A5039660156- IL-33, ST2, and ILC Pathways
- Inflammasome and immune disorders
- 3D Modeling in Geospatial Applications
- Gene expression and cancer classification
- Immune Cell Function and Interaction
- Biomedical and Engineering Education
- Single-cell and spatial transcriptomics
- Autoimmune and Inflammatory Disorders Research
- Geographic Information Systems Studies
- Bioinformatics and Genomic Networks
Helmholtz Zentrum München
2024
Leibniz-Institut für Naturstoff-Forschung und Infektionsbiologie e. V. - Hans-Knöll-Institut (HKI)
2022-2023
Abstract Spatially resolved omics technologies are transforming our understanding of biological tissues. However, the handling uni- and multimodal spatial datasets remains a challenge owing to large data volumes, heterogeneity types lack flexible, spatially aware structures. Here we introduce SpatialData, framework that establishes unified extensible multiplatform file-format, lazy representation larger-than-memory data, transformations alignment common coordinate systems. SpatialData...
Abstract It has been shown that innate immune responses can adopt adaptive properties such as memory. Whether T cells utilize signaling pathways to diversify their repertoire of effector functions is unknown. Gasdermin E (GSDME) a membrane pore-forming molecule execute pyroptotic cell death and thus serve potential cancer checkpoint. In the present study, we show human express GSDME and, surprisingly, this expression associated with durable viability repurposed for release alarmin...
During a three-day hackathon, work was performed on various topics within the field of spatial omics data analysis. The were organized in five workgroups and included benchmarking, pipelines, transcriptomics, proteomics, multi-omics cell-cell communication. Most tools methods considered context Python ecosystem for (SpatialData) single-cell (scverse)
This pre-print is aimed at sharing the results of "1st SpatialData workshop," an in-person event organized by team and funded Chan Zuckerberg Initiative (CZI) that brought together expertise from different fields, including methods developers a variety tools for single-cell spatial omics. The purpose to explore new directions advance field By leveraging multiple programming languages, Python, R, JavaScript, focuses on four central hackathon tracks: R interoperability: track aims enhance...