A5051548997- Immune Response and Inflammation
- Dermatology and Skin Diseases
- T-cell and B-cell Immunology
- Immune Cell Function and Interaction
- Inflammasome and immune disorders
- IL-33, ST2, and ILC Pathways
- Immunotherapy and Immune Responses
- Respiratory and Cough-Related Research
- Gut microbiota and health
- Wound Healing and Treatments
- Asthma and respiratory diseases
- Pediatric health and respiratory diseases
University of California, San Francisco
2019-2023
23andMe (United States)
2022
Resident microbes in skin and gut predominantly impact local immune cell function during homeostasis. However, colitis-associated neutrophilic disorders suggest possible breakdown of this compartmentalization with disease. Using a model wherein neonatal colonization by Staphylococcus epidermidis facilitates generation commensal-specific tolerance CD4+ regulatory T cells (Tregs), we ask whether response is perturbed inflammation. Chemically induced colitis accompanied intestinal expansion S....
Abstract Early life microbe-immune interactions at barrier surfaces have lasting impacts on the trajectory towards health versus disease. Monocytes, macrophages and dendritic cells are primary sentinels in tissues, yet salient contributions of commensal-myeloid crosstalk during tissue development remain poorly understood. Here, we identify that commensal microbes facilitate accumulation a population monocytes neonatal skin. Transient postnatal depletion these resulted heightened IL-17A...
Summary Early life establishment of tolerance to commensal bacteria at barrier surfaces carries enduring implications for immune health but remains poorly understood. Here we show that this process is controlled by microbial interaction with a specialized subset antigen presenting cells. More particularly, identify CD301b + type 2 conventional dendritic cells (DC) as in neonatal skin specifically capable uptake, presentation and generation regulatory T (Tregs) antigens. In early life, DC2...
The gut and skin are major barrier tissues that house microbial communities capable of influencing host immunity. Under homeostatic conditions, resident microbes at each these two sites thought to have a dominant impact on local immune cell function. However, the prevalence neutrophilic disorders among patients with Inflammatory Bowel Disease suggests this compartmentalized control may not hold under disease conditions. We hypothesized an altered response gut-resident during colitis...
Abstract Both gut and skin house microbial communities capable of influencing host immunity. During homeostasis, resident microbes are thought to have a dominant impact on local immune cell function. However, the prevalence disorders among IBD patients suggests that this compartmentalized control may not hold under disease conditions. We hypothesize an altered response gut-resident during colitis facilitate excessive inflammation directed at commensals. Our lab has previously shown...