About
Contact & Profiles
A5002857044
Research Areas
- RNA Interference and Gene Delivery
- Autophagy in Disease and Therapy
- Lysosomal Storage Disorders Research
- Cellular transport and secretion
- Parkinson's Disease Mechanisms and Treatments
- HIV Research and Treatment
Yale University
2017
Glucocerebrosidase 1 ( GBA ) mutations responsible for Gaucher disease (GD) are the most common genetic risk factor Parkinson's (PD). Although link between GD and PD is well established, underlying molecular mechanism(s) not understood. We propose that glucosylsphingosine, a sphingolipid accumulating in GD, mediates pathology -associated PD. show that, whereas GD-related sphingolipids (glucosylceramide, sphingosine, sphingosine-1-phosphate) promote α-synuclein aggregation vitro ,...
10.1523/jneurosci.1525-17.2017
article
EN
cc-by-nc-sa
Journal of Neuroscience
2017-08-28
10.1016/j.ymgme.2016.11.338
article
EN
Molecular Genetics and Metabolism
2017-01-01
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