A5071633508- HIV/AIDS drug development and treatment
- Tuberculosis Research and Epidemiology
- Chemical Synthesis and Analysis
- Advanced Sensor and Energy Harvesting Materials
- Computational Drug Discovery Methods
- Pneumocystis jirovecii pneumonia detection and treatment
- Malaria Research and Control
- Cancer therapeutics and mechanisms
- Analytical Chemistry and Sensors
- RNA and protein synthesis mechanisms
- HIV Research and Treatment
- Microfluidic and Capillary Electrophoresis Applications
- Advanced biosensing and bioanalysis techniques
- Neurological disorders and treatments
- Microfluidic and Bio-sensing Technologies
- Mesoporous Materials and Catalysis
- Protein Degradation and Inhibitors
- Botulinum Toxin and Related Neurological Disorders
- Carbohydrate Chemistry and Synthesis
- Multiple Myeloma Research and Treatments
- Neuroscience and Neural Engineering
- Synthetic Organic Chemistry Methods
- Asymmetric Synthesis and Catalysis
- Synthesis and biological activity
- Diatoms and Algae Research
Ben-Gurion University of the Negev
2022-2024
Central Drug Research Institute
2011-2021
Academy of Scientific and Innovative Research
2015-2019
University of Lucknow
2019
The MNC biosensor is employed for specific and label-free sensing of AFP from 0.5 μL drops diluted serum with a limit-of-detection 10.5 aM dynamic range extending over 6 orders concentration.
In the era of data science, data-driven algorithms have emerged as powerful platforms that can consolidate bioisosteric rules for preferential modifications on small molecules with a common molecular scaffold. Here we present complementary to minimize search in chemical space phenylthiazole-containing bind RNA hairpin within ribosomal peptidyl transferase center (PTC) Mycobacterium tuberculosis. Our results indicate visual, geometrical, and features enhance binding targeted RNA. Functional...
A series of novel 4-aminoquinoline analogues bearing a methyl group at moiety were synthesized via new and robust synthetic route comprising in situ tert-butoxycarbonyl (Boc) deprotection–methylation cascade resulting the corresponding N-methylated secondary amine using Red-Al an efficient microwave-assisted strategy for fusion with 4-chloroquinoline nucleus to access 4-N-methylaminoquinoline analogues. The compounds evaluated their antimalarial activity vitro vivo models. Among 21 tested...
Abstract A simple and stereoselective synthesis of 3‐methylthalidomide, a configurationally stable thalidomide analog, is presented. Herein we describe the ( R )‐3‐methylthalidomide starting from S )‐alanine by piperidin‐2‐one ring assembly approach in high yield enantiomeric purity without using chiral auxiliary or reagent. Starting )‐alanine, corresponding can be prepared same methodology. Chirality 27:619–624, 2015 . © Wiley Periodicals, Inc.
Abstract Tuberculosis is a major cause of mortality worldwide, with drug-resistant strains complicating its treatment. We report the discovery small-molecule inhibitors targeting gyrase Mycobacterium tuberculosis, bacterium responsible for tuberculosis. Gyrase, type II topoisomerase, consists two subunits: GyrA, which breaks and rejoins DNA, GyrB, contains ATPase domain ATP binding hydrolysis. An indole scaffold identified by NMR-fragment screening was grown into drug-sized candidates...
The bottom-up approach exploits simple building blocks to generate new materials with desired physical and chemical characteristics. Here, we combine two routes that occur under mild conditions, self-assembly and...
An expeditious method for the synthesis of homo and heterochiral dipeptides containing l-alanine d/l 2-methyl allo-hydroxyl prolines was developed using direct aminolysis bicyclic lactones derived from alanine. The impact C-2 methylation its spatial orientation on pyrrolidine ring puckering prolyl amide bond configuration ascertained by solution NMR studies. present studies reveal that causes to exist exclusively in trans geometry both homo- dipeptides. However, methyl group i + 2 position...
Botulinum neurotoxins (BoNT) are the most poisonous and lethal substances known to humans, as such there is a great need for fast, easy-to-use, early BoNT detection technologies which not available today. A biosensor based on field-effect transistor (FET) highly pursued sensing platform due inherent low-noise amplification, low-cost, ultimate potential of multiple analytes from an ultra-small sample volume. In current study we employ novel Meta-Nano-Channel (MNC) FET specific label-free...