A5007335585- Computational Drug Discovery Methods
- Synthesis and biological activity
- Analytical Chemistry and Chromatography
- Eicosanoids and Hypertension Pharmacology
- Synthesis of heterocyclic compounds
- Synthesis and Characterization of Heterocyclic Compounds
- Chemical Synthesis and Analysis
- Chemical Reaction Mechanisms
- Organic and Inorganic Chemical Reactions
- Radiopharmaceutical Chemistry and Applications
- Bioactive Compounds and Antitumor Agents
- Multicomponent Synthesis of Heterocycles
- Advances in Cucurbitaceae Research
- Pharmacological Effects of Natural Compounds
- Natural Antidiabetic Agents Studies
- Psidium guajava Extracts and Applications
- Diet, Metabolism, and Disease
- Various Chemistry Research Topics
- Steroid Chemistry and Biochemistry
- Pharmacogenetics and Drug Metabolism
- Sulfur Compounds in Biology
- Phytochemicals and Antioxidant Activities
- Peroxisome Proliferator-Activated Receptors
- Drug-Induced Hepatotoxicity and Protection
- Spacecraft Dynamics and Control
Hawler Medical University
2017-2024
University of Kurdistan Hewler
2024
Cardiff University
2017-2019
Background and objective: Isoxazoles are significant heterocyclic products that used in various applications the field of medicinal chemistry. Along with prescription drugs, a variety bioactive pharmaceutical substances, such as valdecoxib, leflunomide, danazol, include isoxazole core. The present work aimed to synthesize test antibacterial, antioxidant, antifungal activities combined theoretical investigations. Methods: Various 2,4-disubstituted isoxazoles have been synthesized through...
Abstract In recent times, the methods used to evaluate gastric ulcer healing worldwide have been based on visual examinations and estimating dimensions in experimental animals. this study, protective effect of rhodanine 2,4-thiazolidinediones scaffolds compared esomeprazole was investigated an ethanol model stomach ulcers rats. Pretreatment with treatments or prevented development ethanol-induced ulcers. The severity lesions injuries significantly lower than that vehicle (10% Tween 80)...
Methanolic extract from Onopordum acanthium L. leaves (MEOAL) has been discovered to treat diabetic complications. The objective of this study is evaluate the ameliorative role MEOAL on pancreatic islet injury and myocardial inflammation in rats.Forty male Wister albino rats were allocated into five groups eight each. Group A was negative control group. Single intraperitoneal injection streptozocin (50mg/kg) used for four experimental groups. B served as positive Groups C, D, E received...
In the present study, hepatoprotective effect of 5-benzylidine-2-thiohydantoin (5B2T), a unique derivative thiohydantoin group, on liver injury induced by diethylnitrosamine (DEN) in male rats was investigated. The experimental animals were divided into three groups, each with 14 rats. Rats group I considered to be controls and received only 10% Tween 80. II injected 200 mg/kg DEN intraperitoneally. III single dose intraperitoneally treatment orally (50 mg/kg, 5B2T) for two durations, 3 6...
Racemization has a large impact upon the biological properties of molecules but chemical scope compounds with known rate constants for racemization in aqueous conditions was hitherto limited. To address this remarkable blind spot, we have measured kinetics 28 using circular dichroism and 1 H NMR spectroscopy. We show that (measured by ourselves others) correlate well deprotonation energies from quantum mechanical (QM) group contribution calculations. Such calculations thus provide...
Background and objective: Compounds having imine or azomethine (–C=N–) functional group are known as Schiff bases. bases compounds found to be an active pharmacophore for the design development of various bioactive lead compounds. In this study, several new base have been synthesized characterized. Methods: Williamson ether synthesis process has used synthesize -alkyloxy substituted benzyloxy benzaldehyde. Differently benzaldehydes react with...
Abstract Racemization has a large impact upon the biological properties of molecules but chemical scope compounds with known rate constants for racemization in aqueous conditions was hitherto limited. To address this remarkable blind spot, we have measured kinetics 28 using circular dichroism and 1 H NMR spectroscopy. We show that (measured by ourselves others) correlate well deprotonation energies from quantum mechanical (QM) group contribution calculations. Such calculations thus provide...
Fumaria officinalis which belong to the Papaveraceae family is used treat stomach-related ailments in Iraqi folk medicine. The aim of this study was determine anti-ulcer and antioxidant activities a 70% ethanol extract F. officinalis. Extracts aerial parts at doses 200 400 mg/kg body weight standard drug, esomeprazole dose 20 were orally administered daily for 21 days after ulcer induction. rats sacrificed, their stomachs subjected macroscopic microscopic studies. ethanolic showed...
The hepatoprotective effect of synthesized 3-(3,5-bis (trifluoromethyl) phenyl)-5-methyl-1-((1-methyl-1H-pyrrol-2-yl) methyl)-2-thioxoimidazolidin-4-one (3FL-M) was evaluated against diethyl nitrosamine-induced liver injury (DEN). Wistar rats were divided into 3 groups as: placebo (received 10% tween 80%), hepatotoxic control (injected with 200 mg/kg DEN) and treatment DEN received 50 oral feeding the 3FL-M). Half number sacrificed on 2nd week experiment, whereas other half after 6 weeks....
The title compounds with different optically active substituted ester of hydantoic and thiohydantoic were synthesized by the reaction corresponding enantio-pure amino acids methyl hydrochloride phenylisocyanate/thiocyanate in presence triethylamine. duration was limited to avoid racemisation produce high enantio-enriched compounds. Low values ELUMO-HOMO gap 0.14, 0.16, 0.15, 0.10 eV observed for 1, 2, 3, 4, 5, respectively indicate soft, reactivity Values also show that can easily decompose...
Abstract The authors have requested that this preprint be removed from Research Square.