Malak Almutairi

ORCID: 0000-0001-7759-6437
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About
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Research Areas
  • Metabolism, Diabetes, and Cancer
  • Adipose Tissue and Metabolism
  • Diabetes Treatment and Management
  • COVID-19 Clinical Research Studies
  • Pancreatic function and diabetes
  • Long-Term Effects of COVID-19
  • Dental Health and Care Utilization
  • COVID-19 and Mental Health
  • Diet and metabolism studies
  • Cardiovascular Function and Risk Factors
  • Liver Disease Diagnosis and Treatment
  • Dental Research and COVID-19
  • Impact of Technology on Adolescents
  • Cervical Cancer and HPV Research
  • Pomegranate: compositions and health benefits
  • Receptor Mechanisms and Signaling
  • Dental Anxiety and Anesthesia Techniques
  • Pharmaceutical Economics and Policy
  • Garlic and Onion Studies
  • Indoor Air Quality and Microbial Exposure
  • Biochemical Acid Research Studies
  • COVID-19 Impact on Reproduction
  • Agricultural Practices and Plant Genetics
  • Infectious Encephalopathies and Encephalitis
  • Moringa oleifera research and applications

Armed Forces Hospital
2025

King Saud bin Abdulaziz University for Health Sciences
2016-2024

University of Hafr Al-Batin
2024

Almaarefa University
2020-2023

Saudi Arabian Monetary Authority
2022-2023

Alfaisal University
2020-2023

Qassim University
2019-2022

Princess Nourah bint Abdulrahman University
2021-2022

Ministry of Health
2022

Riyadh Elm University
2022

Abstract The green plant-mediated synthesis of silver (GPS-Ag) nanoparticles (NPs) has been increasingly popular due to its eco-friendliness, availability, cost-effectiveness, and the fact that it can be safely handled possesses a broad variability metabolites, such as antioxidant antimicrobial activities. In this current study, AgNPs demonstrated using aqueous extracts fresh leaves Ficus carica Salvia rosmarinus (rosemary) reduced nitrate. This procedure made NPs possible, which was...

10.1515/gps-2021-0048 article EN cc-by Green Processing and Synthesis 2021-01-01

Pyruvate dehydrogenase (PDH) is the rate-limiting enzyme for glucose oxidation and a critical regulator of metabolic flexibility during fasting to feeding transition. PDH regulated via both kinases (PDHK) phosphatases, which phosphorylate/inactivate dephosphorylate/activate PDH, respectively. Our goal was determine whether transcription factor forkhead box O1 (FoxO1) regulates activity in heart increasing expression Pdk4, gene encoding PDHK4. To address this question, we differentiated H9c2...

10.1152/ajpheart.00191.2017 article EN AJP Heart and Circulatory Physiology 2017-07-08

Background and objectives: Type 2 diabetes mellitus (T2DM) affects brain white matter microstructure. While diffusion tensor imaging (DTI) has been used to study abnormalities in T2DM, it lacks specificity for complex tracts. Neurite orientation dispersion density (NODDI) offers a more specific approach characterising microstructures. This aims explore alterations T2DM using both DTI NODDI assess their association with disease duration glycaemic control, as indicated by HbA1c levels. Methods...

10.3390/medicina61030455 article EN cc-by Medicina 2025-03-06

Obesity and type 2 diabetes (T2D) increase the risk for cardiomyopathy, which is presence of ventricular dysfunction in absence underlying coronary artery disease and/or hypertension. As myocardial energy metabolism altered during obesity/T2D (increased fatty acid oxidation decreased glucose oxidation), we hypothesized that restricting lean mice devoid perturbed metabolic milieu observed would produce a cardiomyopathy phenotype, characterized via diastolic dysfunction. We tested our...

10.3389/fcvm.2018.00017 article EN cc-by Frontiers in Cardiovascular Medicine 2018-03-06

Onion is one of the most widely cultivated high-value vegetables on globe. The study variability and genetic divergence in this crop will facilitate judicious parent selection for future breeding. present incorporated 20 onion genotypes to determine diversity through morpho-physiological molecular markers. were tested two consecutive years effects yield-attributing bulb-quality traits. Diversity at a level with 31 simple sequence repeat (SSR) markers was determined. Adequate existed among...

10.3390/su14031131 article EN Sustainability 2022-01-19

Discharge instructions are vital in postemergency patient care to help the caregiver understand diagnosis and identify symptoms which require prompt readmission. In general, oral or written provided on discharge. However, there is a dearth of information efficacy discharge by physicians KSA.To evaluate for postpediatrics emergency visit.This observational cross-sectional survey conducted Department Paediatric Emergency at King Abdul Aziz Medical City, Riyadh, KSA, included 173 literate adult...

10.4103/2230-8229.189128 article EN Journal of Family and Community Medicine 2016-01-01

Type-1 diabetes (T1D) is an autoimmune disorder characterized by impaired insulin release islet β cells. It has been shown that proinflammatory cytokines released during the disease can exacerbate condition, while anti-inflammatory offer protection. This study analyzed clinical role of interleukin (IL)-6, -8, -10, and vitamin D levels in T1D patients compared to healthy controls. The IL-6, IL-8, IL-10, participants' serum samples were using ELISA. findings showed had significantly increased...

10.1038/s41598-024-73737-6 article EN cc-by-nc-nd Scientific Reports 2024-10-16

The uncertainty about COVID-19 outcomes in angiotensin-converting enzyme inhibitors (ACEI)/angiotensin receptor blockers (ARB) users continues with contradictory findings. This study aimed to determine the effect of ACEI/ARB use patients severe COVID-19. retrospective cohort was done two Saudi public specialty hospitals designated as referral facilities. We included 354 a confirmed diagnosis between April and June 2020, which 146 were 208 non-ACEI/ARB users. Controlling for confounders, we...

10.1016/j.jiph.2021.03.004 article EN cc-by-nc-nd Journal of Infection and Public Health 2021-03-23

Anaphylaxis is a common emergency and life-threatening hypersensitivity reaction defined as rapid generalized allergic reaction. Prior international studies have shown that school personnel often not familiar with the signs of or appropriate management strategies should be initiated at for children an anaphylactic Moreover, no evaluated awareness anaphylaxis by teachers in Saudi Arabia. The aim this study was to determine teachers' knowledge, attitudes, practices toward Al-Qassim,...

10.4103/jfmpc.jfmpc_562_19 article EN cc-by-nc-sa Journal of Family Medicine and Primary Care 2019-01-01

Obese individuals are often at risk for nonalcoholic fatty liver disease (NAFLD), insulin resistance, type 2 diabetes (T2D), and cardiovascular diseases such as angina, thereby requiring combination therapies their comorbidities. Ranolazine is a second-line antianginal agent that also improves glycemia, our aim was to determine whether ranolazine modifies the progression of obesity-induced NAFLD. Twelve-week-old C57BL/6J male mice were fed low-fat or high-fat diet 10 weeks then treated 30...

10.1172/jci.insight.124643 article EN JCI Insight 2019-01-10

We aimed to evaluate the cost effectiveness of Favipiravir treatment versus standard care (SC) in moderately severely ill COVID-19 patients from Saudi healthcare payer perspective.

10.1016/j.jsps.2023.02.003 article EN cc-by-nc-nd Saudi Pharmaceutical Journal 2023-02-15

The introduction of direct-acting antivirals (DAA) to treat the hepatitis C virus (HCV) overcame many drawbacks interferon-based therapy. DAA achieved sustained viral response (SVR) rates above 90% and pegylated interferon regimens.The HCV genotype (GT) distribution varies by geographical area, with GT-4 being most prevalent in Middle East region, including Saudi Arabia. Yet, real-world evidence about using DAAs population is limited.Thus, aim this study investigate effectiveness safety...

10.1016/j.jsps.2022.07.005 article EN cc-by Saudi Pharmaceutical Journal 2022-07-25

Missing teeth are routinely replaced with fixed dental prostheses (FDPs); thus, knowing the patient's oral health-related quality of life (OHRQoL) after placement FDP and factors affecting their in addition to hygiene practices is important. This study aimed measure OHRQoL FDPs adults Riyadh, Saudi Arabia.A survey was distributed hard soft copy forms. Target subjects were older than 18 years living Riyadh. The questionnaire contained four domains: demographic data, medical history,...

10.4103/jispcd.jispcd_347_19 article EN Journal of International Society of Preventive and Community Dentistry 2020-01-01

Abstract Glycerol, flavorings and sweeteners constitute approximately 70% of water-pipe tobacco smoking (WTS) mixtures. Tobacco mixture combustion produces smoke toxins (e.g. carbonyl compounds), which the type amount are highly dependable on formula. While glycerol in contribute to enhanced experience, its’ toxicants such as acrolein. According WHO, there no approved international upper limits regulations WTS ingredients. This study aims assess toxicant emission levels corresponding...

10.1186/s12889-023-16740-2 article EN cc-by BMC Public Health 2023-09-25

Silver diamine fluoride (SDF) has been accepted as an appropriate alternative for caries management. However, knowledge and utilization of SDF among dentists vary considerably. The authors in the present study aimed to assess awareness, knowledge, attitudes, use general (GD) Saudi Arabia correlate differences based on different regions experience levels dentists. In this regard, a cross-sectional web-based questionnaire was conducted, response received from 311 GDs parts country. Information...

10.3390/healthcare10112161 article EN Healthcare 2022-10-29

Objective: Growing epidemics of type-2 diabetes mellitus (T2DM) and obesity have become a serious health concern. Since miRNAs vitamin levels affect the development progression numerous pathogenic diseases, including diabetes, present study aimed to evaluate miRNA-143 miRNA-145 expression vitamin-D status among obese non-obese T2DM patients. Methods: The included 100 clinically confirmed newly diagnosed cases healthy subjects. Total RNA was extracted from collected blood samples ng used for...

10.2147/jmdh.s391996 article EN cc-by-nc Journal of Multidisciplinary Healthcare 2022-12-01
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