A5078491462- T-cell and B-cell Immunology
- Immunotherapy and Immune Responses
- Multiple Sclerosis Research Studies
- Systemic Lupus Erythematosus Research
- Ergonomics and Musculoskeletal Disorders
- Ocular and Laser Science Research
- Synthetic Aperture Radar (SAR) Applications and Techniques
- Satellite Image Processing and Photogrammetry
- Viral Infections and Immunology Research
- Geophysics and Gravity Measurements
- Cancer-related gene regulation
- Planetary Science and Exploration
- Occupational and environmental lung diseases
- Renal and related cancers
- Retinoids in leukemia and cellular processes
- Global Healthcare and Medical Tourism
- T-cell and Retrovirus Studies
- Public health and occupational medicine
- Occupational health in dentistry
- Patient Dignity and Privacy
- Drug-Induced Ocular Toxicity
- Digital Imaging in Medicine
- Medical and Biological Sciences
- Wnt/β-catenin signaling in development and cancer
- Medicinal plant effects and applications
Université Libre de Bruxelles
1997-2004
Transnational University Limburg
1998-2003
Stanford University
2002
Abstract Wnt-induced β-catenin-mediated transcription is a driving force for stem cell self-renewal during adult tissue homeostasis. Enhanced Wnt receptor expression due to mutational inactivation of the ubiquitin ligases RNF43 / ZNRF3 recently emerged as leading cause cancer development. Consequently, targeting canonical receptors such LRP5/6 holds great promise treatment subsets. Here, we employ CIS display technology identify single-domain antibody fragments (VHH) that bind LRP6 P3E3P4E4...
Abstract Myelin basic protein (MBP)‐reactive T cells have been implicated in the autoimmune pathogenesis of multiple sclerosis (MS). In this study, we examined cytokine profile 531 primary MBP‐reactive T‐cell lines and 72 independently established clones from 32 patients with MS 18 healthy controls (NS) by using highly sensitive enzyme‐linked immunosorbent assays. An increased number producing interferon‐γ (IFNγ) and/or interleukin‐4 (IL‐4) response to MBP were found compared controls. No...