A5032123166- Advanced Breast Cancer Therapies
- Pharmacovigilance and Adverse Drug Reactions
- Cancer Immunotherapy and Biomarkers
- Breast Cancer Treatment Studies
- Lung Cancer Treatments and Mutations
- Cancer Treatment and Pharmacology
- Drug-Induced Adverse Reactions
- Lymphoma Diagnosis and Treatment
- Head and Neck Cancer Studies
- Pharmacological Effects and Toxicity Studies
- Cancer Diagnosis and Treatment
- Chemotherapy-related skin toxicity
- Cancer Genomics and Diagnostics
- Pharmaceutical Economics and Policy
- Lung Cancer Research Studies
- Colorectal Cancer Treatments and Studies
- Melanoma and MAPK Pathways
- Bone and Joint Diseases
- Bone health and treatments
- Patient Safety and Medication Errors
- Head and Neck Surgical Oncology
- Salivary Gland Tumors Diagnosis and Treatment
- Breast Lesions and Carcinomas
- Statistical Methods in Clinical Trials
- Radiomics and Machine Learning in Medical Imaging
Sparsh Hospital
2023
HCG Cancer Hospital
2023
Healthcare Global Enterprises
2019-2021
Broad Institute
2019
Dana-Farber Cancer Institute
2019
Roswell Park Comprehensive Cancer Center
2009
University of Nebraska Medical Center
2009
The genetic profiling of non-small cell lung cancer (NSCLC) has contributed to the discovery actionable targetable mutations, which have significantly improved outcomes in disease with poor prognosis. Molecular epidemiological data driver mutations Indian populations not been extensively elaborated compared western and eastern Asian NSCLC populations. This study assessed prevalence clinical EGFR (epidermal growth factor receptor) among cohort South India.Retrospective analysis 2,003 patients...
Induction docetaxel, cisplatin, and 5-fluorouracil (TPF) chemotherapy followed by definitive concurrent chemoradiation remains the standard of care in locally advanced squamous cell carcinoma head neck cancers despite which survival low. So, we analyzed efficacy adverse effect profile addition nimotuzumab to TPF induction chemotherapy. Methods. We included 20 patients with neck. Patients were administered plus (TPF + N) carboplatin. Treatment responses assessed PET-CT following...
1078 Background: Androgen receptor (AR) expressing triple negative breast cancer (TNBC) is a sub-set of TNBC with an evolving prognostic and predictive behaviour. AR immunohistochemical threshold for positivity has not been standardized wide range cut-offs have used across studies ( > 0% to 75%). In this study we explored immunohistochemistry thresholds in relation disease free survival (DFS) clinical outcomes non-metastatic using the Allred H-Score systems. Increasing interest as...
Abstract Background: Approximately 5-10% of newly diagnosed breast cancers (BC) are de novo MBC, which means that metastatic disease was identified at the time initial diagnosis. Patients with MBC underrepresented in currently available genomic studies. In The Cancer Genome Atlas (TCGA) dataset, only 15 out ˜980 BC patients can be classified as having MBC. objective this study is to analyze landscape and differences cohort early stage BC. To enhance our ability we utilized data from...
e12579 Background: Metaplastic breast carcinoma is a rare histological subtype that has basal like characteristics and reported to have poorer prognosis than no specific type/ductal (ductal/NST). We aimed investigate clinicopathological features outcome from single institution based registry. Methods: Clinical records of cancer patients treated during 2012-2019 were screened 31 cases metaplastic found. Descriptive analysis was done for patients’ demographics features. Kaplan Meier method...
Ogilvie syndrome or intestinal pseudo-obstruction is a clinical characterized by autonomic imbalance affecting peristalsis of colon leading to obstructive signs and symptoms. The etiologies commonly implicated are drugs the cholinergic system, narcotics, electrolyte imbalance, severe sepsis, cancer, major surgery, renal cardiac failure. secondary chemotherapy very rare phenomenon with few reports in literature. Cisplatin-induced neuropathy has been reported occur when cumulative dose exceeds...
e16269 Background: Combination of Gem+Nab-P is considered as a dose intense regimen which exhibits synergistic cytotoxic activity and equally effective in increasing survival FOLFIRINOX pancreatic cancer. However, number patients who tolerates such found to be less Indian population. The importance maintaining optimum RDI well-known however low may reflect poor tolerability. Therefore, the present study aimed identify desired relative intensity explore potential baseline NLR prognostic...
e16531 Background: DOC at 30 mg/m 2 q wk for 3 wks 4 was modestly active and minimized toxicity in patients (pts) with platinum resistant epithelial ovarian cancer compared to historical data of 75 to100 21 days (Berkenblit, Gynecologic Oncology 2004). However, the optimal schedule weekly pts has not been determined. Our study assessed activity safety 36 6 8 paclitaxel cancer. PK PD studies were performed on 1 6. Methods: Pts (n = 25) up previous treatments eligible. administered IV over min...
e15522 Background: Taxanes are an integral part of chemotherapy for a broad range tumor types. The usual toxicities associated with Taxane use peripheral neuropathy, myelosuppression and musculoskeletal adverse effects. Very few studies have reported taxane induced pulmonary toxicity objectively. In our study we explored based on discrete CT findings. Methods: 40 non-smokers diagnosed Her-2 negative breast cancer who received monotherapy from 2017 to 2018 were retrospectively analyzed pre...
e15020 Background: Neutrophil-Lymphocyte Ratio (NLR) and Lymphocyte-Monocyte (LMR) have been under scrutiny for their potential as a prognostic tool in various cancers. While there conflicting opinions on reliability, NLR has shown rather near accurate predictions previous studies. Targeted tyrosine kinase inhibitors good results improving OS PFS of patients with EGFR-mutated NSCLC but the indicators are limited. This study aims to decipher if baseline LMR ratios valid tools predict...
e12570 Background: Gene expression profiling for breast cancer has classified ER positive subtype into luminal A and B. Luminal B (LBBC) have a higher proliferation poorer prognosis than tumors. Ki-67 index is the commonly used marker in cancer; however Ki67 can also be to identify subset of patients among LB with favorable prognosis. This study attempts verify this LBBC based on DFS PFS non-metastatic metastatic respectively. Methods: We retrospectively analyzed 80 IDC diagnosed 2013-2016...
e18802 Background: SAR, a known adverse event of cancer therapy has variable severity. Despite the availability many approved grading tools, there is still lack globally applicable system. To address this, World Allergy Organization (WAO) created uniform 5-grade classification system which was modified recently to be for all SAR’s. This study aims understand incidence and severity chemotherapy induced SAR overall response rate (ORR) rechallenged drugs in tertiary center. Methods: A...