A5028502018- Medical Imaging Techniques and Applications
- Advanced X-ray and CT Imaging
- Advanced X-ray Imaging Techniques
- Advanced Radiotherapy Techniques
- Radiation Therapy and Dosimetry
- Nuclear Physics and Applications
- Molecular spectroscopy and chirality
- Laser-Plasma Interactions and Diagnostics
- Radiation Detection and Scintillator Technologies
- Radiation Dose and Imaging
- Nonlinear Photonic Systems
- Digital Radiography and Breast Imaging
- Atomic and Molecular Physics
- Advanced MRI Techniques and Applications
- Salivary Gland Tumors Diagnosis and Treatment
- Spectroscopy and Quantum Chemical Studies
- Particle accelerators and beam dynamics
- Meningioma and schwannoma management
- Photorefractive and Nonlinear Optics
- Neurofibromatosis and Schwannoma Cases
- Advanced Chemical Physics Studies
- Atomic and Subatomic Physics Research
- Extracellular vesicles in disease
- Mechanical and Optical Resonators
- Advanced Fiber Laser Technologies
University of California, Irvine
2020-2025
Beckman Laser Institute and Medical Clinic
2022-2025
California State University, Long Beach
2023
Abstract Background K‐edge subtraction (KES) imaging is a dual‐energy technique that enhances contrast by subtracting images taken with x‐rays are above and below the energy of specified agent. The resulting reconstruction spatially identifies where agent accumulates, even when obscured complex heterogeneous distributions human tissue. This method most successful x‐ray sources quasimonoenergetic tunable, conditions have traditionally only been met at synchrotrons. Laser‐Compton (LCSs)...
The Distributed Charge Compton Source (DCCS) developed by Lumitron Technologies, Inc. has produced a 25-MeV electron beam with 1.7-nC macrobunches at 100-Hz repetition rate from compact, high-gradient X-band (11.424 GHz) accelerator. DCCS is currently being commissioned to produce 100-MeV-class electrons, well within the very high energy (VHEE) regime, macrobunch charges of up 25 nC rates 400 Hz. also designed imaging X rays through Laser scattering. This work aims describe preparations for...
An open-source code, arbitrary laser fields for particle-in-cell (ALFP), is provided to enable the use of accurately focused beam structures in (PIC) simulations, and used demonstrate utility space-time coupled beams ion acceleration. ALFP provides significant flexibility simulating with complex space, time, polarization couplings PIC simulations. This facilitates exploration laser–matter interactions beyond standard Gaussian pulse interaction. Additionally, polychromatic focusing effects...
Abstract Objectives To compare two statistical models, namely logistic regression and artificial neural network (ANN), in prediction of vestibular schwannoma (VS) recurrence. Methods Seven hundred eighty‐nine patients with VS diagnosis completed an online survey. Potential predictors for recurrence were derived from univariate analysis by reaching the cut off P value .05. Those nine potential years since treatment, surgeon's specialty, resection amount, having incomplete eye closure, dry...
Conventional x-ray sources for medical imaging utilize bremsstrahlung radiation. These generate large bandwidth (BW) spectra with fractions of photons that impart a dose, but do not contribute to image production. X-ray based on laser-Compton scattering can have inherently small energy BWs and be tuned low dose-imparting energies, allowing them take advantage atomic K-edge contrast enhancement. This paper investigates the use gadolinium-based subtraction in context mammography using source...
Electron beams used in laser-Compton X-ray sources can be utilized as ultra-high dose rate (UHDR) ionizing radiation if the architecture provides sufficient peak current and beam energy. Using a multi-step simulation workflow, we identify commensurate electron profiles for image-guided UHDR (FLASH) radiotherapy experiments.
A numerical analysis of spatially chirped beams produced by single-pass grating pairs is presented. It shown that focused pulse structures can deviate significantly relative to standard linear spatial chirp approximations depending upon the bandwidth, angle incidence, and groove density gratings used.
The design and optimization of laser-Compton x-ray systems based on compact distributed charge accelerator structures can enable micron-scale imaging disease the concomitant production beams Very High Energy Electrons (VHEEs) capable producing FLASH-relevant dose rates. physics scattering ensures that scattered x-rays follow exactly trajectory incident electrons, thus providing a route to image-guided, VHEE FLASH radiotherapy. keys architecture both VHEEs are use X-band RF which have been...
The development of compact quasimonoenergetic x-ray radiation sources based on laser Compton scattering (LCS) offers opportunities for novel approaches to medical imaging. However, careful experimental design is required fully utilize the angle-correlated spectra produced by LCS sources. Direct simulations are computationally expensive and difficult employ in optimization. In this manuscript, we present a computational method that characterizes at any end point energy within range defined...
We present a method to simulate ultrafast pump-probe time-resolved circular dichroism (TRCD) spectra based on time-dependent density functional theory trajectory surface hopping. The is applied the TRCD spectrum along photoinduced ring-opening of provitamin D. Simulations reveal that initial decay signal due excited state relaxation, forming rotationally flexible previtamin further show oscillations in experimental arise from isomerizations between D rotamers with different chirality, which...
Nuclear resonance fluorescence is the process by which atomic nuclei absorb and emit radiation. We discuss possibility of using laser-Compton sources to interrogate these transitions for isotope selective biological functional imaging.
A single energy tuning, K-edge subtraction imaging method using laser-Compton sources (LCS) is presented. The narrow spectral bandwidths that LCSs provide can improve clinical dualenergy mammography by 1000x in contrast enhancement or dose reduction.
The intensity of nuclear resonant transitions is largely dominated by atomic motion. Laser-Compton sources have the capability to measure these Doppler spectrum shifts and a method velocity measurements presented.
Nuclear resonance fluorescence is the process by which atomic nuclei absorb and emit radiation. Around these resonances, refractive index changes according to Kramers-Kronig relations. We discuss how measure such physics using laser-Compton sources.
Laser-Compton x-ray sources have many advantages over traditional tubes for use in medical imaging due to their monoenergetic energy spectrum, tunability, high-flux, and low-dose potential. These properties can specifically be taken advantage of the context K-edge subtraction (KES) imaging. Previous optimization approaches are time-consuming by scanning high-dimensional parameter spaces. Here, we show how a Bayesian routine optimizes LCS source parameters only fraction computational time....
Tuning the Compton edge energy of a Laser X-ray source is difficult on experimental time scale for K-edge subtraction (KES) imaging. Scanning KES imaging can overcome this difficulty by utilizing angle-correlated spectra.
We present a method to simulate ultrafast pump-probe time-resolved circular dichroism (TRCD) spectra based on time-dependent density functional theory trajectory surface hopping. The is applied the TRCD spectrum along photoinduced ring-opening of provitamin D. Simulations reveal that initial decay signal due excited state relaxation, forming rotationally flexible previtamin further show oscillations in experimental arise from isomerizations between D rotamers with different chirality, which...
Tunable quasi-monoenergetic MeV gamma rays of 100 fs have never been produced. Extremely brilliant Compton sources (EBCSs) can produce tunable at energies, but typically picosecond pulse timescales. We present here how the duration be moved to ~100 energies using EBCSs.
<h3>Objective:</h3> To characterize the effect of activation interferome in human organoids toward understanding cortical neuronal dysfunction. <h3>Background:</h3> The mechanisms by which maternal infection and neuroinflammation impact brain development, function, repair remain unclear. IFN-g is a proinflammatory cytokine found elevated serum pregnant mothers with children diagnosed autism Th1 cells cerebrospinal fluid multiple sclerosis patients. <h3>Design/Methods:</h3> Nearly three...
Spatially resolved Laser Compton X-ray spectra are computationally expensive to simulate and thus difficult utilize in precision optimization tasks. Through discretized interpolation we report a reliable efficient approach for rapid production of spectra.
An optimization of laser-Compton scattering sources for medically-relevant, K-edge subtraction imaging with gadolinium contrast agents is presented. Careful choice source, on-axis X-ray energy and bandwidth enable potential reductions in patient dose nearly 30x.