A5091398857- SARS-CoV-2 and COVID-19 Research
- COVID-19 Clinical Research Studies
- vaccines and immunoinformatics approaches
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Influenza Virus Research Studies
- Cell Adhesion Molecules Research
- Cytomegalovirus and herpesvirus research
- Workplace Health and Well-being
- Long-Term Effects of COVID-19
- Vaccine Coverage and Hesitancy
- Neonatal and Maternal Infections
- Burn Injury Management and Outcomes
- Wound Healing and Treatments
- S100 Proteins and Annexins
- Healthcare professionals’ stress and burnout
- Lipid Membrane Structure and Behavior
- Tendon Structure and Treatment
- Diversity and Career in Medicine
- Immune responses and vaccinations
Klinik für Schlafmedizin
2021-2022
University Hospital Münster
2021-2022
University of Münster
2021-2022
Universitätsmedizin Göttingen
2022
University of Aberdeen
2021
Abstract Background Homologous and heterologous SARS‐CoV‐2 vaccinations yield different spike protein‐directed humoral cellular immune responses. This study aimed to explore their currently unknown interdependencies. Methods COV‐ADAPT is a prospective, observational cohort of 417 healthcare workers who received vaccination with homologous ChAdOx1 nCoV‐19, BNT162b2 or nCoV‐19/BNT162b2. We assessed (anti‐spike‐RBD‐IgG, neutralizing antibodies, avidity) (spike‐induced T‐cell interferon‐γ...
Extracorporeal Shock Wave Therapy (ESWT) is used clinically in various disorders including chronic wounds for its pro-angiogenic, proliferative, and anti-inflammatory effects. However, the underlying cellular molecular mechanisms driving therapeutic effects are not well characterized. Macrophages play a key role all aspects of healing their dysfunction results failure to resolve wounds. We investigated ESWT on macrophage activity wound punch biopsies from patients with non-healing venous...
The measures taken to cope with the COVID-19 pandemic by governments worldwide have vast consequences on all areas of life. To assess impact long-term career development, we evaluated work-family balance medical doctors at nine German university clinics. results indicate a severely disturbed balance, which was mostly due insufficient childcare, based restrictions in school operations and childcare. Despite newly created emergency childcare options, aiming ensure functioning "systematically...
Neutrophils are key players of the immune system and possess an arsenal effector functions, including ability to form expel neutrophil extracellular traps (NETs) in a process termed NETosis. During NETosis, nuclear DNA/chromatin expands until it fills whole cell is released into space. NETs composed DNA decorated with histones, proteins, or peptides, NETosis implicated many diseases. Resolving structure nucleus great detail essential understand underlying processes, but so far,...
Background : Homologous and heterologous SARS-CoV-2 vaccinations yield different spike protein-directed humoral cellular immune responses. This study aimed to explore their currently unknown interdependencies. Methods COV-ADAPT is a prospective, observational cohort of 417 healthcare workers who received vaccination with homologous ChAdOx1 nCoV-19, BNT162b2 or nCoV-19/BNT162b2. We assessed (anti-spike-RBD-IgG, neutralizing antibodies, avidity) (spike-induced T cell interferon‑γ release)...
Background: Humoral and cellular immune responses to SARS-CoV-2 vaccines wane with time. In the COV‑ADAPT cohort, we recently studied both immunological components their interdependencies following different vaccine combinations before (T1) up three months after second immunization (T2). This follow-up investigated stability of long-term aimed identify predictive markers. Methods: We assessed humoral (anti-spike-RBD-IgG, neutralization capacity, avidity) (spike-induced T-cell interferon‑γ...
Abstract Neutrophils are key players of the immune system and possess an arsenal effector functions, including ability to form expel neutrophil extracellular traps (NETs) in a process termed NETosis. During NETosis, nuclear DNA/chromatin expands until it fills whole cell is released into space. NETs composed DNA decorated with histones, proteins or peptides NETosis implicated many diseases. Resolving structure dynamics nucleus great detail essential understand underlying processes but so far...
Abstract Background Homologous and heterologous SARS-CoV-2-vaccinations yield different spike protein-directed humoral cellular immune responses. However, their interdependencies remain elusive. Methods COV-ADAPT is a prospective, observational cohort study of 417 healthcare workers who received homologous vaccination with Astra (ChAdOx1-S; AstraZeneca) or BNT (BNT162b2; Biontech/Pfizer) Astra/BNT. We assessed the (anti-spike-RBD-IgG, neutralizing antibodies, antibody avidity) (spike-induced...
Background : Homologous and heterologous SARS-CoV-2 vaccinations yield different spike protein-directed humoral cellular immune responses. This study aimed to explore their currently unknown interdependencies. Methods COV-ADAPT is a prospective, observational cohort of 417 healthcare workers who received vaccination with homologous ChAdOx1 nCoV-19, BNT162b2 or nCoV-19/BNT162b2. We assessed (anti-spike-RBD-IgG, neutralizing antibodies, avidity) (spike-induced T cell interferon‑γ release)...