A5036422039- Developmental Biology and Gene Regulation
- Wnt/β-catenin signaling in development and cancer
- Fibroblast Growth Factor Research
- RNA Research and Splicing
- Muscle Physiology and Disorders
- Genomics and Phylogenetic Studies
- Fungal and yeast genetics research
- Genomics and Chromatin Dynamics
- Cellular Mechanics and Interactions
- 3D Printing in Biomedical Research
- Connective tissue disorders research
Medical University of Vienna
2022
Research Institute of Molecular Pathology
2018-2022
Vienna Biocenter
2021-2022
European Molecular Biology Laboratory
2018
Vertebrates harbor recognizably orthologous gene complements but vary 100-fold in genome size. How chromosomal organization scales with expansion is unclear, and how acute changes regulation, as during axolotl limb regeneration, occur the context of a vast has remained riddle. Here, we describe chromosome-scale assembly giant, 32 Gb genome. Hi-C contact data revealed scaling properties interphase mitotic chromosome organization. Analysis yielded understanding evolution large, syntenic...
Article15 November 2018Open Access Transparent process Downregulation of basal myosin-II is required for cell shape changes and tissue invagination Daniel Krueger European Molecular Biology Laboratory, Heidelberg, GermanyCandidate Joint PhD degree from EMBL Heidelberg University, Faculty Biosciences Search more papers by this author Pietro Tardivo Germany IMP, Vienna, Austria Congtin Nguyen Northeastern Boston, MA, USA Stefano De Renzis Corresponding Author [email protected]...
Axolotls can regenerate lost limbs throughout their lives, while they continue to grow. This poses the question of how size and pattern a regenerating limb is matched widely varying animal size. Two interacting signaling molecules, SHH FGF8, are produced at opposite sides sustain tissue growth through pair oppositely-oriented gradients. As regrowing vary more than three-fold depending on animal, it unclear activities these mutually dependent morphogens maintained subsequently terminated...
The expression of fibroblast growth factors (Fgf) ligands in a specialized epithelial compartment, the Apical Ectodermal Ridge (AER), is conserved feature limb development across vertebrate species. In vertebrates, Fgf 4, 8, 9, and 17 are all expressed AER. An exception to this paradigm salamander (axolotl) developing regenerating limb, where key mesenchyme. mesenchymal Amex.Fgf8 axolotl has been suggested be critical for regeneration. To date, there little knowledge regarding what controls...
Abstract The expression of Fibroblast growth factors (Fgf) ligands in a specialized epithelial compartment, the Apical Ectodermal Ridge (AER), is conserved feature limb development across vertebrate species. In vertebrates, Fgf 4, 8, 9 , and 17 are all expressed AER. An exception to this paradigm salamander (axolotl) developing regenerating limb, where key mesenchyme. mesenchymal Amex. Fgf8 axolotl has been suggested be critical for regeneration. To date, there little knowledge regarding...