A5004103514- Cancer Immunotherapy and Biomarkers
- Single-cell and spatial transcriptomics
- CAR-T cell therapy research
- Renal cell carcinoma treatment
- Cancer Genomics and Diagnostics
- Child and Adolescent Health
- Immune cells in cancer
- Cardiac Arrhythmias and Treatments
- Ethics and Legal Issues in Pediatric Healthcare
- Venous Thromboembolism Diagnosis and Management
- Immune Cell Function and Interaction
- Autoimmune Neurological Disorders and Treatments
- Neurological Complications and Syndromes
- Immunotherapy and Immune Responses
- Migration, Health and Trauma
- Atrial Fibrillation Management and Outcomes
- Cerebral Venous Sinus Thrombosis
Yale University
2023-2025
University Hospital Heidelberg
2021
Heidelberg University
2021
Queen's Hospital
2010
Abstract Immune checkpoint inhibitors (ICI) targeting the PD-1 pathway have transformed treatment of advanced renal cell carcinoma (RCC), but mechanisms underlying therapeutic response remain largely unknown. Herein, we perform transcriptomic analysis on RCC biospecimens from 102 patients enrolled in a phase II clinical trial frontline nivolumab (NCT03117309) to investigate determinants anti-PD1 monotherapy. Through bulk analysis, identify an enrichment genes associated with tertiary...
Nontraumatic haemarthrosis secondary to anticoagulant therapy is a recognized clinical problem. The involved joints are usually large weight-bearing joints, particularly the knee. We describe case of spontaneous in 53-year-old female patient, who had been started on drugs after pulmonary embolism past (international normalized ratio admission: 2.4). patient presented with acute onset severe shoulder pain no history trauma. Her showed radiological signs anterior dislocation. Attempts relocate...
Abstract Despite the success of immune-checkpoint inhibitors (ICI) for treatment renal cell carcinoma (RCC), many patients fail to receive durable clinical benefits. Therefore, an understanding resistance ICIs in RCC is critical this disease. Through single-cell transcriptomic analysis patient T cells HCRN GU16-260 trial, we previously identified a population CD8+ expressing SLAMF7 immune receptor that was associated with nivolumab monotherapy. Here, functionally interrogated impact...
Abstract The diversity of T cell receptors (TCRs) becomes increasingly restricted with advancing stage in renal carcinoma (RCC), individual clones becoming dramatically expanded. Further, prior studies have suggested that TCR clonality (i.e. less diversity) could be associated improved clinical response to anti-PD-1 treatment. To further interrogate the landscape advanced RCC and its relation both phenotype outcomes, single-cell sequencing (scTCR-seq) was performed parallel RNA (scRNA-seq)...
<h3>Background</h3> Renal cell carcinoma (RCC) is an immunologically paradoxical tumor. Despite high T infiltration, increased CD8+ cells are not associated with response to programmed death 1 (PD-1) blockade.<sup>1</sup> Through single-cell transcriptomic analysis, we previously identified a population of SLAMF7+ exhausted that was resistance nivolumab monotherapy in the HCRN GU16–260 trial (NCT03117309) (Braun, ASCO, 2023). In present study, generated gene expression signature (GES)...
<h3>Background</h3> Despite the transformative impact of current immune checkpoint inhibitors (ICIs) targeting PD-1 and CTLA-4 pathways on management advanced renal cell carcinoma (RCC), many patients still do not receive long-term benefit often suffer from adverse events. Therefore, we aim to validate efficacy novel immunomodulatory therapies by focusing functional assessment T cells inhibiting T-cell immunoreceptor with Ig ITIM domains (TIGIT). In this study, established an...
Thunderclap headache is frequently associated with serious intracranial vascular disorders and a usual reason for emergency department admissions. Association of thunderclap headaches autoimmune disorders, such as steroid-responsive encephalopathy thyroiditis (SREAT), highly unusual. Here, we report patient who presented high-intensity abrupt onset. Cerebrospinal fluid (CSF) analysis revealed moderate lymphocytic pleocytosis without evidence infectious, neoplastic, or metabolic causes. Brain...