A5040255044- Antibiotic Resistance in Bacteria
- Bacterial biofilms and quorum sensing
- Vibrio bacteria research studies
- Bacterial Genetics and Biotechnology
- Legionella and Acanthamoeba research
- Bacteriophages and microbial interactions
- Antimicrobial Peptides and Activities
- bioluminescence and chemiluminescence research
- Theology and Philosophy of Evil
- Salmonella and Campylobacter epidemiology
- Chemical Reactions and Isotopes
- Classical Philosophy and Thought
- Ocular and Laser Science Research
- Ocular Surface and Contact Lens
- Laser Applications in Dentistry and Medicine
- Medieval Philosophy and Theology
Université de Bourgogne
2018-2021
Centre National de la Recherche Scientifique
2017-2021
Université Bourgogne Franche-Comté
2017-2021
Laboratoire Chrono-Environnement
2016-2017
Université de franche-comté
2016
ABSTRACT Multidrug-resistant mutants of Pseudomonas aeruginosa that overproduce the active efflux system MexEF-OprN (called nfxC mutants) have rarely been characterized in hospital setting. Screening 221 clinical strains exhibiting a reduced susceptibility to ciprofloxacin (a substrate MexEF-OprN) and imipenem negatively coregulated porin OprD) led identification 43 (19.5%) mutants. Subsequent analysis 22 nonredundant showed that, contrast their vitro -selected counterparts, only 3 them...
ABSTRACT The multidrug efflux system MexEF-OprN is produced at low levels in wild-type strains of Pseudomonas aeruginosa . However, so-called nfxC mutants, mutational alteration the gene mexS results constitutive overexpression pump, along with increased resistance bacterium to chloramphenicol, fluoroquinolones, and trimethoprim. In this study, analysis vitro -selected chloramphenicol-resistant clones strain PA14 led identification a new class MexEF-OprN-overproducing mutants (called nfxC2 )...
ABSTRACT When overproduced, the multidrug efflux system MexEF-OprN increases resistance of Pseudomonas aeruginosa to fluoroquinolones, chloramphenicol, and trimethoprim. In this work, we demonstrate that gain-of-function mutations in regulatory gene mexT result oligomerization LysR regulator MexT, constitutive upregulation pump, increased clinical isolates.
NOSO-502 is a preclinical antibiotic candidate of the odilorhabdin class. This compound exhibits activity against Enterobacteriaceae pathogens, including carbapenemase-producing bacteria and most colistin (CST)-resistant strains.
The biological features that allow a pathogen to survive in the hospital environment are mostly unknown. extinction of bacterial epidemics hospitals is attributed changes medical practice, including infection control, but role adaptation has never been documented. We analysed collection Pseudomonas aeruginosa isolates belonging Besançon Epidemic Strain (BES), responsible for 12year nosocomial outbreak, using genotype-to-phenotype approach. Bayesian analysis estimated emergence clone 5 years...
Pseudomonas aeruginosa is a human opportunistic pathogen responsible for nosocomial infections, which largely used as model organism to study antibiotic resistance and pathogenesis. As other species of the genus, its wide metabolic versatility appears be attractive biotechnological applications. However, natural antibiotics capacity produce range virulence factors argue against potential. By reducing genome reference strain PAO1, we explored development four hypovirulent hypersusceptible...
In this paper I pursue an avenue of argument implicit in Patristic thinkers — such as Tertullian and Athanasius explicit the thomistic scholastic tradition. argue that there is ontological unity to world, calls for explanation terms a transcendent cause, traditionally identified with God.
Abstract The biological features that allow a pathogen to survive in the hospital environment are mostly unknown. extinction of bacterial epidemics hospitals is attributed changes medical practice, including infection control, but role adaptation has never been documented. We analyzed collection Pseudomonas aeruginosa isolates belonging Besançon Epidemic Strain (BES), responsible for 12-year nosocomial outbreak, using genotype-to-phenotype approach. Bayesian analysis estimated emergence...