A5052460109- Bone Tissue Engineering Materials
- Nanoplatforms for cancer theranostics
- Immunotherapy and Immune Responses
- RNA Interference and Gene Delivery
- Cancer Immunotherapy and Biomarkers
- Dental Implant Techniques and Outcomes
- Endodontics and Root Canal Treatments
- Nanoparticle-Based Drug Delivery
- Antimicrobial Peptides and Activities
- Electrospun Nanofibers in Biomedical Applications
- Graphene and Nanomaterials Applications
- biodegradable polymer synthesis and properties
- Anaerobic Digestion and Biogas Production
- Polymer Surface Interaction Studies
- Orthopaedic implants and arthroplasty
- Combustion and flame dynamics
- Dental materials and restorations
- Wastewater Treatment and Nitrogen Removal
- Immune cells in cancer
- Combustion and Detonation Processes
- Advanced Combustion Engine Technologies
- Tissue Engineering and Regenerative Medicine
- Calcium Carbonate Crystallization and Inhibition
- Aluminum Alloys Composites Properties
- Boron and Carbon Nanomaterials Research
National Institute of Advanced Industrial Science and Technology
2015-2024
Shandong University of Technology
2024
National Institute for Materials Science
2024
Institute of Zoology
2017
Chinese Academy of Sciences
2007-2017
Shangqiu Institute of Technology
2009-2013
Tianjin Economic-Technological Development Area
2013
Beijing Institute of Technology
2011
South China University of Technology
2005-2009
Xi'an Jiaotong University
2004-2008
Abstract High global incidence of prostate cancer has led to a focus on prevention and treatment strategies reduce the impact this disease in public health. Boron compounds are increasingly recognized as preventative chemotherapeutic agents. However, systemic administration soluble boron is hampered by their short half-life low effectiveness. Here we report hollow nitride (BN) spheres with controlled crystallinity release that decrease cell viability increase apoptosis. In vivo experiments...
The use of appropriate adjuvants that support the generation robust and long-lasting antitumor immune responses is crucial for tumor immunotherapy owing to immunosuppressive environment growing tumor. However, most commonly used adjuvant, aluminum hydroxide, ineffective generating such therefore not suitable cancer immunotherapy. It now shown plain hollow mesoporous silica nanospheres markedly improve immunity, Th1 Th2 CD4(+) CD8(+) effector memory T cell population in bone marrow vivo may...
Modern vaccines usually require accompanying adjuvants to increase the immune response antigens. Aluminum (alum) compounds are most commonly used in human vaccinations for infection diseases. However, alum nondegradable, cause side effects due persistence of at injection sites, and rather ineffective cancer immunotherapy, which requires Th1 response. Recently, we have shown that a plain mesoporous silica (MS) adjuvant can stimulate anticancer immunity vaccines. Herein, MS nanospheres doped...
Hollow and non-hollow mesoporous silica nanospheres are synthesized used for cancer vaccine adjuvants. The hollow structure of significantly promote cellular uptake a model antigen by macrophage-like cells in vitro, improve anti-cancer immunity, CD4(+) CD8(+) T cell populations splenocytes mice vivo.
Checkpoint blockade therapy has provided noteworthy benefits in multiple cancers recent years; however, its clinical remain confined to 10-40% of patients with extremely high costs. Here, we design an ultrafast, low-temperature, and universal self-assembly route integrate immunology-associated large molecules into metal-organic-framework (MOF)-gated mesoporous silica (MS) as cancer vaccines. Core MS nanoparticles, acting intrinsic immunopotentiator, provide the niche, void, space accommodate...
Hierarchically porous bioactive glass (CaO−SiO2−P2O5) scaffolds have been prepared by using nonionic block copolymer EO20PO70EO20 (P123) and polyurethane (PUF) as cotemplates. It exhibits a hierarchical structure with interconnected macropores (about 200−400 or 500−700 μm), which provide the potential for tissue ingrowth neovascularization, uniform mesopores (3.68 nm), cause an increase in specific surface area enhanced bioactivity release of ionic products. The ordered hierarchically...
Abstract Anti‐washout‐type calcium phosphate cement (aw‐CPC) was prepared by introducing chitosan, sodium alginate, or modified starch into the powder phase of CPC, respectively. The results showed that these cements cannot be washed out and set within approximately 10–30 min even if pastes were immersed in distilled water immediately shaken a shaker after mixing moulding. To our knowledge, it is first report about influence content anti‐washout additives on rheological properties...
A plain mesoporous silica nanoparticle without any immunomodulatory molecules significantly enhances anticancer immunity in vivo. Comprehensive mechanism of mesoporous‐silica‐nanoparticle‐induced cancer immunotherapy is analyzed this paper. The promotes both Th1 and Th2 immune responses, as it accelerates lymphocytes proliferation, stimulates IFN‐γ, IL‐2, IL‐4, IL‐10 cytokine secretion by ex vivo, increases IgG, IgG1, IgG2a, IgM, IgA antibody titers mice serum compared with those alum...
Abstract The interaction between boron nitride nanotubes (BNNTs) layer and mesenchymal stem cells (MSCs) is evaluated for the first time in this study. BNNTs supports attachment growth of MSCs exhibits good biocompatibility with MSCs. show high protein adsorption ability, promote proliferation increase secretion total by Especially, enhance alkaline phosphatase (ALP) activity as an early marker osteoblasts, ALP/total osteocalcin (OCN) a late osteogenic differentiation, which shows that can...
Mesoporous CaO–MO–SiO2–P2O5 (M = Mg, Zn, Cu) bioactive glasses/composites have been prepared by a one-pot synthesis route of simultaneous evaporation-induced self-assembly Ca, P, Si and M sources. The effects the substitution CaO MO in mesoporous on structure hydroxyapatite (HA)-forming ability were studied. amorphous silicate can be detected all glasses/composites, Zn2SiO4 CuO clearly glass with high Zn contents Cu-containing respectively. MgO-substituted show highest surface area among...