- (IL-) 1β IL-18, inhibitors IL-1 receptor antagonist (IL-1Ra) IL-18 binding protein (IL-18BP) measured plasma....
To study the relationship between inhalation of airborne particles and quartz in Swedish iron foundries markers inflammation coagulation blood. Personal sampling respirable dust was performed for 85 subjects three foundries. Stationary measurements were used to concentrations quartz, inhalable total dust, PM10 PM2.5, as well particle surface area number concentrations. Markers inflammation, namely interleukins (IL-1β, IL-6, IL-8, IL-10 IL-12), C-reactive protein, serum amyloid A (SAA)...
Purpose To study the relationship between respirable dust, quartz and chemical binders in Swedish iron foundries respiratory symptoms, lung function (as forced expiratory volume FEV1 vital capacity FVC), fraction of exhaled nitric oxide (FENO) levels club cell secretory protein 16 (CC16) CRP. Methods Personal sampling dust was performed for 85 subjects three foundries. Full shift examination were on second or third day a working week after work free weekend, with additional fourth fifth day....
Resistance of tumor cells to chemotherapy, such as 5‑fluorouracil (5‑FU), is an obstacle for successful treatment cancer. As a follow‑up previous study we have investigated the effect conditioned media (CM) from macrophages M1 or M2 phenotypes on 5‑FU cytotoxicity colon cancer cell lines HT‑29 and CACO‑2. cells, but not CACO‑2 having been treated with combination CM recovered their growth much larger extent compared alone when further cultured 7 days in fresh media. HT‑29, induced cycle...
Objective: To study the relationship between inhalable dust and cobalt, respiratory symptoms, lung function, exhaled nitric oxide in expired air, CC16 Swedish hard metal industry. Methods: Personal sampling of medical examination including blood was performed for 72 workers. Exposure-response relationships were determined using logistic, linear, mixed-model analysis. Results: The average cobalt concentrations 0.079 0.0017 mg/m 3 , respectively. Statistically significant increased serum...
Objective We present quantitative exposure-response data on silica exposure in male Swedish iron foundry workers for cardiovascular, cerebrovascular, and respiratory morbidity. Methods This research is a cohort study of 2063 workers. From the National Patient Registers, morbidity incidence were retrieved. A historical measurement database 1667 respirable measurements from 10 foundries was used to calculate cumulative dose each worker. Results Increased risk whole group determined ischemic...
The NLRP3 inflammasome is a key regulator of inflammation that responds to broad range stimuli. exact mechanism activation has not been determined, but there consensus on cellular potassium efflux as major common denominator. Once activated, it forms high-order complexes together with NEK7 trigger aggregation ASC into specks. Typically, only one speck per cell, consistent the proposal specks form – or end up at centrosome. polymerisation in turn triggers caspase-1 activation, leading...
Stromal macrophages of different phenotypes can contribute to the expression proteins that affects metastasis such as urokinase-type plasminogen activator (uPA), its receptor uPAR, and inhibitor-1 (PAI-1), but knowledge how essential their contribution is in comparison cancer cells small cell lung (SCLC) squamous carcinoma (SCC) lacking. The uPA, PAI-1 matrix metalloproteinases (MMP)-2 MMP-9 were studied human M1 M2 phenotype compared a SCC (NCI-H520) SCLC (NCI-H69) line. Effects treatment...
The formation of prostaglandin E2 (PGE2) is associated with adverse inflammatory effects. However, long-term treatment nonsteroidal anti-inflammatory drugs (NSAIDs) comes risk severe side Therefore, alternative ways to inhibit PGE2 are warranted. We have investigated the effects tea extracts and polyphenols epigallocatechin gallate (EGCG) quercetin on formation, determined by immunoassay, protein expression, immunoblotting, cytosolic phospholipase A2 (cPLA2), cyclooxygenase 2 (COX-2)...
To study the relationship between inhalation of airborne particles and cobalt in Swedish hard metal industry markers inflammation coagulation blood.Personal sampling inhalable dust were performed for subjects two plants. Stationary measurements used to concentrations inhalable, respirable, total cobalt, PM10 PM2.5, particle surface area number concentrations. The inflammatory CC16, TNF, IL-6, IL-8, IL-10, SAA CRP, coagulatory FVIII, vWF, fibrinogen, PAI-1 D-dimer measured. A complete was on...
In light of potential negative health effects cobalt exposure, a characterization inflammatory mechanisms in exposed individuals is warranted. The current study investigated exposure the Swedish hard metal industry and its relationship to markers, including NLRP3 inflammasome activation white blood cell (WBC) counts.Inhalable dust exposures, systemic levels, were determined for 72 workers linear regression models applied correlate markers WBC counts.Mean exposures inhalable (0.11 mg/m3)...
Abstract Inflammation is a central mechanism in the aetiology of particulate matter (PM)-associated diseases, including cardiovascular diseases (CVD). Both acute inflammatory events and chronic low-grade inflammation due to exposure contribute adverse health effects exposure. The aim current study was determine if levels respirable quartz or dust at Swedish iron foundries induce systemic responses, using biomarkers broadly classified into three groups; 1) general markers inflammation, 2)...
Abstract The NLRP3 inflammasome is a key regulator of inflammation that responds to broad range stimuli. exact mechanism activation has not been determined, but there consensus on cellular potassium efflux as major common denominator. Once activated, it forms high-order complexes together with NEK7 trigger aggregation ASC into specks. Typically, only one speck per cell, consistent the proposal specks form – or end up at centrosome. polymerisation in turn triggers caspase-1 activation,...