A5054157350- Terahertz technology and applications
- Acoustic Wave Resonator Technologies
- Photonic and Optical Devices
- Spectroscopy and Laser Applications
- Microwave Engineering and Waveguides
- Allergic Rhinitis and Sensitization
- Metamaterials and Metasurfaces Applications
- Advanced Chemical Sensor Technologies
- Analytical Chemistry and Chromatography
- Plasmonic and Surface Plasmon Research
- Thermography and Photoacoustic Techniques
- Advanced Antenna and Metasurface Technologies
- Drug Solubulity and Delivery Systems
- Spectroscopy and Chemometric Analyses
- Material Properties and Processing
- Protein purification and stability
- Cultural Heritage Materials Analysis
- Microwave and Dielectric Measurement Techniques
- Granular flow and fluidized beds
- Gold and Silver Nanoparticles Synthesis and Applications
- Food Drying and Modeling
- Powdery Mildew Fungal Diseases
- Antenna Design and Analysis
- Optical and Acousto-Optic Technologies
- Microwave-Assisted Synthesis and Applications
University of Cambridge
2014-2024
Finland University
2014-2022
University of Eastern Finland
2013-2022
Novel excipients are entering the market to enhance bioavailability of drug particles by having a high porosity and, thus, providing rapid liquid uptake and disintegration accelerate subsequent dissolution. One example such novel excipient is functionalized calcium carbonate, which enables manufacture compacts with bimodal pore size distribution consisting larger interparticle fine intraparticle pores. Five sets carbonate tablets target 45%-65% were prepared in 5% steps characterized using...
Abstract Porosity, one of the important quality attributes pharmaceutical tablets, directly affects mechanical properties, mass transport and hence tablet disintegration, dissolution ultimately bioavailability an orally administered drug. The ability to accurately quickly monitor porosity tablets during manufacture or manufacturing process will enable a greater assurance product quality. This tutorial systematically outlines steps involved in terahertz-based measurement method that can be...
Fully automated at-line terahertz time-domain spectroscopy in transmission mode is used to measure tablet porosity for thousands of immediate release tablets. The measurements are rapid and non-destructive. Both laboratory prepared tablets commercial samples studied. Multiple on individual quantify the random errors results. These show that refractive index precise, with standard deviation a single being about 0.002, variation between due small thickness measurement from resolution...
Cost effectiveness, ease of use and patient compliance make pharmaceutical tablets the most popular widespread form to administer a drug patient. Tablets typically consist an active ingredient selection from various excipients. A novel highly porous excipient, functionalised calcium carbonate (FCC), was designed facilitate rapid liquid uptake leading disintegration times FCC based in matter seconds. Five sets with target porosity 45–65% 5% steps were prepared characterised using terahertz...
In the field of non-destructive testing, terahertz sensing has been used to analyze a wide range materials where most successful applications have involved that are semi-transparent radiation. this work, we demonstrate sensitivity time-domain spectroscopy quantify water absorption in hygrothermally aged simple and commercial epoxy systems supported by conventional gravimetric analysis.
The need for wideband metamaterial absorbers (WBMA) applications other than sensing and filtering has demanded modifications to the conventional three-layer metal-insulator-metal (MIM) absorber configuration. This modification often results in complex geometries an increased number of layers requiring lithographic processes fabrication. Here, we show that a with rectangular geometry simple MIM configuration can provide absorption covering ultraviolet near-infrared spectral range. Due its...
Pharmaceutical tablet disintegration is a critical process for dissolving and enabling the absorption of drug substance into blood stream. The consists multiple connected interdependent mechanisms: liquid penetration, swelling, dissolution, break-up. One key dependence dynamic change pore space in caused by swelling particles while takes up liquid. This study analysed changes structure during coupling discrete element method (DEM) with single-particle model experimental penetration data from...
Liquid fuel adulteration has several far-reaching impacts such as environmental pollution. A widespread practice is typically the of diesel oil by kerosene. The relatively cheap price kerosene probably most important reason for its usage in illegal adulteration. Herein, we demonstrate use a prototype optical sensor efficient tracking adulterated oil. In this study, an screening fake proposed. device exploits phenomenon laser light reflection from film over roughened glass plate. sensing...
Abstract Metamaterial absorbers display potential applications in the field of photonics and have been investigated extensively during last decade. We propose a dual-band resonant metamaterial absorber with right-angle shaped elements (RAEs) terahertz range based on numerical simulations. The remains insensitive to wide incidence angles (0°–70°) by showing minimum absorbance ~80% at 70°. Furthermore, proposed is highly independent any state polarization electromagnetic wave due high...
This study evaluated the potential of poly(ethylene vinyl acetate) (EVA) copolymers as matrix formers in miniaturised implants, allowing to achieve controlled drug delivery into inner ear. Due blood-cochlea barrier, it is impossible reliably deliver a this tiny and highly sensitive organ clinical practice. To overcome bottleneck, different EVA implants were prepared by hot melt extrusion, altering acetate content implant diameter. Dexamethasone was incorporated with anti-inflammatory...