A5001142761- Liver Disease Diagnosis and Treatment
- Inflammatory Bowel Disease
- Gastrointestinal disorders and treatments
- Liver Disease and Transplantation
- Hepatitis B Virus Studies
- Gallbladder and Bile Duct Disorders
- Microscopic Colitis
- Blood Coagulation and Thrombosis Mechanisms
- Hepatitis C virus research
- Gastrointestinal Tumor Research and Treatment
- Gastric Cancer Management and Outcomes
- Pediatric Hepatobiliary Diseases and Treatments
- Autoimmune and Inflammatory Disorders
- Pancreatitis Pathology and Treatment
- Viral-associated cancers and disorders
- Potassium and Related Disorders
- Helicobacter pylori-related gastroenterology studies
- Colorectal Cancer Screening and Detection
- Esophageal and GI Pathology
- Hepatocellular Carcinoma Treatment and Prognosis
- Nutrition and Health in Aging
- Biliary and Gastrointestinal Fistulas
- Vasculitis and related conditions
- Kawasaki Disease and Coronary Complications
- Clinical Nutrition and Gastroenterology
Şişli Etfal Eğitim ve Araştırma Hastanesi
2013-2023
Sağlık Bilimleri Üniversitesi
2021-2023
Memorial Sisli Hospital
2021
Istanbul University
2015
Bakırköy Dr.Sadi Konuk Eğitim ve Araştırma Hastanesi
2010-2012
Türkiye Yüksek İhtisas Hastanesi
2001-2008
Gazi University
2007
This study was planned for searching possible changes of the total coagulation and fibrinolysis system in inflammatory bowel disease (IBD) order to obtain some clues explaining relation between IBD hypercoagulability. A 24 patients with ulcerative colitis, 12 Crohn disease, 20 healthy controls were studied. Platelets; prothrombin time (PT); partial thromboplastin (PTT); fibrinogen; D-dimer; fibrinogen degradation products; protein C; S; antithrombin; thrombin time; von Willebrand factor;...
ST2, a specific ligand of interleukin 33, was described as biomarker protein inflammatory processes and overexpression ST2 in ulcerative colitis (UC) shown previously. We aimed to investigate the potential relationship serum levels with clinical, endoscopic histopathological activity scores UC Crohn's disease (CD). Serum were determined 143 patients bowel (IBD) (83 60 CD), 50 healthy controls (HC), 32 irritable syndrome (IBS). elevated IBD (56.8 (41.9-87.2) pg/mL) compared HC IBS (30.7...
Mild iron overload is frequently reported in patients with nonalcoholic fatty liver disease (NAFLD). Hepcidin the master iron-regulatory peptide and hemojuvelin (HJV) key regulator of iron-dependent secretion hepcidin. The aims this study were to evaluate serum HJV hepcidin levels biopsy-proven NAFLD without hepatic overload, identify potential associations clinical characteristics enrolled.Serum measured 66 (n=12) (n=54) controls (n=35) by enzyme-linked immunosorbent assay. Hemojuvelin...
In order to investigate the relationship between hemostatic abnormalities and portal vein thrombosis (PVT) in hepatocellular carcinoma (HCC), platelets, prothrombin time (PT), activated partial thromboplastin (aPTT), thrombin time, fibrinogen, d-dimer, fibrinogen degradation products (FDPs), protein C, S, antithrombin, plasminogen, antiplasmin, coagulation factors (CFs) V, VII, VIII, IX, XI, XIII, von Willebrand factor (vWF), fragment 1 + 2 (PF 2), tissue-type plasminogen activator (tPA),...
Nonalcoholic fatty liver disease (NAFLD) includes a variety of histopathological findings ranging from simple steatosis to nonalcoholic steatohepatitis (NASH) which can only be differentiated by biopsy. There is yet no unique biomarker found discriminate NASH steatosis.We aimed investigate the relationship plasma pentraxin 3 (PTX3) and its main stimulant tumor necrosis factor alpha (TNF-α) with degree damage in NAFLD.Plasma PTX3 TNF-α levels were measured 70 patients histologically verified...
Angiogenesis is an important process in the pathogenesis of chronic inflammation. We aimed to study angiogeneic balance inflammatory bowel disease (IBD) by evaluating expression vascular endothelial growth factor (VEGF) and thrombospondin-1 (TSP-1) on colonic epithelial cells, together with inducible nitric oxide synthase (iNOS).Twenty-one ulcerative colitis (UC), 14 Crohn's (CD), 11 colorectal cancer patients, healthy controls biopsy samples were evaluated immunohistochemically.The...
BackgroundTerminal ileum endoscopy and biopsy are the diagnostic tools of diseases attacking ileum. However, abnormal histological findings can be found in endoscopically normal terminal ileum.ObjectiveThis study was performed to evaluate histopathological results biopsies from order determine pre-procedure clinical laboratory factors predicting results, if any.MethodsA total 297 patients who underwent colonoscopy had or a few aphthous ulcers together with completely colon mucosa were...
Cardiovascular disease (CVD) is the most frequent cause of death in nonalcoholic fatty liver (NAFLD). Insulin resistance, hepatic dysfunction, and chronic inflammation are factors interacting explaining increased CVD incidence NAFLD. We aimed to evaluate effects insulin resistance inflammatory biomarkers on asymmetric dimethylarginine (ADMA) levels, a predictor CVD. also investigated relationship between these markers histological findings patients with NAFLD.Plasma ADMA, high-sensitivity...
Liver biopsy is the best method for detecting fibrosis grade of liver in chronic hepatitis B. However, invasiveness complicates its routine use follow-up treatment. We planned to determine usage predicting noninvasive scores treatment patients with B treated entecavir or tenofovir. Two hundred twenty-eight were included study. Fibrosis was determined by Ishak score. The laboratory data at months 0, 12, and 24 during collected (aspartate aminotransferase alanine ratio [AAR], aspartate...
Objective Sarcopenia is one of the most significant contributors to morbidity in patients with chronic liver disease. Serum myokines are potential biomarkers for detecting early sarcopenia. We aimed investigate relationship between serum and cirrhosis-related mortality stages Methods In total, 262 50 healthy controls were enrolled this study, which was designed as a multicenter cross-sectional study. At beginning sarcopenia defined by computed tomography scans using third lumbar vertebra...
Abstract Lipomas of the gastrointestinal tract are uncommon tumors. Almost all lipomas submucosal or subserosal, and most asymptomatic, although they may cause abdominal pain, bowel obstruction, bleeding. The diagnosis lipoma is usually not made before surgery. We present a case colonic intussusception caused by that was located in muscular layer colon diagnosed preoperatively sonography. descending appeared edematous thick. There layering within lumen colon, mimicking target sign. At distal...
An increase in the prevalence of colorectal polyps and cancer is reported patients with acromegaly. This trial designed to determine whether there an polyps/cancer Turkish acromegaly patients. Sixty-six patients, who were under follow-up diagnosis underwent total colonoscopic examination, enrolled study. Sixty-five age- gender-matched nonspecific complaints selected as control. The mean age acromegalic was 51.5 ± 12.8 years whom 27 (40.9%) females. In 20 (30.3%) a 65 detected. Forty-seven...
It is known that ulcerative proctitis might show extension, but in practice, patients with are not considered as important regard to regular follow-up and treatment. The aim of this study was evaluate the extension colitis cases limited rectum compare them rectosigmoid left colonic for their features, risk factors influencing natural course disease.The involved 193 (62 rectal, 49 82 left-sided) patients.Fourteen percent showed at least one proximal segment 3.9±2.9 (range: 0.8-12) years....
Cystatin C is a genuine marker for detecting minor reductions in estimated glomerular filtration rate (e-GFR).We aimed to investigate the efficiency of cystatin levels predicting nephrotoxicity due antiviral therapy patients with chronic hepatitis B virus infection.Seventy-six naive and 44 controls were enrolled this prospective cohort study.Serum C, phosphate creatinine levels, urinary albumin/creatinine ratios all measured at baseline, 3rd, 12th, 24th months. Nephrotoxicity was determined...
Helicobacter pylori infection is the main cause of gastritis, gastroduodenal ulcer disease, MALT lymphoma, and adenocarcinoma stomach. The reported prevalence H. in adult population Turkey 67.6%-81.3%. A national meta-analysis showed that average eradication rate with proton pump inhibitor-based triple regimens had decreased from 84% 1997 to 55.3% 2004, suggesting a need evaluate alternative regimens.The study was prospective, single-center trial parallel group design. After selection...