A5062390591- Cancer-related molecular mechanisms research
- RNA modifications and cancer
- Disability Education and Employment
- MicroRNA in disease regulation
- Lung Cancer Treatments and Mutations
- Cancer Genomics and Diagnostics
- Collaborative Teaching and Inclusion
- Epigenetics and DNA Methylation
- Cancer Immunotherapy and Biomarkers
- Molecular Biology Techniques and Applications
- Colorectal Cancer Treatments and Studies
- Genomic variations and chromosomal abnormalities
- Renal cell carcinoma treatment
- Digital Storytelling and Education
- DNA Repair Mechanisms
- Bladder and Urothelial Cancer Treatments
- Inflammasome and immune disorders
- Genetic factors in colorectal cancer
- Cancer, Stress, Anesthesia, and Immune Response
- Prostate Cancer Diagnosis and Treatment
- Teacher Education and Leadership Studies
- Advanced biosensing and bioanalysis techniques
- Cytokine Signaling Pathways and Interactions
- Genetic Associations and Epidemiology
- Lung Cancer Diagnosis and Treatment
Fox Chase Cancer Center
2024
Lafayette College
2018-2023
National Cancer Institute
2015-2021
Center for Cancer Research
2017-2021
The University of Texas MD Anderson Cancer Center
2019
National Cancer Institute
2017
Sidney Kimmel Comprehensive Cancer Center
2014
University of Pittsburgh
2014
Churchill Hospital
1998-1999
Abstract Purpose: To determine whether racial differences in gene and miRNA expression translates to lung tumor biology with clinical relevance African Americans (AAs) European (EAs). Experimental Design: The NCI-Maryland Case Control Study includes seven Baltimore City hospitals is overrepresented AA patients (∼40%). Patients that underwent curative NSCLC surgery between 1998 2014 were enrolled. Comparative molecular profiling used mRNA (n = 22 AAs 19 EAs) 42 55 arrays track paired fresh...
Abstract Reducing or eliminating persistent disparities in lung cancer incidence and survival has been challenging because our current understanding of biology is derived primarily from populations European descent. Here we show results a targeted sequencing panel using NCI-MD Case Control Study patient samples reveal significantly higher prevalence PTPRT JAK2 mutations adenocarcinomas among African Americans compared with Americans. This increase mutation frequency was validated independent...
Abstract Deciphering the post-transcriptional mechanisms (PTM) regulating gene expression is critical to understand dynamics underlying transcriptomic regulation in cancer. Alternative polyadenylation (APA)—regulation of mRNA 3′UTR length by alternating poly(A) site usage—is a key PTM mechanism whose comprehensive analysis cancer remains an important open challenge. Here we use method and pipeline that sequences 3′end-enriched RNA directly overcome saturation limitation traditional 5′–3′...
RC-160 (octastatin/vapreotide) is a potent octapeptide analogue of somatostatin with growth inhibitory activity in experimental tumours vitro and vivo, including breast cancer. We evaluated the efficacy tolerability high-dose RC-160, 3 mg day(-1) on week 1 increased to 4.5 for weeks 2-4 subsequently 6 until end treatment, administered by continuous subcutaneous infusion management 14 women previously treated metastatic The age range was 37-80 years (median 58.5 years) performance status 0-2....
Supporting instructor implementation of equitable and inclusive teaching approaches is a critical area focus in educational development. However, there limited empirical evidence on factors that either support or hinder instructors’ teaching. The results this national survey study reveal several predictors utilization reported obstacles faced. For sample, knowledge was statistically significant predictor implementation, as being from non-STEM discipline. Responses highlighted promising...
African Americans (AA) experience higher incidence and mortality of lung cancer as compared with European (EA). Inflammation is associated cancer, many aspects which differ between AA EA. We investigated whether use, frequency, duration the anti-inflammatory drug aspirin were risk survival, separately among EA populations.Using data from Maryland Non-Small Cell Lung Cancer (NSCLC) Case-Control Study (1,220 cases [404 816 EA] 1,634 controls [1,004 630 AA]), we estimated adjusted odds ratios...
Abstract DNA methylation is one of several epigenetic mechanisms used by cells to control gene expression. The de novo methyltransferases, DNMT3a and DNMT3b, establish new patterns during early development. DNMT1, the maintenance methyltransferase, ensures propagation hemi-methylated DNA. Human cancers are characterized aberrant patterns, including global hypomethylation hypermethylation promoters at tumor suppressor genes. This latter change leads transcriptional silencing. Experimentally,...