About
Contact & Profiles
A5079668606
Research Areas
- DNA Repair Mechanisms
- DNA and Nucleic Acid Chemistry
- Genomics and Chromatin Dynamics
Brown University
2017-2019
10.1016/j.dnarep.2017.08.010
article
EN
DNA repair
2017-09-02
Alkyladenine DNA glycosylase (AAG) is the only known human capable of excising alkylated purines from DNA, including highly mutagenic 1,N6-ethenoadenine (εA) lesion. Here, we examine ability AAG to excise εA a nucleosome core particle (NCP), which primary repeating unit packaging in eukaryotes. Using chemical synthesis techniques, assembled global population NCPs A replaced with εA. While each NCP contains no more than one lesion, total 49 distinct geometric positions. this εA-containing...
10.1021/acschembio.9b00263
article
EN
ACS Chemical Biology
2019-07-16
Coming Soon ...