A5080188989- Ocular Surface and Contact Lens
- Glaucoma and retinal disorders
- Corneal surgery and disorders
- Ocular Infections and Treatments
- Retinal Diseases and Treatments
- Intraocular Surgery and Lenses
- Retinal Imaging and Analysis
- Pain Mechanisms and Treatments
- Ophthalmology and Visual Impairment Studies
- Corneal Surgery and Treatments
- Diabetic Foot Ulcer Assessment and Management
- Bee Products Chemical Analysis
- Immunotherapy and Immune Responses
- Botulinum Toxin and Related Neurological Disorders
- Skin Protection and Aging
- Retinal and Optic Conditions
- Pediatric health and respiratory diseases
- Retinopathy of Prematurity Studies
- Advanced Glycation End Products research
- Ocular Oncology and Treatments
- Advancements in Transdermal Drug Delivery
- Visual perception and processing mechanisms
- Optical Coherence Tomography Applications
- Healthcare and Venom Research
- Facial Rejuvenation and Surgery Techniques
Queensland University of Technology
2016-2025
Vision Cooperative Research Centre
2005-2021
UNSW Sydney
2003-2017
Brien Holden Vision Institute
2007-2017
Princess Alexandra Hospital
2013-2016
National Health and Medical Research Council
2012-2016
Juvenile Diabetes Research Foundation
2012-2016
The University of Queensland
2012-2016
Weill Cornell Medical College in Qatar
2016
University of Manchester
2013-2016
OBJECTIVE This study determined if deficits in corneal nerve fiber length (CNFL) assessed using confocal microscopy (CCM) can predict future onset of diabetic peripheral neuropathy (DPN). RESEARCH DESIGN AND METHODS CNFL and a range other baseline measures were compared between 90 nonneuropathic patients with type 1 diabetes who did or not develop DPN after 4 years. The receiver operator characteristic (ROC) curve was used to determine the capability single combined DPN. RESULTS developed 16...
Small cohort studies raise the hypothesis that corneal nerve abnormalities (including fibre length [CNFL]) are valid non-invasive imaging endpoints for diabetic sensorimotor polyneuropathy (DSP). We aimed to establish concurrent validity and diagnostic thresholds in a large of participants with without DSP. Nine hundred ninety-eight from five centres (516 type 1 diabetes 482 2 diabetes) underwent CNFL quantification clinical electrophysiological examination. AUC were derived validated...
Arbitrary numbers of corneal confocal microscopy images have been used for analysis subbasal nerve parameters under the implicit assumption that these are a representative sample central plexus. The purpose this study is to present technique quantifying number random required achieve an acceptable level accuracy in measurement fiber length and branch density.Every possible combination 2 16 (where was deemed true mean) plexus, not overlapping by more than 20%, were assessed density 20...
Purpose This study investigated independent risk factors and causative organisms in microbial keratitis daily disposable contact lens (CL)-wearers. Methods A multisite prospective case-control was undertaken. Cases were CL-wearers attending Moorfields Eye Hospital with those reported through a one-year surveillance Australia New Zealand. population-based telephone survey identified CL-wearing controls. Subjects completed questionnaire describing CL-wear history, hygiene demographics. The...
purpose. To examine factors influencing the severity of soft contact lens (SCL)–related microbial keratitis. methods. Cases were detected via surveillance studies in Australia and New Zealand. Factors affecting disease (costs, days symptoms, 2 or more lines vision loss) examined included age; gender; delay SCL removal, seeking consultation, receiving treatment; overnight wear; material (hydrogel silicone hydrogel [SiH]); causative organism. results. Two hundred ninety-seven cases identified:...
Purpose: To analyze the repeatability of measuring nerve fiber length (NFL) from images human corneal subbasal plexus using semiautomated software. Methods: Images were captured corneas 50 subjects with type 2 diabetes mellitus who showed varying severity neuropathy, Heidelberg Retina Tomograph 3 Rostock Corneal Module. Semiautomated analysis software was independently used by two observers to determine NFL plexus. This procedure undertaken on occasions, days apart. Results: The intraclass...
Background: For those in the field of managing diabetic complications, accurate diagnosis and monitoring peripheral neuropathy (DPN) continues to be a challenge. Assessment sub‐basal corneal nerve morphology has recently shown promise as novel ophthalmic marker for detection DPN.Methods: Two hundred thirty‐one individuals with diabetes predominantly mild or no 61 controls underwent evaluation symptom score, disability testing 10-g monofilament, quantitative sensory (warm, cold, vibration...
The aim of the study was to determine association, agreement, and detection capability manual, semiautomated, fully automated methods corneal nerve fiber length (CNFL) quantification human subbasal plexus (SNP).Thirty-three participants with diabetes 17 healthy controls underwent laser scanning confocal microscopy. Eight central images SNP were selected for each participant analyzed using manual (CCMetrics), semiautomated (NeuronJ), (ACCMetrics) software quantify CNFL.For entire cohort, mean...
To investigate the relationship between retinal nerve fibre layer thickness and peripheral neuropathy in patients with Type 2 diabetes, particularly those who are at higher risk of foot ulceration.Global sectoral thicknesses were measured 3.45 mm diameter around optic head using optical coherence tomography (OCT). The level was assessed 106 participants (82 diabetes 24 healthy controls) 0-10 disability score. Participants stratified into four groups: none (0-2), mild (3-5), moderate (6-8),...
OBJECTIVE Corneal nerve fiber length (CNFL) represents a biomarker for diabetic distal symmetric polyneuropathy (DSP). We aimed to determine the reference distribution of annual CNFL change, prevalence abnormal change in diabetes, and its associated clinical variables. RESEARCH DESIGN AND METHODS examined 590 participants with diabetes (399 type 1 [T1D] 191 2 [T2D]) 204 control patients without at least year follow-up classified them according rapid corneal loss (RCNFL) if was below 5th...
Purpose.: We examined the age-dependent alterations and longitudinal course of subbasal nerve plexus (SNP) morphology in healthy individuals. Methods.: Laser-scanning corneal confocal microscopy, ocular screening, health metabolic assessment were performed on 64 participants at baseline 12-month intervals for 3 years. At each annual visit, eight central images SNP selected analyzed using a fully-automated analysis system to quantify fiber length (CNFL). Two linear mixed model approaches...
To develop a rapid optimized technique of wide-field imaging the human corneal subbasal nerve plexus. A dynamic fixation target was developed and, coupled with semiautomated tiling software, method capturing and montaging multiple confocal microscopy images created. illustrate utility this technique, maps plexus were produced in 2 participants diabetes, 1 without neuropathy. The montages central 3 mm seem to show general reduction number fibers branches diabetic participant neuropathy...
Purpose.: To investigate longitudinal changes of subbasal nerve plexus (SNP) morphology and its relationship with conventional measures neuropathy in individuals diabetes. Methods.: A cohort 147 type 1 diabetes 60 age-balanced controls underwent detailed assessment clinical metabolic factors, neurologic deficits, quantitative sensory testing, conduction studies, corneal confocal microscopy at baseline four subsequent annual visits. The SNP parameters included fiber density (CNFD), branch...
OBJECTIVE Corneal nerve fiber length (CNFL) has been shown in research studies to identify diabetic peripheral neuropathy (DPN). In this longitudinal diagnostic study, we assessed the ability of CNFL predict development DPN. RESEARCH DESIGN AND METHODS From a multinational cohort 998 participants with type 1 and 2 diabetes, studied subset 261 who were free DPN at baseline completed least 4 years follow-up for incident The predictive validity was determined using time-dependent receiver...
Purpose: To examine the neuronal structural integrity of cornea and retina as markers for degeneration in nonproliferative diabetic retinopathy (NPDR). Methods: Participants were recruited from broader Brisbane community, Queensland, Australia. Two hundred forty-one participants (187 with diabetes 54 nondiabetic controls) examined. Diabetic (DR) was graded according to Early Treatment Retinopathy Study (ETDRS) scale. Corneal nerve fiber length (CNFL), corneal branch density (CNBD),...
Purpose: The aim of this study was to determine alterations the corneal subbasal nerve plexus (SNP) over 4 years using in vivo confocal microscopy participants with type 1 diabetes and identify significant risk factors associated these alterations. Methods: A cohort 108 individuals no evidence peripheral neuropathy at enrollment underwent laser-scanning microscopy, ocular screening, health metabolic assessment baseline, examinations continued for subsequent annual visits. At each visit, 8...