A5077362667- Genetics and Neurodevelopmental Disorders
- Ubiquitin and proteasome pathways
- Educational Innovations and Technology
- RNA modifications and cancer
- Innovative Teaching Methods
- Autism Spectrum Disorder Research
- Educational Games and Gamification
- Communication and COVID-19 Impact
- RNA Research and Splicing
- Educational Research and Science Teaching
- Mobile Learning in Education
- E-Learning and Knowledge Management
- Neurological disorders and treatments
- Congenital heart defects research
- Cancer-related Molecular Pathways
- Genetic Neurodegenerative Diseases
- Plant Stress Responses and Tolerance
- interferon and immune responses
- Agriculture and Social Issues
- Plant tissue culture and regeneration
- Ion channel regulation and function
- Seed Germination and Physiology
- Cooperative Studies and Economics
- ATP Synthase and ATPases Research
- Plant and soil sciences
Universidad Internacional De La Rioja
2019-2024
Université Côte d'Azur
2019-2022
Centre National de la Recherche Scientifique
2018-2022
Institut de Pharmacologie Moléculaire et Cellulaire
2018-2022
Nuestras Raices
2022
Infant
2022
Universidad de La Rioja
2018
Universitat Pompeu Fabra
2015
One of the main objectives in education is to increase motivation students achieve meaningful learning. The use technologies classrooms which are familiarized with such as smartphone or tablet, a way this goal. On other hand, it has been proven that inclusion scenarios supported by games and competition enhance active participation students. Therefore, work we present results study based on application Kahoot secondary education, subjects mathematics, biology & geology physics chemistry,...
Fragile X syndrome (FXS) is the most frequent inherited cause of intellectual disability and best-studied monogenic autism. FXS results from functional absence fragile mental retardation protein (FMRP) leading to abnormal pruning consequently synaptic communication defects. Here we show that FMRP a substrate small ubiquitin-like modifier (SUMO) pathway in brain identify its active SUMO sites. We unravel consequences sumoylation neurons by combining molecular replacement strategy, biochemical...
Abstract Fragile X syndrome (FXS) is the most frequent form of inherited intellectual disability and best-described monogenic cause autism. CGG-repeat expansion in FMR1 gene leads to silencing, loss-of-expression Mental Retardation Protein (FMRP), a common FXS. Missense mutations were also identified FXS patients, including recurrent FMRP-R138Q mutation. To investigate mechanisms underlying caused by this mutation, we generated knock-in mouse model ( Fmr1 R138Q ) expressing protein. We...
Mutations in the CACNA1A gene, encoding pore-forming CaV2.1 (P/Q-type) channel α1A subunit, result heterogeneous human neurological disorders, including familial and sporadic hemiplegic migraine along with episodic progressive forms of ataxia. Hemiplegic Migraine (HM) mutations induce gain-of-channel function, mainly by shifting activation to lower voltages, whereas ataxia mostly produce loss-of-channel function. However, some HM-linked gain-of-function are also associated congenital and/or...
SUMOylation is a post-translational modification essential to cell homeostasis. A tightly controlled equilibrium between and deSUMOylation processes also critical the neuronal function including neurotransmitter release synaptic transmission plasticity. Disruption of homeostasis in neurons associated with several neurological disorders. The balance substrate proteins maintained by group enzymes called SENPs. We previously showed that activation type 5 metabotropic glutamate receptors...
Cooperative learning is an active methodology where students, in small groups, carry out activities a coordinated manner to achieve common objective. Over the years it has been proven that increases students' performance, increasing their self-esteem and improving social skills. One of key elements best results implementation methodology, which includes formation teams. Through systematic review, following PRISMA statement, latest advances made this regard are analyzed. The importance team...
Las características propias de nuestra sociedad, altamente tecnificada, traen consigo la necesidad que los ciudadanos sean capaces responder ante diferentes situaciones su día a utilizando conocimientos tipo matemático, desde edades tempranas. El cambio forzoso una educación on-line dado durante el año 2020 y provocado por virus SARS-Cov2 ha reflejado esta necesidad, puede verse compensada con un adecuado uso las Tecnologías Información Comunicación (TIC) en procesos enseñanza-aprendizaje...
La sociedad actual está ampliamente influenciada por los grandes adelantos científicos y tecnológicos que se han desarrollado desde el siglo pasado. Esto implica la ciudadanía enfrenta diariamente a situaciones problemáticas requieren puesta en marcha de competencias científicas, estableciendo importancia del desarrollo alfabetización científica, permite reflexión, razonamiento establecimiento conexiones para resolverlas manera satisfactoria. En este sentido, trabajos tipo práctico suponen...
Abstract Fragile X syndrome (FXS) is the most frequent form of inherited intellectual disability and best-described monogenic cause autism. FXS usually caused by a CGG-repeat expansion in FMR1 gene leading to its silencing loss-of-expression Mental Retardation Protein (FMRP). Missense mutations were also identified patients, including recurrent FMRP-R138Q mutation. To investigate mechanisms underlying these we generated knock-in mouse model (Fmr1 R138Q ) expressing protein. We demonstrate...