Adult stem cell research has been advanced in recent years because of the cells' attractive abilities self-renewal and differentiation. Topography materials is one key features that can be harnessed to regulate behaviors. Stem cells interact with underlying material through nanosized integrin receptors. Therefore, manipulation topographical cues at a nanoscale level employed modulate fate. In this review, we focus our discussion on different surface cues, especially, an emphasis viral...

All lined up: Diverse patterns result from drying a solution of tobacco mosaic virus (TMV) particles in glass capillary tube (see AFM images). The hierarchical assembled structure can be controlled by the particle concentration, process, and surface properties interior tube. internally patterned potentially applied to directing orientation rat aortic smooth muscle cells. Detailed facts importance specialist readers are published as ”Supporting Information”. Such documents peer-reviewed, but...

Simulation for the smooth muscle layer of blood vessel plays a key role in tubular tissue engineering. However, fabrication biocompatible tube with defined inner nano/micro-structure remains challenge. Here, we show that polymer from poly(l-lactide) (PLLA) and polydimethylsiloxane (PDMS) can be prepared by using electrospinning technique, assistance rotating collector parallel auxiliary electrode. The has circumferentially aligned PLLA fibers surface cell growth regulation PDMS coating...

A facile and robust method to align one-dimensional (1D) nanoparticles (NPs) in large scale has been developed. Using flow assembly, representative rod-like nanoparticles, including tobacco mosaic virus (TMV), gold nanorods, bacteriophage M13, have aligned inside glass tubes by controlling rate substrate surface properties. The properties of 1D NPs, such as stiffness aspect ratio, play a critical role the alignment. Furthermore, these hierarchically organized structures can be used support...

This study focuses on the development of injectable hydrogels to mimic cartilage microenvironment using hyaluronic acid (HA) derivatives as starting materials. Cysteine-inserted Tobacco mosaic virus (TMV) mutants (TMV1cys) could be cross-linked methacrylated (MeHA) polymers by thiol-ene "click" chemistry and form under physiological condition. The resulting promote in vitro chondrogenesis bone marrow mesenchymal stem cells (BMSCs) significantly higher than that TMV-free HA upregulating...

Injectable low-molecular-weight hydrogels (LMWHs) from biocompatible materials have attracted much attention in biomedical applications because they can adapt any desired sizes and cavity shapes. Searching for simple, injectable LMWHs owning inherent antibacterial activity without complicated chemical modification remains an open question to avoid the tedious synthesis/purification process easy bacterial infection of a moist environment. In this work, glycyrrhizic acid (GL), naturally...

Bacteria-mediated infectious diseases have become a health-care challenge globally since the development of antibiotic resistance. Reactive oxygen species produced by photosensitizers great potential in fighting bacterial infections, especially against Gram-negative bacteria that are hard to kill regular methods owing their formidable defensive membrane structures under premise avoiding overuse antibiotics. In this work, small molecular photosensitizer, curcumin (CCM), was used as model and...

RNA−coat protein interactions in intact tobacco mosaic virus have been investigated for the first time directly on single-molecule level by pulling genetic RNA step out of helical groove formed its coat. The effects speed and pH RNA−protein are presented. In addition, rebinding behavior detached with coat is discussed. Our results demonstrate possibility studying nucleic acid−protein more complicated systems using AFM-based force spectroscopy.

Journal Article A plant virus substrate induces early upregulation of BMP2 for rapid bone formation Get access Pongkwan Sitasuwan, Sitasuwan Department Chemistry and Biochemistry, University South Carolina, 631 Sumter Street, Columbia, SC 29208, USA. Fax: +1 803 777 9521; Tel: 8436 Search other works by this author on: Oxford Academic Google Scholar L. Andrew Lee, Lee Peng Bo, Bo State Key Laboratory Polymer Physics Chemistry, Changchun Institute Applied Chinese Academy Sciences, 130022, PR...

Electroactive nanofibers were fabricated by in situ polymerization of aniline on the surface tobacco mosaic virus (TMV) using sodium poly(styrenesulfonate) (PSS) as dopant. These electroactive TMV/PANi/PSS employed to support growth neuronal cells, resulting augmentation length neurites. In addition, percentage cells with neurites was increased comparison cultured TMV-derived nonconductive nanofibers. The TMV-based could be aligned capillaries that guide outgrowth direction neurites,...

We report here the synthesis of a light- and chemical-responsive supramolecular hydrogel bacteriophage M13 hyaluronan locked by molecular recognition between β-cyclodextrin trans-azobenzene moieties. Compared to rod-like tobacco mosaic virus (TMV), filamentous with higher aspect ratio more flexible structure formed much robust hyaluronan, which was confirmed inversion test rheological measurement. The resulting showed sol–gel transition behaviours induced either photo-irradiation or...

Tobacco mosaic virus (TMV) has been studied as a multi-functional agent for bone tissue engineering. An osteo-inductive effect of wild-type TMV reported, it can significantly enhance the differentiation potential marrow stromal cells both on two-dimensional substrate and in three-dimensional (3D) hydrogel system. A mutant (TMV-RGD1) was created which featured adhesion peptide arginyl-glycyl-aspartic acid (RGD), most common motif responsible cell to extracellular matrix, surface particle...

Nitric oxide (NO) is an emerging and promising antimicrobial agent for treating biofilms, yet its enrichment in biofilms has become a major challenge. In this contribution, iron oxide-polydopamine (Fe3O4-PDA) core–shell nanoparticles were fabricated then loaded with (N,N′-di-sec-butyl-N,N′-dinitroso-1,4-phenylenediamine, BNN6), NO donor, to yield magnetic field-driven near-infrared (NIR)-responsive delivery system biofilm treatment. field, the found penetrate into accumulate more...

A novel method to tune surface wettability rapidly and reversibly has been developed by ion exchange of the counterions at a multilayer film assembled via electrostatic interaction.

Counterions present at the surface of polyelectrolyte multilayers (PEMs) were utilized for modulation wettability via ion exchange. The PEM film was dipped in aqueous solutions different anions, respectively, and water contact angle varied from about 10° to 120°, depending on hydration characteristics anion. exchange mechanism verified by X-ray photoelectron spectroscopy. process rapid reversible. Ionic strength solution used preparing PEMs found be crucial wetting properties reversibility...

Dynamic self-assembly of nonvolatile solutes via controlled solvent evaporation has been exploited as a simple route to create variety hierarchically assembled structures. In this work, two glass slides were used form confined space in which solution rodlike nanoparticle, tobacco mosaic virus (TMV), was evaporated large-scale stripe patterns. The height and width the stripes are dependent on TMV concentration. large-scale-patterned surfaces can be applied control surface hydrophobicity...

Based on the precise nano-architecture of bacteriophage M13, a FRET-based fluorescent nanosensor has been formulated for ratiometric sensing intracellular pH.

Using a one-pot approach driven by the supramolecular interaction between β-cyclodextrin and adamantyl moieties, multifunctional viral nanoparticles can be facilely formulated for biomedical applications.