A5030574118- Adenosine and Purinergic Signaling
- Receptor Mechanisms and Signaling
- Pharmacological Receptor Mechanisms and Effects
- Diverse academic and cultural studies
- Synthesis and Biological Evaluation
- Employment and Welfare Studies
- Italy: Economic History and Contemporary Issues
- Management, Economics, and Public Policy
- Italian Social Issues and Migration
- Social Policy and Reform Studies
- Regional Development and Policy
- Enzyme function and inhibition
- Labor Movements and Unions
- Synthesis and Catalytic Reactions
- Housing, Finance, and Neoliberalism
- Phenothiazines and Benzothiazines Synthesis and Activities
- Healthcare Systems and Challenges
- Economic Development and Digital Transformation
- Chemical Reactions and Mechanisms
- Economic Theory and Policy
- Migration, Aging, and Tourism Studies
- Educational and Social Studies
- Banking stability, regulation, efficiency
- Synthesis of β-Lactam Compounds
- Global Health Care Issues
University of Teramo
2023-2024
University of Florence
2014-2019
University of Siena
2019
In this study, we describe the design and synthesis of new N5-substituted-2-(2-furanyl) thiazolo[5,4-d]pyrimidine-5,7-diamines (2-18) their pharmacological characterization as A2A adenosine receptor (AR) antagonists by using in vitro vivo assays. competition binding experiments two derivatives (13 14) emerged outstanding ligands showing different affinity values (KH KL) for hA2A with high KH value femtomolar range. The functional activity assays, performed cyclic AMP experiments, assessed...
In this work, we describe the identification of 1,2,4-triazolo[4,3-a]pyrazin-3-one as a new versatile scaffold for development adenosine human (h) receptor antagonists. The chemotype ensued from molecular simplification approach applied to our previously reported 1,2,4-triazolo[4,3-a]quinoxalin-1-one series. Hence, set novel 8-amino-2-aryl-1,2,4-triazolopyrazin-3-one derivatives, featured by different substituents on 2-phenyl ring (R) and at position 6 (R6), was synthesized with main purpose...
In this paper, we describe the discovery of 3-hydroxyquinazoline-2,4-dione as a useful scaffold to obtain potent inhibitors tumor-associated human carbonic anhydrases (hCAs) IX and XII. A set derivatives (1-29), bearing different substituents on fused benzo ring (Cl, NO2, NH2, CF3, ureido, amido, heterocycles), were synthesized, several them showed nanomolar activity in inhibiting hCA XII isoforms, while they ineffective against cytosolic enzymes hCAs I II. Some selected compounds tested for...
A new series of amino-3,5-dicyanopyridines (1–31) was synthesized and biologically evaluated in order to further investigate the potential this scaffold obtain adenosine receptor (AR) ligands. In general, modifications performed have led compounds having high good human (h) A1AR affinity an inverse agonist profile. While most are hA1AR-selective, some derivatives behave as mixed hA1AR agonists/A2A A2B AR antagonists. The latter (9–12) showed that they reduce oxaliplatin-induced neuropathic...
New 7-amino-2-phenylpyrazolo[4,3-d]pyrimidine derivatives, substituted at the 5-position with aryl(alkyl)amino- and 4-substituted-piperazin-1-yl- moieties, were synthesized aim of targeting human (h) adenosine A1 and/or A2A receptor subtypes. On whole, novel derivatives 1–24 shared scarce or no affinities for off-target hA2B hA3 ARs. The 5-(4-hydroxyphenethylamino)- derivative 12 showed both good affinity (Ki = 150 nM) best selectivity hA2A AR while 5-benzylamino-substituted 5 displayed...
ABSTRACT Starting in the 1990s, healthcare legislation Italy gradually expanded powers and responsibilities of regions. In this context, focusing solely on National Health Service (NHS) may have limited our understanding regional‐level transformations over past decade. This article examines restructuring Italian Regional Services (SSR) from 2011 to 2021. We specifically analyse two key dimensions healthcare: ordinary hospital beds territorial structures, paying close attention their...
L’articolo analizza la concentrazione spaziale delle piattaforme di crowdsourcing in 11 paesi europei mostrando l’inappropriatezza degli approcci della teoria sulla varieta dei capitalismi e del concetto sistema nazionale dell’innovazione. Il fenomeno piu correttamente interpretabile utilizzando come unita analisi dimensione urbana. Le si addensano maggiormente citta metropolitane, ricche capitale umano qualificato caratterizzate da un clima fiducia negli altri.
This article focuses on changes in the European banks strategies and major transformations corporate governance occurred period 1997-2007. In this perspective, contrast with tenets of a part literature varieties capitalisms, we argue that there is limited convergence between coordinated non-coordinated market economies. first empirical analysis emphasizes persistence multiple equilibria state at national level, although trading assets gradually took place traditional activities...
The literature on analyzing organizations has devoted more to positive than failed cases. Nevertheless, the "dark side" represents one of constituent elements everyday organizational practices. Given these considerations, paper focuses possible perverse effects, myopias, and unexpected outcomes following "digital health" implementation. Through Tuscany Regional Health System case study qualitative methodologies based in-depth interviews, we want anticipate critical issues shortsightedness...