A5075160435- Catalytic Cross-Coupling Reactions
- Catalytic C–H Functionalization Methods
- Organoboron and organosilicon chemistry
- Fluorine in Organic Chemistry
- Asymmetric Synthesis and Catalysis
- Metal-Organic Frameworks: Synthesis and Applications
- Inorganic Fluorides and Related Compounds
- Supramolecular Chemistry and Complexes
- Chemical Synthesis and Analysis
- Synthesis and Reactions of Organic Compounds
- Radical Photochemical Reactions
- Molecular Sensors and Ion Detection
The University of Tokyo
2024
RWTH Aachen University
2017-2019
Mahidol University
2015-2016
A ligand-controlled and site-selective nickel catalyzed Suzuki–Miyaura cross-coupling reaction with aromatic esters alkyl organoboron reagents as coupling partners was developed. This methodology provides a facile route for C(sp2)–C(sp3) bond formation in straightforward fashion by successful suppression of the undesired β-hydride elimination process. By simply switching phosphorus ligand, ester substrates are converted into alkylated arenes ketone products, respectively. The utility this...
Abstract Transition-metal-catalyzed cross-couplings have been extensively used in the pharmaceutical and agrochemical industries for construction of diverse C–C bonds. Conventional cross-coupling reactions require reactive electrophilic coupling partners, such as organohalides or sulfonates, which are not environmentally friendly naturally abundant. Another disadvantage associated with these transformations is need an exogenous base to facilitate key transmetalation step, this reagent...
A nickel-catalyzed deamidative cross-coupling reaction of amides with terminal alkynes as coupling partners was disclosed. This newly developed methodology allows the direct interconversion to and enables a facile route for C(sp2)–C(sp) bond formation in straightforward mild fashion.
An unprecedented nickel-catalyzed decarbonylative silylation via CO extrusion intramolecular recombination fragment coupling of unstrained and nondirecting group-assisted silyl ketones is described. The inexpensive readily available catalyst performs under mild reaction conditions enables the synthesis structurally diverse arylsilanes, including heterocyclic natural product derivatives.
A new chiral UiO-type MOF with scandium tris(dodecyl sulfate) showed superior catalytic performance to the usual micellar catalysis in presence of proteins, demonstrating ability prevent active Lewis acid sites from mortiferous deactivation.
Nickel-catalyzed ipso-borylations and silylations of aldehydes are described for the first time. The new functional-group interconversion protocol is characterized by its scalability, tolerance wide substrate scope, including examples late-stage functionalization complex molecules. key successful reaction outcome use a ketone as hydride acceptor that intercepts nickel to undergo reductive pathway, thus allowing formation desired C-B C-Si bonds.
A general synthetic strategy to cis-fused bicyclic γ-butyrolactones via the retro-Diels–Alder reaction/intramolecular conjugate ene cascade (RDA/ICE) reaction under flash-vacuum pyrolysis of maleic anhydride adducts is developed. The gave high yields products with stereoselectivity. existence difluoromethyl or trifluoromethyl group at γ-position in situ-generated homoalkenyl- homoalkynyl-α,β-unsaturated was found accelerate rate intramolecular leading γ-difluoromethylated and...
Abstract A general strategy leading to cis‐fused bicyclic γ‐butyrolactones via retro‐Diels‐Alder reaction/intramolecular conjugate ene cascade reaction using flash‐vacuum pyrolysis of maleic anhydride adducts is developed.