A5025460548- Inflammatory Bowel Disease
- Colorectal Cancer Surgical Treatments
- SARS-CoV-2 and COVID-19 Research
- Anorectal Disease Treatments and Outcomes
- COVID-19 Clinical Research Studies
- T-cell and B-cell Immunology
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Healthcare Systems and Public Health
- Colorectal Cancer Screening and Detection
- Hip and Femur Fractures
- Diversity and Career in Medicine
- Surgical site infection prevention
- Long-Term Effects of COVID-19
- Colorectal and Anal Carcinomas
- Cardiac, Anesthesia and Surgical Outcomes
- COVID-19 epidemiological studies
- Surgical Simulation and Training
- Total Knee Arthroplasty Outcomes
- Immune Response and Inflammation
- Pregnancy and Medication Impact
- Orthopaedic implants and arthroplasty
- Orthopedic Infections and Treatments
- Legal and Regulatory Analysis
- Wound Healing and Treatments
- Immune Cell Function and Interaction
Austin Health
2021-2024
St Vincent's Hospital
2022-2024
Sir Charles Gairdner Hospital
2024
Australia and New Zealand Banking Group
2023
Northern Hospital
2020
The Royal Melbourne Hospital
2012
Recent studies have established that memory B cells, largely thought to be circulatory in the blood, can take up long-term residency inflamed tissues, analogous widely described tissue-resident T cells. The dynamics of recruitment and retention cells tissues their immunological purpose remains unclear. Here, we characterized (B RM ) are stably maintained lungs mice after pulmonary influenza infection. Influenza - specific were localized within inducible bronchus-associated lymphoid (iBALTs)...
Abstract Background Reversal of ileostomy is associated with morbidity including wound infection and prolonged healing. Negative pressure therapy (NPWT) has been shown to reduce time healing by secondary intention. The aim this study was determine whether NPWT improved rates, compared simple dressings, in patients undergoing reversal where the skin closed a purse‐string suture. Methods This dual‐centre, open‐label, randomized controlled trial two parallel intervention arms. Patients elective...
Debate still exists for the management of choledocholithiasis. The purpose this study is to quantify rate recurrent choledocholithiasis post choledochoscopic bile duct exploration (CBDE) in comparison ERCP and sphincterotomy, demonstrate feasibility approach a busy metropolitan hospital. Data patients undergoing CBDE from 2009-2014 at Northern Hospital, Victoria, Australia, was collected retrospectively. Primary outcomes were clearance stones post-clearance. Secondary measured post-operative...
Endemic human coronaviruses (hCoVs) circulate worldwide but cause minimal mortality. Although seroconversion to hCoV is near ubiquitous during childhood, little known about hCoV-specific T-cell memory in adults.We quantified CD4 and antibody responses spike antigens 42 SARS-CoV-2-uninfected individuals. Antigen-specific T cells circulating follicular helper (cTFH) were identified using an activation-induced marker assay characterised for phenotype chemokine receptor expression.T-cell...
In 2014, infliximab (IFX) was listed on the Australian Pharmaceutical Benefits Scheme for acute severe ulcerative colitis (ASUC) and is now preferred option medical salvage, superseding cyclosporin A (CsA). Optimal dosing schedules IFX remain unknown.The authors aim to evaluate effect of changing from predominantly CsA almost exclusively treatment steroid-refractory ASUC colectomy rates.A retrospective review performed patients admitted with between 2012 2020. Patients were categorised into...
Abstract Endemic human coronaviruses (hCoV) circulate worldwide but cause minimal mortality. Although seroconversion to hCoV is near ubiquitous during childhood, little known about hCoV-specific T cell memory in adults. We quantified CD4 and antibody responses spike antigens 42 SARS-CoV-2 uninfected individuals. were widespread within conventional cTFH compartments did not correlate with IgG titres. cross-reactive cells observed 48% of participants correlated HKU1 memory. exhibited a CCR6 +...
Abstract Background The COVID‐19 pandemic disrupted the provision of surgical services in Australia. To prepare for a surge patients, elective surgery was mandatorily reduced or ceased at multiple timepoints Australian states between 2020 and 2022. Operative exposure is critical component training general surgery, readiness practice an ongoing priority. However, impact on operative General Surgical Trainees (AGST) has not been quantified. Methods This study retrospective longitudinal cohort...
The optimal management of patients with clinical complete response after neoadjuvant treatment for rectal cancer is controversial. aim this study to compare the morbidity between locally advanced who have had a pathological (pCR) or not chemoradiotherapy (NCRT) and total mesorectal excision (TME). hypothesis was that pCR may impact surgical complication rate.